Alkaline Phosphatase and Disaccharide Activity in Barrett's Columnar Lined Esophagus
Esophageal mucosal biopsies of 15 patients with normal squamous epithelium, 11 with inflamed squamous epithelium and 23 with Barrete's columnar lined esophagus were assayed for alkaline phosphatase and disaccharidase activity. Seven of the patients with Barrett's esophagus had alkaline pho...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1988-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1988/584697 |
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| Summary: | Esophageal mucosal biopsies of 15 patients with normal squamous
epithelium, 11 with inflamed squamous epithelium and 23 with Barrete's columnar
lined esophagus were assayed for alkaline phosphatase and disaccharidase activity.
Seven of the patients with Barrett's esophagus had alkaline phosphatase activity
greater than three standard deviations above the mean of the 15 patients with normal
squamous epithelium. Five of these seven also had disaccharidase activity three standard
deviations or greater above normal. One patient with esophagitis, but without
columnar epithelium, had a small increase in alkaline phosphatase and disaccharidase
activity. The production of biochemical markers of small intestinal structure may he
another indicator of the pluripotential nature of Barrett's epithelium. |
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| ISSN: | 0835-7900 |