The analysis of schizophrenia-like psychosis in dentatorubral-pallidoluysian atrophy

The analysis of schizophrenia-like psychosis in dentatorubral-pallidoluysian atrophy

BackgroundDentatorubral-pallidoluysian atrophy (DRPLA) is a progressive neurodegenerative disorder caused by expanded CAG repeats in the ATN1 gene, characterized by cerebellar ataxia, seizures, tremors, and myoclonus. Although approximately 10% of patients with DRPLA reportedly develop schizophrenia...

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Main Authors: Ichiko Ikegami, Yuka Mitsuhashi Koike, Hideki Hayashi, Sachiko Hirokawa, Shoichiro Ando, Tomohiko Ishihara, Osamu Onodera
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Neurology
Subjects:
dentatorubral-pallidoluysian atrophy
polyglutamine disease
psychosis
schizophrenia
psychotropic medications
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1564856/full
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