Oncogenic PIK3CA corrupts growth factor signaling specificity

Oncogenic PIK3CA corrupts growth factor signaling specificity

Abstract Technical limitations have prevented understanding of how growth factor signals are encoded in distinct activity patterns of the phosphoinositide 3-kinase (PI3K)/AKT pathway, and how this is altered by oncogenic pathway mutations. We introduce a kinetic, single-cell framework for precise ca...

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Bibliographic Details
Main Authors: Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck
Format: Article
Language:English
Published: Springer Nature 2024-12-01
Series:Molecular Systems Biology
Subjects:
PI3K Signaling Dynamics
Information Transfer
Growth Factor Specificity
Single-cell Biology
Online Access:https://doi.org/10.1038/s44320-024-00078-x
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