Efficacy and Safety of Tirzepatide in the Treatment of Obesity in Adults: A Comprehensive Review
Obesity is one of the most serious health challenges of the modern world, associated with an increasing incidence and serious health consequences, including cardiovascular diseases and type II diabetes. Pharmacotherapy of obesity is developing rapidly, and tirzepatide, an agonist of GIP and GLP-1 re...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-05-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/60368 |
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| author | Karolina Skonieczna Olimpia Wiciun Kacper Ordon Magdalena Badziąg Paulina Szulc Laura Kurczoba Martyna Kłossowska Olga Kądziołka |
| author_facet | Karolina Skonieczna Olimpia Wiciun Kacper Ordon Magdalena Badziąg Paulina Szulc Laura Kurczoba Martyna Kłossowska Olga Kądziołka |
| author_sort | Karolina Skonieczna |
| collection | DOAJ |
| description | Obesity is one of the most serious health challenges of the modern world, associated with an increasing incidence and serious health consequences, including cardiovascular diseases and type II diabetes. Pharmacotherapy of obesity is developing rapidly, and tirzepatide, an agonist of GIP and GLP-1 receptors, is emerging as a promising solution. In the SURMOUNT and SURPASS clinical trials, tirzepatide was shown to effectively reduce body weight and improve metabolic parameters in diabetic and non-diabetic patients, surpassing other available therapies, such as semaglutide in terms of efficacy. Tirzepatide not only promotes weight loss but also helps maintain the effects achieved and reduces cardiovascular risk, making it an important tool in the treatment of obesity. Its clinical benefits are further enhanced by the introduction of intensive lifestyle interventions before starting therapy. In summary, tirzepatide is an innovative approach to the treatment of obesity, offering promising long-term effects while maintaining a favorable safety profile.
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| format | Article |
| id | doaj-art-2b7f06635cfc4d788b7c3f0e59e96169 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-2b7f06635cfc4d788b7c3f0e59e961692025-08-20T03:52:52ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-05-014110.12775/QS.2025.41.60368Efficacy and Safety of Tirzepatide in the Treatment of Obesity in Adults: A Comprehensive ReviewKarolina Skonieczna0https://orcid.org/0009-0009-0153-7444Olimpia Wiciun1https://orcid.org/0009-0005-0318-5527Kacper Ordon2https://orcid.org/0009-0000-1764-3422Magdalena Badziąg3https://orcid.org/0009-0008-8598-1034Paulina Szulc4https://orcid.org/0009-0007-7614-9214Laura Kurczoba5https://orcid.org/0009-0004-1330-991XMartyna Kłossowska6https://orcid.org/0009-0002-7444-1637Olga Kądziołka7https://orcid.org/0009-0006-1052-4504Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland, Jagiellońska 13/15, 85-067 BydgoszczCollegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland, Jagiellońska 13/15, 85-067 BydgoszczCollegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland, Jagiellońska 13/15, 85-067 BydgoszczUniversity Clinical Center in Gdansk, Poland 80-952 Gdansk, Debinki 7Dr Jan Biziel's University Hospital No. 2 Ujejskiego 75, 85-168 BydgoszczCollegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland, Jagiellońska 13/15, 85-067 BydgoszczBaltic Clinic Sp. z o.o. Wielkokacka 2, 81-611 Gdynia, PolandIndependent Public Health Care Facility in Szamotuły, Sukiennicza 13, 64-500 SzamotułyObesity is one of the most serious health challenges of the modern world, associated with an increasing incidence and serious health consequences, including cardiovascular diseases and type II diabetes. Pharmacotherapy of obesity is developing rapidly, and tirzepatide, an agonist of GIP and GLP-1 receptors, is emerging as a promising solution. In the SURMOUNT and SURPASS clinical trials, tirzepatide was shown to effectively reduce body weight and improve metabolic parameters in diabetic and non-diabetic patients, surpassing other available therapies, such as semaglutide in terms of efficacy. Tirzepatide not only promotes weight loss but also helps maintain the effects achieved and reduces cardiovascular risk, making it an important tool in the treatment of obesity. Its clinical benefits are further enhanced by the introduction of intensive lifestyle interventions before starting therapy. In summary, tirzepatide is an innovative approach to the treatment of obesity, offering promising long-term effects while maintaining a favorable safety profile. https://apcz.umk.pl/QS/article/view/60368Tirzepatide, obesity treatment, pharmacotherapy, GLP-1 and GIP analogs, cardiovascular risk, lifestyle interventions, SURMOUNT, SURPASS |
| spellingShingle | Karolina Skonieczna Olimpia Wiciun Kacper Ordon Magdalena Badziąg Paulina Szulc Laura Kurczoba Martyna Kłossowska Olga Kądziołka Efficacy and Safety of Tirzepatide in the Treatment of Obesity in Adults: A Comprehensive Review Quality in Sport Tirzepatide, obesity treatment, pharmacotherapy, GLP-1 and GIP analogs, cardiovascular risk, lifestyle interventions, SURMOUNT, SURPASS |
| title | Efficacy and Safety of Tirzepatide in the Treatment of Obesity in Adults: A Comprehensive Review |
| title_full | Efficacy and Safety of Tirzepatide in the Treatment of Obesity in Adults: A Comprehensive Review |
| title_fullStr | Efficacy and Safety of Tirzepatide in the Treatment of Obesity in Adults: A Comprehensive Review |
| title_full_unstemmed | Efficacy and Safety of Tirzepatide in the Treatment of Obesity in Adults: A Comprehensive Review |
| title_short | Efficacy and Safety of Tirzepatide in the Treatment of Obesity in Adults: A Comprehensive Review |
| title_sort | efficacy and safety of tirzepatide in the treatment of obesity in adults a comprehensive review |
| topic | Tirzepatide, obesity treatment, pharmacotherapy, GLP-1 and GIP analogs, cardiovascular risk, lifestyle interventions, SURMOUNT, SURPASS |
| url | https://apcz.umk.pl/QS/article/view/60368 |
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