Association between the development of sepsis and the triglyceride-glucose index in acute pancreatitis patients: a retrospective investigation utilizing the MIMIC-IV database
Abstract Background Sepsis is a serious consequence of acute pancreatitis (AP) that requires immediate detection and treatment. Triglyceride-glucose (TyG) index demonstrated predictive ability for a number of diseases. In an effort to enhance clinical care and early warning systems, this study exami...
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2025-02-01
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| Online Access: | https://doi.org/10.1186/s12876-025-03663-y |
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| author | Lin Xu Xuejing Li Na Zhang Chunmei Guo Pan Wang Min Gao Yanhui Zhang Lixin Zhao |
| author_facet | Lin Xu Xuejing Li Na Zhang Chunmei Guo Pan Wang Min Gao Yanhui Zhang Lixin Zhao |
| author_sort | Lin Xu |
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| description | Abstract Background Sepsis is a serious consequence of acute pancreatitis (AP) that requires immediate detection and treatment. Triglyceride-glucose (TyG) index demonstrated predictive ability for a number of diseases. In an effort to enhance clinical care and early warning systems, this study examined the association between the TyG index and sepsis risk with the aim of improving clinical care and early warning systems. Methods Patients who were first admitted and satisfied the diagnostic criteria for acute pancreatitis (ICD-9: 5770; ICD-10: K85) were chosen from the MIMIC-IV database, excluding those lacking essential demographic or laboratory data. Using the Sepsis-3.0 criteria. Depending on whether they had sepsis or not, patients were divided into sepsis group and non-sepsis group. Utilizing the formula ln[(triglycerides mg/dl) × (glucose mg/dl)/2], the TyG index was calculated. The Boruta algorithm and Xgboost model were used for feature selection in order to pinpoint the important variables affecting results. Logistic regression with univariate and multivariate factors were used to assess the association between the TyG index and the start of sepsis after admission. Results Twenty-eight thousand AP patients were screened in all, among which 661 patients were ultimately included in the study. Of these, 228 patients (34.5%) developed sepsis. The TyG index was shown to have a significant correlation (OR = 1.891, 95% CI: 1.408–2.555) with sepsis, and an increased risk of sepsis was observed with an increase in the TyG index (all P values for trend < 0.001). Subgroup analysis showed that among patients of various ages, sexes, and with hypertension and diabetes, there was a positive association between the TyG index and the probability of sepsis (all P values for trend < 0.05). The combination of the TyG index with clinical indicators had an area under the curve (AUC) of 0.828 (0.794–0.862), which was significantly greater than that of the TyG index alone (0.657 [0.613–0.701]), with a statistically significant difference (Z= -7.362, P < 0.001). Conclusion In patients who have AP, the TyG index is substantially linked to a higher risk of sepsis, and when combined with clinical markers, its predictive power for sepsis is enhanced. The findings imply that the TyG index might be a helpful detection for determining which AP patients are at a higher risk of developing sepsis. |
| format | Article |
| id | doaj-art-2bb5258afd8c41e3a88a6d53648a98cd |
| institution | OA Journals |
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| publishDate | 2025-02-01 |
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| spelling | doaj-art-2bb5258afd8c41e3a88a6d53648a98cd2025-08-20T02:13:06ZengBMCBMC Gastroenterology1471-230X2025-02-0125111110.1186/s12876-025-03663-yAssociation between the development of sepsis and the triglyceride-glucose index in acute pancreatitis patients: a retrospective investigation utilizing the MIMIC-IV databaseLin Xu0Xuejing Li1Na Zhang2Chunmei Guo3Pan Wang4Min Gao5Yanhui Zhang6Lixin Zhao7Department of Emergency, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Emergency, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Emergency, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Emergency, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Emergency, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Emergency, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Emergency, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Emergency, Beijing Chao-Yang Hospital, Capital Medical UniversityAbstract Background Sepsis is a serious consequence of acute pancreatitis (AP) that requires immediate detection and treatment. Triglyceride-glucose (TyG) index demonstrated predictive ability for a number of diseases. In an effort to enhance clinical care and early warning systems, this study examined the association between the TyG index and sepsis risk with the aim of improving clinical care and early warning systems. Methods Patients who were first admitted and satisfied the diagnostic criteria for acute pancreatitis (ICD-9: 5770; ICD-10: K85) were chosen from the MIMIC-IV database, excluding those lacking essential demographic or laboratory data. Using the Sepsis-3.0 criteria. Depending on whether they had sepsis or not, patients were divided into sepsis group and non-sepsis group. Utilizing the formula ln[(triglycerides mg/dl) × (glucose mg/dl)/2], the TyG index was calculated. The Boruta algorithm and Xgboost model were used for feature selection in order to pinpoint the important variables affecting results. Logistic regression with univariate and multivariate factors were used to assess the association between the TyG index and the start of sepsis after admission. Results Twenty-eight thousand AP patients were screened in all, among which 661 patients were ultimately included in the study. Of these, 228 patients (34.5%) developed sepsis. The TyG index was shown to have a significant correlation (OR = 1.891, 95% CI: 1.408–2.555) with sepsis, and an increased risk of sepsis was observed with an increase in the TyG index (all P values for trend < 0.001). Subgroup analysis showed that among patients of various ages, sexes, and with hypertension and diabetes, there was a positive association between the TyG index and the probability of sepsis (all P values for trend < 0.05). The combination of the TyG index with clinical indicators had an area under the curve (AUC) of 0.828 (0.794–0.862), which was significantly greater than that of the TyG index alone (0.657 [0.613–0.701]), with a statistically significant difference (Z= -7.362, P < 0.001). Conclusion In patients who have AP, the TyG index is substantially linked to a higher risk of sepsis, and when combined with clinical markers, its predictive power for sepsis is enhanced. The findings imply that the TyG index might be a helpful detection for determining which AP patients are at a higher risk of developing sepsis.https://doi.org/10.1186/s12876-025-03663-yAcute pancreatitisSepsisTriglyceride-glucose indexMIMIC-IV database |
| spellingShingle | Lin Xu Xuejing Li Na Zhang Chunmei Guo Pan Wang Min Gao Yanhui Zhang Lixin Zhao Association between the development of sepsis and the triglyceride-glucose index in acute pancreatitis patients: a retrospective investigation utilizing the MIMIC-IV database BMC Gastroenterology Acute pancreatitis Sepsis Triglyceride-glucose index MIMIC-IV database |
| title | Association between the development of sepsis and the triglyceride-glucose index in acute pancreatitis patients: a retrospective investigation utilizing the MIMIC-IV database |
| title_full | Association between the development of sepsis and the triglyceride-glucose index in acute pancreatitis patients: a retrospective investigation utilizing the MIMIC-IV database |
| title_fullStr | Association between the development of sepsis and the triglyceride-glucose index in acute pancreatitis patients: a retrospective investigation utilizing the MIMIC-IV database |
| title_full_unstemmed | Association between the development of sepsis and the triglyceride-glucose index in acute pancreatitis patients: a retrospective investigation utilizing the MIMIC-IV database |
| title_short | Association between the development of sepsis and the triglyceride-glucose index in acute pancreatitis patients: a retrospective investigation utilizing the MIMIC-IV database |
| title_sort | association between the development of sepsis and the triglyceride glucose index in acute pancreatitis patients a retrospective investigation utilizing the mimic iv database |
| topic | Acute pancreatitis Sepsis Triglyceride-glucose index MIMIC-IV database |
| url | https://doi.org/10.1186/s12876-025-03663-y |
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