Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection.

Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection.

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus causing fever, myalgia, and debilitating joint swelling and pain, which in many patients becomes chronic. The frequent epidemics of CHIKV across the world pose a significant public health burden necessitating the development of effective...

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Main Authors: Kiran Bala Sharma, Chandru Subramani, Khashpatika Ganesh, Anshula Sharma, Brohmomoy Basu, Shivani Balyan, Ghanshyam Sharma, Shouri Ka, Arundhati Deb, Mitul Srivastava, Saurabh Chugh, Sapna Sehrawat, Kanchan Bharadwaj, Archana Rout, Pankaj Kumar Sahoo, Suman Saurav, Rajender K Motiani, Ramandeep Singh, Deepti Jain, Shailendra Asthana, Renu Wadhwa, Sudhanshu Vrati
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012816
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