Transcriptomic and proteomic characterization of cell and protein biomarkers of checkpoint inhibitor-induced liver injury

Transcriptomic and proteomic characterization of cell and protein biomarkers of checkpoint inhibitor-induced liver injury

Abstract Immune checkpoint inhibitors (ICI) targeting CTLA-4 and PD-1 have shown remarkable antitumor efficacy, but can also cause immune-related adverse events, including checkpoint inhibitor-induced liver injury (ChILI). This multi-omic study aimed to investigate changes in blood samples from trea...

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Bibliographic Details
Main Authors: Changhua Ji, Steven Kumpf, Jessie Qian, Joel D. Federspiel, Mark Sheehan, Darien Capunitan, Edmond Atallah, Stuart Astbury, Seda Arat, Elias Oziolor, Mireia Fernandez Ocana, Shashi K. Ramaiah, Jane Grove, Guruprasad P. Aithal, Thomas A. Lanz
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Checkpoint inhibitor
ChILI
Liver injury
Biomarker
PD-L1
Online Access:https://doi.org/10.1007/s00262-025-04033-z
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