CD4 Cell Counts at HIV Diagnosis among HIV Outpatient Study Participants, 2000–2009
Background. It is unclear if CD4 cell counts at HIV diagnosis have improved over a 10-year period of expanded HIV testing in the USA. Methods. We studied HOPS participants diagnosed with HIV infection ≤6 months prior to entry into care during 2000–2009. We assessed the correlates of CD4 count <20...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2012/869841 |
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| _version_ | 1832554208544423936 |
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| author | Kate Buchacz Carl Armon Frank J. Palella Rose K. Baker Ellen Tedaldi Marcus D. Durham John T. Brooks |
| author_facet | Kate Buchacz Carl Armon Frank J. Palella Rose K. Baker Ellen Tedaldi Marcus D. Durham John T. Brooks |
| author_sort | Kate Buchacz |
| collection | DOAJ |
| description | Background. It is unclear if CD4 cell counts at HIV diagnosis have improved over a 10-year period of expanded HIV testing in the USA. Methods. We studied HOPS participants diagnosed with HIV infection ≤6 months prior to entry into care during 2000–2009. We assessed the correlates of CD4 count <200 cells/mm3 at HIV diagnosis (late HIV diagnosis) by logistic regression. Results. Of 1,203 eligible patients, 936 (78%) had a CD4 count within 3 months after HIV diagnosis. Median CD4 count at HIV diagnosis was 299 cells/mm3 and did not significantly improve over time (P=0.13). Comparing periods 2000-2001 versus 2008-2009, respectively, 39% and 35% of patients had a late HIV diagnosis (P=0.34). Independent correlates of late HIV diagnosis were having an HIV risk other than being MSM, age ≥35 years at diagnosis, and being of nonwhite race/ethnicity. Conclusions. There is need for routine universal HIV testing to reduce the frequency of late HIV diagnosis and increase opportunity for patient- and potentially population-level benefits associated with early antiretroviral treatment. |
| format | Article |
| id | doaj-art-2bb17e026fd14390899a70efdef89461 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-2bb17e026fd14390899a70efdef894612025-02-03T05:52:00ZengWileyAIDS Research and Treatment2090-12402090-12592012-01-01201210.1155/2012/869841869841CD4 Cell Counts at HIV Diagnosis among HIV Outpatient Study Participants, 2000–2009Kate Buchacz0Carl Armon1Frank J. Palella2Rose K. Baker3Ellen Tedaldi4Marcus D. Durham5John T. Brooks6Centers for Disease Control and Prevention, Atlanta, GA 30333, USACerner Corporation, Vienna, VA, USANorthwestern University, Chicago, IL, USACerner Corporation, Vienna, VA, USATemple University, Philadelphia, PA, USACenters for Disease Control and Prevention, Atlanta, GA 30333, USACenters for Disease Control and Prevention, Atlanta, GA 30333, USABackground. It is unclear if CD4 cell counts at HIV diagnosis have improved over a 10-year period of expanded HIV testing in the USA. Methods. We studied HOPS participants diagnosed with HIV infection ≤6 months prior to entry into care during 2000–2009. We assessed the correlates of CD4 count <200 cells/mm3 at HIV diagnosis (late HIV diagnosis) by logistic regression. Results. Of 1,203 eligible patients, 936 (78%) had a CD4 count within 3 months after HIV diagnosis. Median CD4 count at HIV diagnosis was 299 cells/mm3 and did not significantly improve over time (P=0.13). Comparing periods 2000-2001 versus 2008-2009, respectively, 39% and 35% of patients had a late HIV diagnosis (P=0.34). Independent correlates of late HIV diagnosis were having an HIV risk other than being MSM, age ≥35 years at diagnosis, and being of nonwhite race/ethnicity. Conclusions. There is need for routine universal HIV testing to reduce the frequency of late HIV diagnosis and increase opportunity for patient- and potentially population-level benefits associated with early antiretroviral treatment.http://dx.doi.org/10.1155/2012/869841 |
| spellingShingle | Kate Buchacz Carl Armon Frank J. Palella Rose K. Baker Ellen Tedaldi Marcus D. Durham John T. Brooks CD4 Cell Counts at HIV Diagnosis among HIV Outpatient Study Participants, 2000–2009 AIDS Research and Treatment |
| title | CD4 Cell Counts at HIV Diagnosis among HIV Outpatient Study Participants, 2000–2009 |
| title_full | CD4 Cell Counts at HIV Diagnosis among HIV Outpatient Study Participants, 2000–2009 |
| title_fullStr | CD4 Cell Counts at HIV Diagnosis among HIV Outpatient Study Participants, 2000–2009 |
| title_full_unstemmed | CD4 Cell Counts at HIV Diagnosis among HIV Outpatient Study Participants, 2000–2009 |
| title_short | CD4 Cell Counts at HIV Diagnosis among HIV Outpatient Study Participants, 2000–2009 |
| title_sort | cd4 cell counts at hiv diagnosis among hiv outpatient study participants 2000 2009 |
| url | http://dx.doi.org/10.1155/2012/869841 |
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