20-HETE mediates Ang II-induced cardiac hypertrophy via ROS and Ca2+ signaling in H9c2 cells

20-HETE mediates Ang II-induced cardiac hypertrophy via ROS and Ca2+ signaling in H9c2 cells

Abstract In the vascular system, angiotensin II (Ang II) mediated vasoconstriction by inducing the production of 20-hydroxyeicosatetraenoic acid (20-HETE). However, the role of 20-HETE in Ang II-induced cardiac dysfunction had yet to be fully elucidated. This study investigated the effects of Ang II...

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Bibliographic Details
Main Authors: Jingyi Han, Jiaojiao Li, Lianlian Liu, Kaiyuan Li, Chun Zhang, Yong Han
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
20-Hydroxyeicosatetraenoic acid
Angiotensin II
G protein-coupled receptor 75
Cardiac hypertrophy
Reactive oxygen species
Online Access:https://doi.org/10.1038/s41598-025-85992-2
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