Determining the most effective osteoporosis drug for bone mineral density loss in proximal area after total hip arthroplasty: A network meta-analysis
Purpose: The aim of this study was to compare and rank the efficacy of different drugs for bone mineral density (BMD) loss prevention at 1 year after total hip arthroplasty (THA) using a network meta-analysis (NMA) of randomized controlled trials (RCTs). Methods: A literature search was conducted ba...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Journal of Joint Surgery and Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S294970512400029X |
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| author | Akira Morita Emi Kamono Tadashi Oyama Hyonmin Choe Yutaka Inaba Naomi Kobayashi |
| author_facet | Akira Morita Emi Kamono Tadashi Oyama Hyonmin Choe Yutaka Inaba Naomi Kobayashi |
| author_sort | Akira Morita |
| collection | DOAJ |
| description | Purpose: The aim of this study was to compare and rank the efficacy of different drugs for bone mineral density (BMD) loss prevention at 1 year after total hip arthroplasty (THA) using a network meta-analysis (NMA) of randomized controlled trials (RCTs). Methods: A literature search was conducted based on the PRISMA statement. The searched databases included MEDLINE (through PubMed), Cochrane Central Register of Controlled Trials, and Cumulative Index to Nursing & Allied Health Literature (CINAHL). Only RCTs exploring the efficacy of currently available osteoporosis drugs in preventing periprosthetic BMD loss were included. A multivariate random-effects NMA was conducted to combine direct and indirect comparisons of agents using a frequentist consistency model. Regarding the efficacy rank, the frequentist analog to the surface under the cumulative ranking (SUCRA) probabilities, called the P-score, was used. Result: In total, 17 RCTs were extracted. According to the pairwise mean difference (95% confidence interval) in BMD change, the efficacy of teriparatide was highest in both zones 1 and 7. From the predicted treatment rankings for BMD changes, teriparatide was ranked as the best intervention in zone 1 (P-score = 0.8844) and zone 7 (P-score = 0.9044) Conclusions: The results suggest that teriparatide, zoledronic acid, alendronate, and etidronate may be options for the prevention of periprosthetic BMD loss in zones 1 and 7 at 1 year after THA. |
| format | Article |
| id | doaj-art-2ba3810bc9fd45289ac36cba6ca27003 |
| institution | DOAJ |
| issn | 2949-7051 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Joint Surgery and Research |
| spelling | doaj-art-2ba3810bc9fd45289ac36cba6ca270032025-08-20T03:06:00ZengElsevierJournal of Joint Surgery and Research2949-70512025-03-013181610.1016/j.jjoisr.2024.11.001Determining the most effective osteoporosis drug for bone mineral density loss in proximal area after total hip arthroplasty: A network meta-analysisAkira Morita0Emi Kamono1Tadashi Oyama2Hyonmin Choe3Yutaka Inaba4Naomi Kobayashi5Department of Orthopaedic Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Orthopaedic Surgery, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama 232-0024, JapanDepartment of Orthopaedic Surgery, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama 232-0024, JapanDepartment of Orthopaedic Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Orthopaedic Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Orthopaedic Surgery, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama 232-0024, Japan; Corresponding author. Department of Orthopaedic Surgery, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama 232-0024, Japan.Purpose: The aim of this study was to compare and rank the efficacy of different drugs for bone mineral density (BMD) loss prevention at 1 year after total hip arthroplasty (THA) using a network meta-analysis (NMA) of randomized controlled trials (RCTs). Methods: A literature search was conducted based on the PRISMA statement. The searched databases included MEDLINE (through PubMed), Cochrane Central Register of Controlled Trials, and Cumulative Index to Nursing & Allied Health Literature (CINAHL). Only RCTs exploring the efficacy of currently available osteoporosis drugs in preventing periprosthetic BMD loss were included. A multivariate random-effects NMA was conducted to combine direct and indirect comparisons of agents using a frequentist consistency model. Regarding the efficacy rank, the frequentist analog to the surface under the cumulative ranking (SUCRA) probabilities, called the P-score, was used. Result: In total, 17 RCTs were extracted. According to the pairwise mean difference (95% confidence interval) in BMD change, the efficacy of teriparatide was highest in both zones 1 and 7. From the predicted treatment rankings for BMD changes, teriparatide was ranked as the best intervention in zone 1 (P-score = 0.8844) and zone 7 (P-score = 0.9044) Conclusions: The results suggest that teriparatide, zoledronic acid, alendronate, and etidronate may be options for the prevention of periprosthetic BMD loss in zones 1 and 7 at 1 year after THA.http://www.sciencedirect.com/science/article/pii/S294970512400029XNetwork meta-analysisTotal hip arthroplastyBone mineral densityTeriparatideBisphosphonate |
| spellingShingle | Akira Morita Emi Kamono Tadashi Oyama Hyonmin Choe Yutaka Inaba Naomi Kobayashi Determining the most effective osteoporosis drug for bone mineral density loss in proximal area after total hip arthroplasty: A network meta-analysis Journal of Joint Surgery and Research Network meta-analysis Total hip arthroplasty Bone mineral density Teriparatide Bisphosphonate |
| title | Determining the most effective osteoporosis drug for bone mineral density loss in proximal area after total hip arthroplasty: A network meta-analysis |
| title_full | Determining the most effective osteoporosis drug for bone mineral density loss in proximal area after total hip arthroplasty: A network meta-analysis |
| title_fullStr | Determining the most effective osteoporosis drug for bone mineral density loss in proximal area after total hip arthroplasty: A network meta-analysis |
| title_full_unstemmed | Determining the most effective osteoporosis drug for bone mineral density loss in proximal area after total hip arthroplasty: A network meta-analysis |
| title_short | Determining the most effective osteoporosis drug for bone mineral density loss in proximal area after total hip arthroplasty: A network meta-analysis |
| title_sort | determining the most effective osteoporosis drug for bone mineral density loss in proximal area after total hip arthroplasty a network meta analysis |
| topic | Network meta-analysis Total hip arthroplasty Bone mineral density Teriparatide Bisphosphonate |
| url | http://www.sciencedirect.com/science/article/pii/S294970512400029X |
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