Results of organ-preserving treatment of breast cancer using intraoperative radial therapy
Objective: to compare the immediate and long-term outcomes of patients with early breast cancer treated with intraoperative radial therapy depending on the biological subtype of breast cancer.Materials and methods. We prospectively evaluated number of recurrences, cosmetic effect and early treatment...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2021-10-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/859 |
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| author | I. S. Chumachenko R. A. Murashko A. A. Keshabyan P. V. Krivorotko S. N. Novikov |
| author_facet | I. S. Chumachenko R. A. Murashko A. A. Keshabyan P. V. Krivorotko S. N. Novikov |
| author_sort | I. S. Chumachenko |
| collection | DOAJ |
| description | Objective: to compare the immediate and long-term outcomes of patients with early breast cancer treated with intraoperative radial therapy depending on the biological subtype of breast cancer.Materials and methods. We prospectively evaluated number of recurrences, cosmetic effect and early treatment results of 104 patients with early breast cancer aged 66.72 ± 0.68 years old. The mean follow-up period was 36 months. The mean dose on the surface of applicator was 17.8 Gy, on the depth 0.5 cm – 8.8 Gy, on the depth 1.0 cm – 5 Gy. The mean time of radiation was 22.15 min ± 28.09 sec.Results. The local recurrence was in 3 patients. The first patient had triple negative breast cancer subtype, the second patient had luminal B HER2+, and the third one had luminal B HER2– subtype. Relapses occurred in 7, 14 and 20 months after the end of treatment respectively. The recurrence rate in patients with luminal B biological subtype was 10.71 %; in patients with triple negative subtype was 20 %. All recurrences were found in the area of the postoperative scar.Conclusion. The obtained results question the rationale for the use of the demonstrated method in patients with luminal B and triple negative molecular subtypes of tumors. |
| format | Article |
| id | doaj-art-2bb6b3be978b4b3f8450cb7aaccadbd7 |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2021-10-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-2bb6b3be978b4b3f8450cb7aaccadbd72025-08-20T03:37:53ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272021-10-01173162310.17650/1994-4098-2021-17-3-16-23694Results of organ-preserving treatment of breast cancer using intraoperative radial therapyI. S. Chumachenko0R. A. Murashko1A. A. Keshabyan2P. V. Krivorotko3S. N. Novikov4City Clinical Oncology Dispensary No. 1, Ministry of Health of Krasnodar regionCity Clinical Oncology Dispensary No. 1, Ministry of Health of Krasnodar regionCity Clinical Oncology Dispensary No. 1, Ministry of Health of Krasnodar regionN.N. Petrov National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Petrov National Medical Research Center of Oncology, Ministry of Health of RussiaObjective: to compare the immediate and long-term outcomes of patients with early breast cancer treated with intraoperative radial therapy depending on the biological subtype of breast cancer.Materials and methods. We prospectively evaluated number of recurrences, cosmetic effect and early treatment results of 104 patients with early breast cancer aged 66.72 ± 0.68 years old. The mean follow-up period was 36 months. The mean dose on the surface of applicator was 17.8 Gy, on the depth 0.5 cm – 8.8 Gy, on the depth 1.0 cm – 5 Gy. The mean time of radiation was 22.15 min ± 28.09 sec.Results. The local recurrence was in 3 patients. The first patient had triple negative breast cancer subtype, the second patient had luminal B HER2+, and the third one had luminal B HER2– subtype. Relapses occurred in 7, 14 and 20 months after the end of treatment respectively. The recurrence rate in patients with luminal B biological subtype was 10.71 %; in patients with triple negative subtype was 20 %. All recurrences were found in the area of the postoperative scar.Conclusion. The obtained results question the rationale for the use of the demonstrated method in patients with luminal B and triple negative molecular subtypes of tumors.https://ojrs.abvpress.ru/ojrs/article/view/859breast cancerintraoperative radial therapybiological subtype of breast cancerrecurrence |
| spellingShingle | I. S. Chumachenko R. A. Murashko A. A. Keshabyan P. V. Krivorotko S. N. Novikov Results of organ-preserving treatment of breast cancer using intraoperative radial therapy Опухоли женской репродуктивной системы breast cancer intraoperative radial therapy biological subtype of breast cancer recurrence |
| title | Results of organ-preserving treatment of breast cancer using intraoperative radial therapy |
| title_full | Results of organ-preserving treatment of breast cancer using intraoperative radial therapy |
| title_fullStr | Results of organ-preserving treatment of breast cancer using intraoperative radial therapy |
| title_full_unstemmed | Results of organ-preserving treatment of breast cancer using intraoperative radial therapy |
| title_short | Results of organ-preserving treatment of breast cancer using intraoperative radial therapy |
| title_sort | results of organ preserving treatment of breast cancer using intraoperative radial therapy |
| topic | breast cancer intraoperative radial therapy biological subtype of breast cancer recurrence |
| url | https://ojrs.abvpress.ru/ojrs/article/view/859 |
| work_keys_str_mv | AT ischumachenko resultsoforganpreservingtreatmentofbreastcancerusingintraoperativeradialtherapy AT ramurashko resultsoforganpreservingtreatmentofbreastcancerusingintraoperativeradialtherapy AT aakeshabyan resultsoforganpreservingtreatmentofbreastcancerusingintraoperativeradialtherapy AT pvkrivorotko resultsoforganpreservingtreatmentofbreastcancerusingintraoperativeradialtherapy AT snnovikov resultsoforganpreservingtreatmentofbreastcancerusingintraoperativeradialtherapy |