[F]PSMA-1007 PET/MR as a Precision Biomarker for Early Detection of Biochemical Recurrence in Prostate Cancer at Very Low PSA Levels
Background: Prostate cancer (PCa) patients with biochemical recurrence (BCR) following radical prostatectomy or radiation therapy often present with very low prostate-specific antigen (PSA) levels (⩽0.5 ng/mL). Accurate detection of recurrence at such low levels is crucial for guiding treatment deci...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-03-01
|
| Series: | Biomarker Insights |
| Online Access: | https://doi.org/10.1177/11772719251324307 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850222633023438848 |
|---|---|
| author | Ko-Han Lin Tzu-Chun Wei Shu-Huei Shen William Ji-Shien Huang Mei-Hua Chuang Nan-Jing Peng Wen-Tao Huang Yuh-Feng Wang |
| author_facet | Ko-Han Lin Tzu-Chun Wei Shu-Huei Shen William Ji-Shien Huang Mei-Hua Chuang Nan-Jing Peng Wen-Tao Huang Yuh-Feng Wang |
| author_sort | Ko-Han Lin |
| collection | DOAJ |
| description | Background: Prostate cancer (PCa) patients with biochemical recurrence (BCR) following radical prostatectomy or radiation therapy often present with very low prostate-specific antigen (PSA) levels (⩽0.5 ng/mL). Accurate detection of recurrence at such low levels is crucial for guiding treatment decisions. Objectives: To assess the diagnostic efficacy of [ 18 F]PSMA-1007 PET/MR (PSMA-PETMR) in detecting BCR of PCa in patients with very low PSA levels. Design: A prospective study conducted between May 2021 and January 2023, with data subsequently analyzed retrospectively after a 2-year follow-up. Methods: The cohort comprised 157 PCa patients with BCR, of whom 52 had PSA levels ⩽ 0.5 ng/mL and underwent PSMA-PETMR imaging. The imaging protocol incorporated multiparametric MRI (mpMRI) and PET acquisitions, with lesion classification following PSMA-RADS version 1.0. Detection rates of recurrent lesions, including local recurrence, lymph node metastasis, and skeletal metastasis, were evaluated. Results: PSMA-PETMR exhibited a 63.5% detection rate for recurrent PCa at low PSA levels, surpassing traditional diagnostic methods. Thirty-four local recurrences, 12 metastatic lymph nodes, and 4 skeletal metastases were identified. Follow-up imaging enhanced the detection rate to 73.1% by reclassifying initially equivocal findings. PSMA-PETMR influenced clinical decision-making in 17% of patients by facilitating personalized treatment strategies. Conclusion: PSMA-PETMR significantly improves the detection of recurrent PCa in patients with very low PSA levels, offering precise lesion localization and supporting personalized treatment approaches. Further studies are needed to optimize its clinical use and validate its long-term benefits. |
| format | Article |
| id | doaj-art-2b8ca94ce88842e1bf780a26d55765fb |
| institution | OA Journals |
| issn | 1177-2719 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Biomarker Insights |
| spelling | doaj-art-2b8ca94ce88842e1bf780a26d55765fb2025-08-20T02:06:16ZengSAGE PublishingBiomarker Insights1177-27192025-03-012010.1177/11772719251324307[F]PSMA-1007 PET/MR as a Precision Biomarker for Early Detection of Biochemical Recurrence in Prostate Cancer at Very Low PSA LevelsKo-Han Lin0Tzu-Chun Wei1Shu-Huei Shen2William Ji-Shien Huang3Mei-Hua Chuang4Nan-Jing Peng5Wen-Tao Huang6Yuh-Feng Wang7Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Urology, College of Medicine and Shu-Tien Urological Research Center, National Yang Ming Chiao Tung University, Taipei, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Urology, College of Medicine and Shu-Tien Urological Research Center, National Yang Ming Chiao Tung University, Taipei, TaiwanMacKay Junior College of Medicine, Nursing, and Management, New Taipei, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Medical Imaging and Radiological Technology, Yuanpei University of Medical Technology, Hsinchu, TaiwanDepartment of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei, TaiwanBackground: Prostate cancer (PCa) patients with biochemical recurrence (BCR) following radical prostatectomy or radiation therapy often present with very low prostate-specific antigen (PSA) levels (⩽0.5 ng/mL). Accurate detection of recurrence at such low levels is crucial for guiding treatment decisions. Objectives: To assess the diagnostic efficacy of [ 18 F]PSMA-1007 PET/MR (PSMA-PETMR) in detecting BCR of PCa in patients with very low PSA levels. Design: A prospective study conducted between May 2021 and January 2023, with data subsequently analyzed retrospectively after a 2-year follow-up. Methods: The cohort comprised 157 PCa patients with BCR, of whom 52 had PSA levels ⩽ 0.5 ng/mL and underwent PSMA-PETMR imaging. The imaging protocol incorporated multiparametric MRI (mpMRI) and PET acquisitions, with lesion classification following PSMA-RADS version 1.0. Detection rates of recurrent lesions, including local recurrence, lymph node metastasis, and skeletal metastasis, were evaluated. Results: PSMA-PETMR exhibited a 63.5% detection rate for recurrent PCa at low PSA levels, surpassing traditional diagnostic methods. Thirty-four local recurrences, 12 metastatic lymph nodes, and 4 skeletal metastases were identified. Follow-up imaging enhanced the detection rate to 73.1% by reclassifying initially equivocal findings. PSMA-PETMR influenced clinical decision-making in 17% of patients by facilitating personalized treatment strategies. Conclusion: PSMA-PETMR significantly improves the detection of recurrent PCa in patients with very low PSA levels, offering precise lesion localization and supporting personalized treatment approaches. Further studies are needed to optimize its clinical use and validate its long-term benefits.https://doi.org/10.1177/11772719251324307 |
| spellingShingle | Ko-Han Lin Tzu-Chun Wei Shu-Huei Shen William Ji-Shien Huang Mei-Hua Chuang Nan-Jing Peng Wen-Tao Huang Yuh-Feng Wang [F]PSMA-1007 PET/MR as a Precision Biomarker for Early Detection of Biochemical Recurrence in Prostate Cancer at Very Low PSA Levels Biomarker Insights |
| title | [F]PSMA-1007 PET/MR as a Precision Biomarker for Early Detection of Biochemical Recurrence in Prostate Cancer at Very Low PSA Levels |
| title_full | [F]PSMA-1007 PET/MR as a Precision Biomarker for Early Detection of Biochemical Recurrence in Prostate Cancer at Very Low PSA Levels |
| title_fullStr | [F]PSMA-1007 PET/MR as a Precision Biomarker for Early Detection of Biochemical Recurrence in Prostate Cancer at Very Low PSA Levels |
| title_full_unstemmed | [F]PSMA-1007 PET/MR as a Precision Biomarker for Early Detection of Biochemical Recurrence in Prostate Cancer at Very Low PSA Levels |
| title_short | [F]PSMA-1007 PET/MR as a Precision Biomarker for Early Detection of Biochemical Recurrence in Prostate Cancer at Very Low PSA Levels |
| title_sort | f psma 1007 pet mr as a precision biomarker for early detection of biochemical recurrence in prostate cancer at very low psa levels |
| url | https://doi.org/10.1177/11772719251324307 |
| work_keys_str_mv | AT kohanlin fpsma1007petmrasaprecisionbiomarkerforearlydetectionofbiochemicalrecurrenceinprostatecanceratverylowpsalevels AT tzuchunwei fpsma1007petmrasaprecisionbiomarkerforearlydetectionofbiochemicalrecurrenceinprostatecanceratverylowpsalevels AT shuhueishen fpsma1007petmrasaprecisionbiomarkerforearlydetectionofbiochemicalrecurrenceinprostatecanceratverylowpsalevels AT williamjishienhuang fpsma1007petmrasaprecisionbiomarkerforearlydetectionofbiochemicalrecurrenceinprostatecanceratverylowpsalevels AT meihuachuang fpsma1007petmrasaprecisionbiomarkerforearlydetectionofbiochemicalrecurrenceinprostatecanceratverylowpsalevels AT nanjingpeng fpsma1007petmrasaprecisionbiomarkerforearlydetectionofbiochemicalrecurrenceinprostatecanceratverylowpsalevels AT wentaohuang fpsma1007petmrasaprecisionbiomarkerforearlydetectionofbiochemicalrecurrenceinprostatecanceratverylowpsalevels AT yuhfengwang fpsma1007petmrasaprecisionbiomarkerforearlydetectionofbiochemicalrecurrenceinprostatecanceratverylowpsalevels |