Immunogenicity of self-associated aggregates and chemically cross-linked conjugates of the 42 kDa Plasmodium falciparum merozoite surface protein-1.

Immunogenicity of self-associated aggregates and chemically cross-linked conjugates of the 42 kDa Plasmodium falciparum merozoite surface protein-1.

Self-associated protein aggregates or cross-linked protein conjugates are, in general, more immunogenic than oligomeric or monomeric forms. In particular, the immunogenicity in mice of a recombinant malaria transmission blocking vaccine candidate, the ookinete specific Plasmodium falciparum 25 kDa p...

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Main Authors: Feng Qian, Karine Reiter, Yanling Zhang, Richard L Shimp, Vu Nguyen, Joan A Aebig, Kelly M Rausch, Daming Zhu, Lynn Lambert, Gregory E D Mullen, Laura B Martin, Carole A Long, Louis H Miller, David L Narum
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036996&type=printable
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