Synthesis, anticancer evaluation, and electrochemical investigation of new chiral pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides

Synthesis, anticancer evaluation, and electrochemical investigation of new chiral pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides

Abstract Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides (MM-compounds) represent a novel class of heterocyclic compounds with promising anticancer potential. In this study, we report the synthesis and biological evaluation of two enantiomeric derivatives: the R-enantiomer (MM124) and th...

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Bibliographic Details
Main Authors: Mateusz Kciuk, Gabriela Machura, Somdutt Mujwar, Beata Marciniak, Kamila Koszelska, Sylwia Smarzewska, Mariusz Mojzych, Renata Kontek
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Cancer
Drug
Pyrazole
Tetrazole
Triazine
Online Access:https://doi.org/10.1038/s41598-025-02835-w
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