True-bone-ceramics / type I collagen scaffolds for repairing osteochondral defect
Abstract In recent years, the incidence of cartilage defects has increased dramatically, and its etiology is complex and varied. Osteochondritis dissecans (OCD), as one of the main etiologies, damages both cartilage and bone tissues and can progress to severe osteoarthritis, which has been one of th...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2024-12-01
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| Series: | Journal of Materials Science: Materials in Medicine |
| Online Access: | https://doi.org/10.1007/s10856-024-06852-5 |
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| _version_ | 1841559870076092416 |
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| author | Yuhan Jiang Tenghai Li Yingyue Lou Bingzhang Liu Yilin Liu Tian Li Duo Zhang |
| author_facet | Yuhan Jiang Tenghai Li Yingyue Lou Bingzhang Liu Yilin Liu Tian Li Duo Zhang |
| author_sort | Yuhan Jiang |
| collection | DOAJ |
| description | Abstract In recent years, the incidence of cartilage defects has increased dramatically, and its etiology is complex and varied. Osteochondritis dissecans (OCD), as one of the main etiologies, damages both cartilage and bone tissues and can progress to severe osteoarthritis, which has been one of the difficult problems for clinicians. The vigorous development of material science and tissue engineering provides new ideas for the treatment of OCD, in which the selection of scaffold materials is particularly important. In this study, true-bone-ceramics (TBC), which has good mechanical strength and osteoconductivity, and type I collagen (COL1), which has excellent biocompatibility, were chosen as scaffold materials to co-construct the TBC/COL1 scaffold for osteochondral repair. In order to ensure the most appropriate collagen coating concentration, three experimental groups (1, 5, 12 mg/ml) were set up. Through the physicochemical property test, biocompatibility analysis and in vivo implantation experiments of composite scaffolds, 12 mg/ml TBC/COL1 scaffolds present the best repair effect among the three groups. Graphical Abstract |
| format | Article |
| id | doaj-art-2bb86669f34241c182afb09d0add0798 |
| institution | Kabale University |
| issn | 1573-4838 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Materials Science: Materials in Medicine |
| spelling | doaj-art-2bb86669f34241c182afb09d0add07982025-01-05T12:07:20ZengSpringerJournal of Materials Science: Materials in Medicine1573-48382024-12-0136111310.1007/s10856-024-06852-5True-bone-ceramics / type I collagen scaffolds for repairing osteochondral defectYuhan Jiang0Tenghai Li1Yingyue Lou2Bingzhang Liu3Yilin Liu4Tian Li5Duo Zhang6Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin UniversityDepartment of Plastic and Reconstructive Surgery, The First Hospital of Jilin UniversityDepartment of Rehabilitation, The Second Hospital of Jilin UniversityDepartment of Plastic and Reconstructive Surgery, The First Hospital of Jilin UniversityDepartment of Plastic and Reconstructive Surgery, The First Hospital of Jilin UniversityDepartment of Plastic and Reconstructive Surgery, The First Hospital of Jilin UniversityDepartment of Plastic and Reconstructive Surgery, The First Hospital of Jilin UniversityAbstract In recent years, the incidence of cartilage defects has increased dramatically, and its etiology is complex and varied. Osteochondritis dissecans (OCD), as one of the main etiologies, damages both cartilage and bone tissues and can progress to severe osteoarthritis, which has been one of the difficult problems for clinicians. The vigorous development of material science and tissue engineering provides new ideas for the treatment of OCD, in which the selection of scaffold materials is particularly important. In this study, true-bone-ceramics (TBC), which has good mechanical strength and osteoconductivity, and type I collagen (COL1), which has excellent biocompatibility, were chosen as scaffold materials to co-construct the TBC/COL1 scaffold for osteochondral repair. In order to ensure the most appropriate collagen coating concentration, three experimental groups (1, 5, 12 mg/ml) were set up. Through the physicochemical property test, biocompatibility analysis and in vivo implantation experiments of composite scaffolds, 12 mg/ml TBC/COL1 scaffolds present the best repair effect among the three groups. Graphical Abstracthttps://doi.org/10.1007/s10856-024-06852-5 |
| spellingShingle | Yuhan Jiang Tenghai Li Yingyue Lou Bingzhang Liu Yilin Liu Tian Li Duo Zhang True-bone-ceramics / type I collagen scaffolds for repairing osteochondral defect Journal of Materials Science: Materials in Medicine |
| title | True-bone-ceramics / type I collagen scaffolds for repairing osteochondral defect |
| title_full | True-bone-ceramics / type I collagen scaffolds for repairing osteochondral defect |
| title_fullStr | True-bone-ceramics / type I collagen scaffolds for repairing osteochondral defect |
| title_full_unstemmed | True-bone-ceramics / type I collagen scaffolds for repairing osteochondral defect |
| title_short | True-bone-ceramics / type I collagen scaffolds for repairing osteochondral defect |
| title_sort | true bone ceramics type i collagen scaffolds for repairing osteochondral defect |
| url | https://doi.org/10.1007/s10856-024-06852-5 |
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