Psoriasis and Seborrheic Keratoses: Insights from Biologic Therapy and Skin Imaging
Psoriasis is one of the most frequent immune-mediated chronic inflammatory cutaneous disease that exerts a considerable psychological impact, including low self-esteem, stigmatization, and depression. In recent years, biologic therapies have substantially transformed the therapeutic landscape for in...
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MDPI AG
2025-03-01
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| Online Access: | https://www.mdpi.com/2075-1729/15/3/485 |
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| author | Florin Ciprian Bujoreanu Diana Sabina Radaschin Mihail Alexandru Badea Laura Bujoreanu Bezman Carmen Pantiș Carmen Tiutiuca Liliana Baroiu Elena Niculeț Alina Pleșea Condratovici Alin Laurențiu Tatu |
| author_facet | Florin Ciprian Bujoreanu Diana Sabina Radaschin Mihail Alexandru Badea Laura Bujoreanu Bezman Carmen Pantiș Carmen Tiutiuca Liliana Baroiu Elena Niculeț Alina Pleșea Condratovici Alin Laurențiu Tatu |
| author_sort | Florin Ciprian Bujoreanu |
| collection | DOAJ |
| description | Psoriasis is one of the most frequent immune-mediated chronic inflammatory cutaneous disease that exerts a considerable psychological impact, including low self-esteem, stigmatization, and depression. In recent years, biologic therapies have substantially transformed the therapeutic landscape for individuals with moderate-to-severe psoriasis, shifting treatment towards a more targeted and personalized approach. Seborrheic keratoses (SKs) are common benign skin lesions, and their association with psoriasis and biologic therapy remains poorly understood. Our retrospective study evaluated a small cohort of patients with moderate-to-severe psoriasis undergoing biologic therapy at a tertiary dermatology center in Southeastern Europe to evaluate potential correlations with SK development. Smokers had fewer SKs, whereas postmenopausal women and osteoporosis patients had significantly higher SK counts, implicating hormonal influences. PUVA therapy was linked to an increased SK count, whereas UVB and methotrexate treatments had a lesser effect. These findings suggest that biologic therapy and systemic factors may influence SK development, emphasizing the need for further prospective research. |
| format | Article |
| id | doaj-art-2ba2c38b9a5a48878c5a5cfe5b5dbe68 |
| institution | OA Journals |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-2ba2c38b9a5a48878c5a5cfe5b5dbe682025-08-20T02:11:21ZengMDPI AGLife2075-17292025-03-0115348510.3390/life15030485Psoriasis and Seborrheic Keratoses: Insights from Biologic Therapy and Skin ImagingFlorin Ciprian Bujoreanu0Diana Sabina Radaschin1Mihail Alexandru Badea2Laura Bujoreanu Bezman3Carmen Pantiș4Carmen Tiutiuca5Liliana Baroiu6Elena Niculeț7Alina Pleșea Condratovici8Alin Laurențiu Tatu9Department of Dermatology, “Saint Parascheva” Infectious Disease Clinical Hospital, 800179 Galati, RomaniaDepartment of Dermatology, “Saint Parascheva” Infectious Disease Clinical Hospital, 800179 Galati, RomaniaDepartment of Dermatology, University of Medicine, Pharmacy, Science and Technology “George Emil Palade” of Targu Mures, 540142 Targu Mures, RomaniaFaculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, 800385 Galati, RomaniaDepartment of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 1 University Street, 410087 Oradea, RomaniaFaculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, 800385 Galati, RomaniaFaculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, 800385 Galati, RomaniaFaculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, 800385 Galati, RomaniaFaculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, 800385 Galati, RomaniaDepartment of Dermatology, “Saint Parascheva” Infectious Disease Clinical Hospital, 800179 Galati, RomaniaPsoriasis is one of the most frequent immune-mediated chronic inflammatory cutaneous disease that exerts a considerable psychological impact, including low self-esteem, stigmatization, and depression. In recent years, biologic therapies have substantially transformed the therapeutic landscape for individuals with moderate-to-severe psoriasis, shifting treatment towards a more targeted and personalized approach. Seborrheic keratoses (SKs) are common benign skin lesions, and their association with psoriasis and biologic therapy remains poorly understood. Our retrospective study evaluated a small cohort of patients with moderate-to-severe psoriasis undergoing biologic therapy at a tertiary dermatology center in Southeastern Europe to evaluate potential correlations with SK development. Smokers had fewer SKs, whereas postmenopausal women and osteoporosis patients had significantly higher SK counts, implicating hormonal influences. PUVA therapy was linked to an increased SK count, whereas UVB and methotrexate treatments had a lesser effect. These findings suggest that biologic therapy and systemic factors may influence SK development, emphasizing the need for further prospective research.https://www.mdpi.com/2075-1729/15/3/485psoriasisbiological therapiesseborrheic keratosesreflectance confocal microscopydermoscopyskin cancer |
| spellingShingle | Florin Ciprian Bujoreanu Diana Sabina Radaschin Mihail Alexandru Badea Laura Bujoreanu Bezman Carmen Pantiș Carmen Tiutiuca Liliana Baroiu Elena Niculeț Alina Pleșea Condratovici Alin Laurențiu Tatu Psoriasis and Seborrheic Keratoses: Insights from Biologic Therapy and Skin Imaging Life psoriasis biological therapies seborrheic keratoses reflectance confocal microscopy dermoscopy skin cancer |
| title | Psoriasis and Seborrheic Keratoses: Insights from Biologic Therapy and Skin Imaging |
| title_full | Psoriasis and Seborrheic Keratoses: Insights from Biologic Therapy and Skin Imaging |
| title_fullStr | Psoriasis and Seborrheic Keratoses: Insights from Biologic Therapy and Skin Imaging |
| title_full_unstemmed | Psoriasis and Seborrheic Keratoses: Insights from Biologic Therapy and Skin Imaging |
| title_short | Psoriasis and Seborrheic Keratoses: Insights from Biologic Therapy and Skin Imaging |
| title_sort | psoriasis and seborrheic keratoses insights from biologic therapy and skin imaging |
| topic | psoriasis biological therapies seborrheic keratoses reflectance confocal microscopy dermoscopy skin cancer |
| url | https://www.mdpi.com/2075-1729/15/3/485 |
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