Suppressing phagocyte activation by overexpressing the phosphatidylserine lipase ABHD12 preserves sarmopathic nerves

Suppressing phagocyte activation by overexpressing the phosphatidylserine lipase ABHD12 preserves sarmopathic nerves

Summary: Programmed axon degeneration (AxD) is a hallmark of many neurodegenerative diseases. In healthy axons, NMNAT2 inhibits SARM1, the key executioner of AxD, to keep it from depleting NAD+ and triggering axon destruction. AxD was assumed to be governed by axon-intrinsic mechanisms, independent...

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Bibliographic Details
Main Authors: Caitlin B. Dingwall, Yo Sasaki, Amy Strickland, Tong Wu, Daniel W. Summers, A. Joseph Bloom, Aaron DiAntonio, Jeffrey Milbrandt
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Molecular neuroscience
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225008879
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