Germ cell depletion using HSV-TK in mouse testes

Germ cell depletion using HSV-TK in mouse testes

Abstract Germ cell transplantation is useful for the study of male germ cells and the generation of genetically modified animals. For transplantation, germ cell-free hosts generated using anticancer drug treatment, irradiation exposure, or genetic mutation are required. In this study, we aimed to de...

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Bibliographic Details
Main Authors: Constance Dollet, Miyuki Shindo, Shun Takahashi, Kento Ito, Tomoo Eto, Toshiaki Watanabe
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Germ cell transplantation
Spermatogonial stem cells
Host mice
Testes
HSV-TK
DDX4
Online Access:https://doi.org/10.1038/s41598-025-93325-6
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