Prognostic value of circulating tumor cells in patients with non-small cell lung cancer: a Meta-analysis
Objective To systematically evaluate the prognostic value of circulating tumor cells (CTCs) in patients with non-small cell lung cancer (NSCLC).Methods We electronically searched CNIK, WanFang Data, CBM, VIP, PubMed, Web of Science, The Cochrane Library, and Embase database for literature regarding...
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Editorial Office of New Medicine
2022-08-01
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| Series: | Yixue xinzhi zazhi |
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| Online Access: | https://yxxz.whuznhmedj.com/storage/attach/2208/dmyp4WKzxydm4aKhDBGKKRX4d4pHg7mKjs6mzQGa.pdf |
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| _version_ | 1850105453956038656 |
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| author | Ming-Zhen LI Shao-Hua HE Ying-Hui JIN Cheng CHEN Si-Yu YAN Yong-Bo WANG Huan LIU Zhi-Qing ZHOU Han XIAO Rui-Rui YANG Li-Ming TAN |
| author_facet | Ming-Zhen LI Shao-Hua HE Ying-Hui JIN Cheng CHEN Si-Yu YAN Yong-Bo WANG Huan LIU Zhi-Qing ZHOU Han XIAO Rui-Rui YANG Li-Ming TAN |
| author_sort | Ming-Zhen LI |
| collection | DOAJ |
| description | Objective To systematically evaluate the prognostic value of circulating tumor cells (CTCs) in patients with non-small cell lung cancer (NSCLC).Methods We electronically searched CNIK, WanFang Data, CBM, VIP, PubMed, Web of Science, The Cochrane Library, and Embase database for literature regarding detection of baseline levels of CTCs and survival in NSCLC patients from inception to 28 September 2021. After screening for inclusion criteria, data extraction and quality assessment were performed followed by Meta-analysis using the RevMan 5.3 and Stata 15.0 software.Results 19 studies were included in this Meta-analysis with a total of 1,853 NSCLC patients. Meta-analysis revealed that NSCLC patients with high levels of CTCs had poorer progression-free survival (PFS) than those with low levels of CTCs [HR=2.49, 95% CI(1.50, 4.13), P=0.0004], but levels of CTCs had no significant predictive effect on overall survival (OS) [HR=1.18, 95%CI(0.70, 1.99), P=0.54].Conclusions Baseline CTCs levels have a significant predictive effect on PFS in NSCLC patients, but have no significant predictive ability on OS. This is an area which requires further study in the future. |
| format | Article |
| id | doaj-art-2b71ca4b6a654794b7b3ae015b1c5cd4 |
| institution | OA Journals |
| issn | 1004-5511 |
| language | zho |
| publishDate | 2022-08-01 |
| publisher | Editorial Office of New Medicine |
| record_format | Article |
| series | Yixue xinzhi zazhi |
| spelling | doaj-art-2b71ca4b6a654794b7b3ae015b1c5cd42025-08-20T02:39:04ZzhoEditorial Office of New MedicineYixue xinzhi zazhi1004-55112022-08-0132425025910.12173/j.issn.1004-5511.2022030066336Prognostic value of circulating tumor cells in patients with non-small cell lung cancer: a Meta-analysisMing-Zhen LIShao-Hua HEYing-Hui JINCheng CHENSi-Yu YANYong-Bo WANGHuan LIUZhi-Qing ZHOUHan XIAORui-Rui YANGLi-Ming TANObjective To systematically evaluate the prognostic value of circulating tumor cells (CTCs) in patients with non-small cell lung cancer (NSCLC).Methods We electronically searched CNIK, WanFang Data, CBM, VIP, PubMed, Web of Science, The Cochrane Library, and Embase database for literature regarding detection of baseline levels of CTCs and survival in NSCLC patients from inception to 28 September 2021. After screening for inclusion criteria, data extraction and quality assessment were performed followed by Meta-analysis using the RevMan 5.3 and Stata 15.0 software.Results 19 studies were included in this Meta-analysis with a total of 1,853 NSCLC patients. Meta-analysis revealed that NSCLC patients with high levels of CTCs had poorer progression-free survival (PFS) than those with low levels of CTCs [HR=2.49, 95% CI(1.50, 4.13), P=0.0004], but levels of CTCs had no significant predictive effect on overall survival (OS) [HR=1.18, 95%CI(0.70, 1.99), P=0.54].Conclusions Baseline CTCs levels have a significant predictive effect on PFS in NSCLC patients, but have no significant predictive ability on OS. This is an area which requires further study in the future.https://yxxz.whuznhmedj.com/storage/attach/2208/dmyp4WKzxydm4aKhDBGKKRX4d4pHg7mKjs6mzQGa.pdfcirculating tumor cell non-small cell lung cancer prognosis meta-analysis |
| spellingShingle | Ming-Zhen LI Shao-Hua HE Ying-Hui JIN Cheng CHEN Si-Yu YAN Yong-Bo WANG Huan LIU Zhi-Qing ZHOU Han XIAO Rui-Rui YANG Li-Ming TAN Prognostic value of circulating tumor cells in patients with non-small cell lung cancer: a Meta-analysis Yixue xinzhi zazhi circulating tumor cell non-small cell lung cancer prognosis meta-analysis |
| title | Prognostic value of circulating tumor cells in patients with non-small cell lung cancer: a Meta-analysis |
| title_full | Prognostic value of circulating tumor cells in patients with non-small cell lung cancer: a Meta-analysis |
| title_fullStr | Prognostic value of circulating tumor cells in patients with non-small cell lung cancer: a Meta-analysis |
| title_full_unstemmed | Prognostic value of circulating tumor cells in patients with non-small cell lung cancer: a Meta-analysis |
| title_short | Prognostic value of circulating tumor cells in patients with non-small cell lung cancer: a Meta-analysis |
| title_sort | prognostic value of circulating tumor cells in patients with non small cell lung cancer a meta analysis |
| topic | circulating tumor cell non-small cell lung cancer prognosis meta-analysis |
| url | https://yxxz.whuznhmedj.com/storage/attach/2208/dmyp4WKzxydm4aKhDBGKKRX4d4pHg7mKjs6mzQGa.pdf |
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