DDIT4 participates in high glucose-induced fibroblast-like synoviocytes overactivation and cartilage injury by regulating glycolysis

DDIT4 participates in high glucose-induced fibroblast-like synoviocytes overactivation and cartilage injury by regulating glycolysis

Objective: More and more evidence show that diabetes is closely related to osteoarthritis (OA). However, the role and mechanism of DNA damage-inducible transcript 4 protein (DDIT4) in diabetic OA (DOA) have not been clarified. Methods: We collected OA patients and non-OA subjects who underwent total...

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Bibliographic Details
Main Authors: Shuo Qiang, Cheng Cheng, Yonghui Dong, Chao Tang, Jia Zheng, Yunke Liu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Regenerative Therapy
Subjects:
DDIT4
Diabetic osteoarthritis
Fibroblast-like synoviocytes
Cartilage injury
Glycolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320425000537
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