Abortive vampire bat rabies infections in Peruvian peridomestic livestock.
Rabies virus infections normally cause universally lethal encephalitis across mammals. However, 'abortive infections' which are resolved prior to the onset of lethal disease have been described in bats and a variety of non-reservoir species. Here, we surveyed rabies virus neutralizing anti...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-06-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0008194&type=printable |
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| author | Julio A Benavides Andres Velasco-Villa Lauren C Godino Panayampalli Subbian Satheshkumar Ruby Nino Elizabeth Rojas-Paniagua Carlos Shiva Nestor Falcon Daniel G Streicker |
| author_facet | Julio A Benavides Andres Velasco-Villa Lauren C Godino Panayampalli Subbian Satheshkumar Ruby Nino Elizabeth Rojas-Paniagua Carlos Shiva Nestor Falcon Daniel G Streicker |
| author_sort | Julio A Benavides |
| collection | DOAJ |
| description | Rabies virus infections normally cause universally lethal encephalitis across mammals. However, 'abortive infections' which are resolved prior to the onset of lethal disease have been described in bats and a variety of non-reservoir species. Here, we surveyed rabies virus neutralizing antibody titers in 332 unvaccinated livestock of 5 species from a vampire bat rabies endemic region of southern Peru where livestock are the main food source for bats. We detected rabies virus neutralizing antibody titers in 11, 5 and 3.6% of cows, goats and sheep respectively and seropositive animals did not die from rabies within two years after sampling. Seroprevalence was correlated with the number of local livestock rabies mortalities reported one year prior but also one year after sample collection. This suggests that serological status of livestock can indicate the past and future levels of rabies risk to non-reservoir hosts. To our knowledge, this is the first report of anti-rabies antibodies among goats and sheep, suggesting widespread abortive infections among livestock in vampire bat rabies endemic areas. Future research should resolve the within-host biology underlying clearance of rabies infections. Cost-effectiveness analyses are also needed to evaluate whether serological monitoring of livestock can be a viable complement to current monitoring of vampire bat rabies risk based on animal mortalities alone. |
| format | Article |
| id | doaj-art-2b5f639cbfc34cce9fbb928b2bccc36c |
| institution | Kabale University |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-2b5f639cbfc34cce9fbb928b2bccc36c2025-08-23T05:33:11ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352020-06-01146e000819410.1371/journal.pntd.0008194Abortive vampire bat rabies infections in Peruvian peridomestic livestock.Julio A BenavidesAndres Velasco-VillaLauren C GodinoPanayampalli Subbian SatheshkumarRuby NinoElizabeth Rojas-PaniaguaCarlos ShivaNestor FalconDaniel G StreickerRabies virus infections normally cause universally lethal encephalitis across mammals. However, 'abortive infections' which are resolved prior to the onset of lethal disease have been described in bats and a variety of non-reservoir species. Here, we surveyed rabies virus neutralizing antibody titers in 332 unvaccinated livestock of 5 species from a vampire bat rabies endemic region of southern Peru where livestock are the main food source for bats. We detected rabies virus neutralizing antibody titers in 11, 5 and 3.6% of cows, goats and sheep respectively and seropositive animals did not die from rabies within two years after sampling. Seroprevalence was correlated with the number of local livestock rabies mortalities reported one year prior but also one year after sample collection. This suggests that serological status of livestock can indicate the past and future levels of rabies risk to non-reservoir hosts. To our knowledge, this is the first report of anti-rabies antibodies among goats and sheep, suggesting widespread abortive infections among livestock in vampire bat rabies endemic areas. Future research should resolve the within-host biology underlying clearance of rabies infections. Cost-effectiveness analyses are also needed to evaluate whether serological monitoring of livestock can be a viable complement to current monitoring of vampire bat rabies risk based on animal mortalities alone.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0008194&type=printable |
| spellingShingle | Julio A Benavides Andres Velasco-Villa Lauren C Godino Panayampalli Subbian Satheshkumar Ruby Nino Elizabeth Rojas-Paniagua Carlos Shiva Nestor Falcon Daniel G Streicker Abortive vampire bat rabies infections in Peruvian peridomestic livestock. PLoS Neglected Tropical Diseases |
| title | Abortive vampire bat rabies infections in Peruvian peridomestic livestock. |
| title_full | Abortive vampire bat rabies infections in Peruvian peridomestic livestock. |
| title_fullStr | Abortive vampire bat rabies infections in Peruvian peridomestic livestock. |
| title_full_unstemmed | Abortive vampire bat rabies infections in Peruvian peridomestic livestock. |
| title_short | Abortive vampire bat rabies infections in Peruvian peridomestic livestock. |
| title_sort | abortive vampire bat rabies infections in peruvian peridomestic livestock |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0008194&type=printable |
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