An Overview of the Therapeutic Potential of Dimeric Flavonoids for Targeting Cancer Hallmarks
Evidence found in the literature indicates that dimeric flavonoids constitute important therapeutic options against cancer. Using these molecules to prevent cancer progression might be a novel and promising therapeutic approach with advantages like fewer side effects, easy access in nature, overall...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | BioChem |
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| Online Access: | https://www.mdpi.com/2673-6411/5/1/2 |
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| _version_ | 1850089922749267968 |
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| author | Inês Lopes Isabel Meireles Rafaela Rocha Rui Medeiros Fátima Cerqueira |
| author_facet | Inês Lopes Isabel Meireles Rafaela Rocha Rui Medeiros Fátima Cerqueira |
| author_sort | Inês Lopes |
| collection | DOAJ |
| description | Evidence found in the literature indicates that dimeric flavonoids constitute important therapeutic options against cancer. Using these molecules to prevent cancer progression might be a novel and promising therapeutic approach with advantages like fewer side effects, easy access in nature, overall health benefits and overcoming drug resistance. Cancer is a complex disease and still not understood, but there are some common mechanisms and biological characteristics underlying tumor progression that have been scrutinized over the years. This information was summarized in a conceptual framework designated as hallmarks of cancer. Dimeric flavonoids exert biological effects in several pathways involved in cancer hallmarks including cell growth, cell cycle, apoptosis, metastasis and metabolism. |
| format | Article |
| id | doaj-art-2b84ecf770624d4b8f711e02e1fd94a4 |
| institution | DOAJ |
| issn | 2673-6411 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | BioChem |
| spelling | doaj-art-2b84ecf770624d4b8f711e02e1fd94a42025-08-20T02:42:39ZengMDPI AGBioChem2673-64112025-01-0151210.3390/biochem5010002An Overview of the Therapeutic Potential of Dimeric Flavonoids for Targeting Cancer HallmarksInês Lopes0Isabel Meireles1Rafaela Rocha2Rui Medeiros3Fátima Cerqueira4Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center (Porto. CCC), Rua Dr. António Bernardino de Almeida, 351, 4200-072 Porto, PortugalMolecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center (Porto. CCC), Rua Dr. António Bernardino de Almeida, 351, 4200-072 Porto, PortugalMolecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center (Porto. CCC), Rua Dr. António Bernardino de Almeida, 351, 4200-072 Porto, PortugalMolecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center (Porto. CCC), Rua Dr. António Bernardino de Almeida, 351, 4200-072 Porto, PortugalMolecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center (Porto. CCC), Rua Dr. António Bernardino de Almeida, 351, 4200-072 Porto, PortugalEvidence found in the literature indicates that dimeric flavonoids constitute important therapeutic options against cancer. Using these molecules to prevent cancer progression might be a novel and promising therapeutic approach with advantages like fewer side effects, easy access in nature, overall health benefits and overcoming drug resistance. Cancer is a complex disease and still not understood, but there are some common mechanisms and biological characteristics underlying tumor progression that have been scrutinized over the years. This information was summarized in a conceptual framework designated as hallmarks of cancer. Dimeric flavonoids exert biological effects in several pathways involved in cancer hallmarks including cell growth, cell cycle, apoptosis, metastasis and metabolism.https://www.mdpi.com/2673-6411/5/1/2cancerdrug resistancedimeric flavonoidshallmarks |
| spellingShingle | Inês Lopes Isabel Meireles Rafaela Rocha Rui Medeiros Fátima Cerqueira An Overview of the Therapeutic Potential of Dimeric Flavonoids for Targeting Cancer Hallmarks BioChem cancer drug resistance dimeric flavonoids hallmarks |
| title | An Overview of the Therapeutic Potential of Dimeric Flavonoids for Targeting Cancer Hallmarks |
| title_full | An Overview of the Therapeutic Potential of Dimeric Flavonoids for Targeting Cancer Hallmarks |
| title_fullStr | An Overview of the Therapeutic Potential of Dimeric Flavonoids for Targeting Cancer Hallmarks |
| title_full_unstemmed | An Overview of the Therapeutic Potential of Dimeric Flavonoids for Targeting Cancer Hallmarks |
| title_short | An Overview of the Therapeutic Potential of Dimeric Flavonoids for Targeting Cancer Hallmarks |
| title_sort | overview of the therapeutic potential of dimeric flavonoids for targeting cancer hallmarks |
| topic | cancer drug resistance dimeric flavonoids hallmarks |
| url | https://www.mdpi.com/2673-6411/5/1/2 |
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