Towards precise synthetic neural codes: high-dimensional stimulation with flexible electrodes
Abstract Neural representations arise from high-dimensional population activity, but current neuromodulation methods lack the precision to write information into the central nervous system at this complexity. In this perspective, we propose high-dimensional stimulation as an approach to better appro...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | npj Flexible Electronics |
| Online Access: | https://doi.org/10.1038/s41528-025-00447-y |
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| _version_ | 1849235673829081088 |
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| author | Robin Kim Yuxuan Liu Jiaao Zhang Chong Xie Lan Luan |
| author_facet | Robin Kim Yuxuan Liu Jiaao Zhang Chong Xie Lan Luan |
| author_sort | Robin Kim |
| collection | DOAJ |
| description | Abstract Neural representations arise from high-dimensional population activity, but current neuromodulation methods lack the precision to write information into the central nervous system at this complexity. In this perspective, we propose high-dimensional stimulation as an approach to better approximate natural neural codes for brain-machine interfaces. Key advancements in resolution, coverage, and safety are essential, with flexible microelectrode arrays offering a promising path toward precise synthetic neural codes. |
| format | Article |
| id | doaj-art-2b9bcd3621db4dd48bcb9c0f6381b31f |
| institution | Kabale University |
| issn | 2397-4621 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Flexible Electronics |
| spelling | doaj-art-2b9bcd3621db4dd48bcb9c0f6381b31f2025-08-20T04:02:42ZengNature Portfolionpj Flexible Electronics2397-46212025-07-019111110.1038/s41528-025-00447-yTowards precise synthetic neural codes: high-dimensional stimulation with flexible electrodesRobin Kim0Yuxuan Liu1Jiaao Zhang2Chong Xie3Lan Luan4Department of Electrical and Computer Engineering, Rice UniversityRice Neuroengineering Initiative, Rice UniversityDepartment of Electrical and Computer Engineering, Rice UniversityDepartment of Electrical and Computer Engineering, Rice UniversityDepartment of Electrical and Computer Engineering, Rice UniversityAbstract Neural representations arise from high-dimensional population activity, but current neuromodulation methods lack the precision to write information into the central nervous system at this complexity. In this perspective, we propose high-dimensional stimulation as an approach to better approximate natural neural codes for brain-machine interfaces. Key advancements in resolution, coverage, and safety are essential, with flexible microelectrode arrays offering a promising path toward precise synthetic neural codes.https://doi.org/10.1038/s41528-025-00447-y |
| spellingShingle | Robin Kim Yuxuan Liu Jiaao Zhang Chong Xie Lan Luan Towards precise synthetic neural codes: high-dimensional stimulation with flexible electrodes npj Flexible Electronics |
| title | Towards precise synthetic neural codes: high-dimensional stimulation with flexible electrodes |
| title_full | Towards precise synthetic neural codes: high-dimensional stimulation with flexible electrodes |
| title_fullStr | Towards precise synthetic neural codes: high-dimensional stimulation with flexible electrodes |
| title_full_unstemmed | Towards precise synthetic neural codes: high-dimensional stimulation with flexible electrodes |
| title_short | Towards precise synthetic neural codes: high-dimensional stimulation with flexible electrodes |
| title_sort | towards precise synthetic neural codes high dimensional stimulation with flexible electrodes |
| url | https://doi.org/10.1038/s41528-025-00447-y |
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