AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway

AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway

Abstract Obesity and diabetes are risk factors for hepatocellular carcinoma (HCC); however, the underlying mechanisms are yet to be elucidated. Adeno‐associated virus (AAV) frequently infects humans and has been widely used in gene therapy, but the risk of AAV infection such as HCC should be further...

Full description

Saved in:
Bibliographic Details
Main Authors: Yalan Cheng, Zhentong Zhang, Peidong Gao, Hejin Lai, Wuling Zhong, Ning Feng, Yale Yang, Huimin Yu, Yali Zhang, Yumo Han, Jieya Dong, Zhishui He, Rui Huang, Qiwei Zhai
Format: Article
Language:English
Published: Springer Nature 2023-06-01
Series:EMBO Molecular Medicine
Subjects:
diabetes
HCC
necroptosis
obesity
rAAV
Online Access:https://doi.org/10.15252/emmm.202217230
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items