Anemia in Pregnancy With CKD
Chronic kidney disease (CKD), anemia, and iron deficiency are global health issues affecting individuals in both high-income and low-income countries. In pregnancy, both CKD and iron deficiency anemia increase the risk of adverse maternal and neonatal outcomes, including increased maternal morbidity...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Kidney International Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468024924000160 |
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| author | Margriet F.C. de Jong Elizabeta Nemeth Pien Rawee Kate Bramham Michele F. Eisenga |
| author_facet | Margriet F.C. de Jong Elizabeta Nemeth Pien Rawee Kate Bramham Michele F. Eisenga |
| author_sort | Margriet F.C. de Jong |
| collection | DOAJ |
| description | Chronic kidney disease (CKD), anemia, and iron deficiency are global health issues affecting individuals in both high-income and low-income countries. In pregnancy, both CKD and iron deficiency anemia increase the risk of adverse maternal and neonatal outcomes, including increased maternal morbidity and mortality, stillbirth, perinatal death, preterm birth, and low birthweight. However, it is unknown to which extent iron deficiency anemia contributes to adverse outcomes in CKD pregnancy. Furthermore, little is known regarding the prevalence, pathophysiology, and treatment of iron deficiency and anemia in pregnant women with CKD. Therefore, there are many unanswered questions regarding optimal management with oral or i.v. iron and recombinant human erythropoietin (rhEPO) in these women. In this review, we present a short overview of the (patho)physiology of anemia in healthy pregnancy and in people living with CKD. We present an evaluation of the literature on iron deficiency, anemia, and nutritional deficits in pregnant women with CKD; and we evaluate current knowledge gaps. Finally, we propose research priorities regarding anemia in pregnant women with CKD. |
| format | Article |
| id | doaj-art-2b655be5a3c5407983e16212ebdaead1 |
| institution | DOAJ |
| issn | 2468-0249 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney International Reports |
| spelling | doaj-art-2b655be5a3c5407983e16212ebdaead12025-08-20T03:20:19ZengElsevierKidney International Reports2468-02492024-05-01951183119710.1016/j.ekir.2024.01.015Anemia in Pregnancy With CKDMargriet F.C. de Jong0Elizabeta Nemeth1Pien Rawee2Kate Bramham3Michele F. Eisenga4Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, The Netherlands; Correspondence: Margriet F. C. de Jong, Division of Nephrology Groningen, Department of Internal Medicine, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.Department of Medicine, University of California, Los Angeles, California, USADepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, The NetherlandsDepartment of Women and Children’s Health, King’s College London, London, UKDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, The NetherlandsChronic kidney disease (CKD), anemia, and iron deficiency are global health issues affecting individuals in both high-income and low-income countries. In pregnancy, both CKD and iron deficiency anemia increase the risk of adverse maternal and neonatal outcomes, including increased maternal morbidity and mortality, stillbirth, perinatal death, preterm birth, and low birthweight. However, it is unknown to which extent iron deficiency anemia contributes to adverse outcomes in CKD pregnancy. Furthermore, little is known regarding the prevalence, pathophysiology, and treatment of iron deficiency and anemia in pregnant women with CKD. Therefore, there are many unanswered questions regarding optimal management with oral or i.v. iron and recombinant human erythropoietin (rhEPO) in these women. In this review, we present a short overview of the (patho)physiology of anemia in healthy pregnancy and in people living with CKD. We present an evaluation of the literature on iron deficiency, anemia, and nutritional deficits in pregnant women with CKD; and we evaluate current knowledge gaps. Finally, we propose research priorities regarding anemia in pregnant women with CKD.http://www.sciencedirect.com/science/article/pii/S2468024924000160anemiaCKDhepcidinironkidney diseasepregnancy |
| spellingShingle | Margriet F.C. de Jong Elizabeta Nemeth Pien Rawee Kate Bramham Michele F. Eisenga Anemia in Pregnancy With CKD Kidney International Reports anemia CKD hepcidin iron kidney disease pregnancy |
| title | Anemia in Pregnancy With CKD |
| title_full | Anemia in Pregnancy With CKD |
| title_fullStr | Anemia in Pregnancy With CKD |
| title_full_unstemmed | Anemia in Pregnancy With CKD |
| title_short | Anemia in Pregnancy With CKD |
| title_sort | anemia in pregnancy with ckd |
| topic | anemia CKD hepcidin iron kidney disease pregnancy |
| url | http://www.sciencedirect.com/science/article/pii/S2468024924000160 |
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