Grading of Age-Related Macular Degeneration: Comparison between Color Fundus Photography, Fluorescein Angiography, and Spectral Domain Optical Coherence Tomography
Purpose. To compare color fundus photography (FP), fluorescein angiography (FA), and spectral domain optical coherence tomography (SDOCT) for the detection of age-related macular degeneration (AMD), choroidal neovascularisation (CNV), and CNV activity. Methods. FPs, FAs, and SDOCT volume scans from...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2013/385915 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850228573206478848 |
|---|---|
| author | Nils F. Mokwa Tina Ristau Pearse A. Keane Bernd Kirchhof Srinivas R. Sadda Sandra Liakopoulos |
| author_facet | Nils F. Mokwa Tina Ristau Pearse A. Keane Bernd Kirchhof Srinivas R. Sadda Sandra Liakopoulos |
| author_sort | Nils F. Mokwa |
| collection | DOAJ |
| description | Purpose. To compare color fundus photography (FP), fluorescein angiography (FA), and spectral domain optical coherence tomography (SDOCT) for the detection of age-related macular degeneration (AMD), choroidal neovascularisation (CNV), and CNV activity. Methods. FPs, FAs, and SDOCT volume scans from 120 eyes of 66 AMD and control patients were randomly collected. Control eyes were required to show no AMD, but other retinal pathology was allowed. The presence of drusen, pigmentary changes, CNV, and signs for CNV activity was independently analyzed for all imaging modalities. Results. AMD was diagnosed based on FP in 75 eyes. SDOCT and FA showed sensitivity (specificity) of 89% (76%) and 92% (82%), respectively. CNV was present on FA in 68 eyes. Sensitivity (specificity) was 78% (100%) for FP and 94% (98%) for SDOCT. CNV activity was detected by SDOCT or FA in 60 eyes with an agreement in 46 eyes. Sensitivity was 88% for SDOCT and 88% for FA. FP showed sensitivity of 38% and specificity of 98%. Conclusions. CNV lesions and activity may be missed by FP alone, but FP may help identifying drusen and pigmentary changes. SDOCT is highly sensitive for the detection of AMD, CNV, and CNV activity; however, it cannot fully replace FA. |
| format | Article |
| id | doaj-art-2b65fd35a9624b349d1dc788a1e746fa |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-2b65fd35a9624b349d1dc788a1e746fa2025-08-20T02:04:30ZengWileyJournal of Ophthalmology2090-004X2090-00582013-01-01201310.1155/2013/385915385915Grading of Age-Related Macular Degeneration: Comparison between Color Fundus Photography, Fluorescein Angiography, and Spectral Domain Optical Coherence TomographyNils F. Mokwa0Tina Ristau1Pearse A. Keane2Bernd Kirchhof3Srinivas R. Sadda4Sandra Liakopoulos5Cologne Image Reading Center and Laboratory, Department of Ophthalmology, University of Cologne, 50924 Cologne, GermanyCologne Image Reading Center and Laboratory, Department of Ophthalmology, University of Cologne, 50924 Cologne, GermanyBiomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London EC1V 2PD, UKCologne Image Reading Center and Laboratory, Department of Ophthalmology, University of Cologne, 50924 Cologne, GermanyDoheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USACologne Image Reading Center and Laboratory, Department of Ophthalmology, University of Cologne, 50924 Cologne, GermanyPurpose. To compare color fundus photography (FP), fluorescein angiography (FA), and spectral domain optical coherence tomography (SDOCT) for the detection of age-related macular degeneration (AMD), choroidal neovascularisation (CNV), and CNV activity. Methods. FPs, FAs, and SDOCT volume scans from 120 eyes of 66 AMD and control patients were randomly collected. Control eyes were required to show no AMD, but other retinal pathology was allowed. The presence of drusen, pigmentary changes, CNV, and signs for CNV activity was independently analyzed for all imaging modalities. Results. AMD was diagnosed based on FP in 75 eyes. SDOCT and FA showed sensitivity (specificity) of 89% (76%) and 92% (82%), respectively. CNV was present on FA in 68 eyes. Sensitivity (specificity) was 78% (100%) for FP and 94% (98%) for SDOCT. CNV activity was detected by SDOCT or FA in 60 eyes with an agreement in 46 eyes. Sensitivity was 88% for SDOCT and 88% for FA. FP showed sensitivity of 38% and specificity of 98%. Conclusions. CNV lesions and activity may be missed by FP alone, but FP may help identifying drusen and pigmentary changes. SDOCT is highly sensitive for the detection of AMD, CNV, and CNV activity; however, it cannot fully replace FA.http://dx.doi.org/10.1155/2013/385915 |
| spellingShingle | Nils F. Mokwa Tina Ristau Pearse A. Keane Bernd Kirchhof Srinivas R. Sadda Sandra Liakopoulos Grading of Age-Related Macular Degeneration: Comparison between Color Fundus Photography, Fluorescein Angiography, and Spectral Domain Optical Coherence Tomography Journal of Ophthalmology |
| title | Grading of Age-Related Macular Degeneration: Comparison between Color Fundus Photography, Fluorescein Angiography, and Spectral Domain Optical Coherence Tomography |
| title_full | Grading of Age-Related Macular Degeneration: Comparison between Color Fundus Photography, Fluorescein Angiography, and Spectral Domain Optical Coherence Tomography |
| title_fullStr | Grading of Age-Related Macular Degeneration: Comparison between Color Fundus Photography, Fluorescein Angiography, and Spectral Domain Optical Coherence Tomography |
| title_full_unstemmed | Grading of Age-Related Macular Degeneration: Comparison between Color Fundus Photography, Fluorescein Angiography, and Spectral Domain Optical Coherence Tomography |
| title_short | Grading of Age-Related Macular Degeneration: Comparison between Color Fundus Photography, Fluorescein Angiography, and Spectral Domain Optical Coherence Tomography |
| title_sort | grading of age related macular degeneration comparison between color fundus photography fluorescein angiography and spectral domain optical coherence tomography |
| url | http://dx.doi.org/10.1155/2013/385915 |
| work_keys_str_mv | AT nilsfmokwa gradingofagerelatedmaculardegenerationcomparisonbetweencolorfundusphotographyfluoresceinangiographyandspectraldomainopticalcoherencetomography AT tinaristau gradingofagerelatedmaculardegenerationcomparisonbetweencolorfundusphotographyfluoresceinangiographyandspectraldomainopticalcoherencetomography AT pearseakeane gradingofagerelatedmaculardegenerationcomparisonbetweencolorfundusphotographyfluoresceinangiographyandspectraldomainopticalcoherencetomography AT berndkirchhof gradingofagerelatedmaculardegenerationcomparisonbetweencolorfundusphotographyfluoresceinangiographyandspectraldomainopticalcoherencetomography AT srinivasrsadda gradingofagerelatedmaculardegenerationcomparisonbetweencolorfundusphotographyfluoresceinangiographyandspectraldomainopticalcoherencetomography AT sandraliakopoulos gradingofagerelatedmaculardegenerationcomparisonbetweencolorfundusphotographyfluoresceinangiographyandspectraldomainopticalcoherencetomography |