Effects of a <i>Saccharomyces cerevisiae</i>-Derived Postbiotic in Adult Labrador Retrievers Undergoing Exercise and Transport Stress
Postbiotics are emerging as potential functional ingredients for companion animal diets. This study aimed to determine if a <i>Saccharomyces cerevisiae</i>-based postbiotic can alter cytokine and stress responses to exercise and transport stress in adult Labrador Retrievers. Dogs receive...
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MDPI AG
2024-11-01
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| Series: | Pets |
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| Online Access: | https://www.mdpi.com/2813-9372/1/3/25 |
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| author | Claire L. Timlin Fiona B. Mccracken Sarah M. Dickerson Patrick M. Skaggs Jason W. Fowler Sangita Jalukar Craig N. Coon |
| author_facet | Claire L. Timlin Fiona B. Mccracken Sarah M. Dickerson Patrick M. Skaggs Jason W. Fowler Sangita Jalukar Craig N. Coon |
| author_sort | Claire L. Timlin |
| collection | DOAJ |
| description | Postbiotics are emerging as potential functional ingredients for companion animal diets. This study aimed to determine if a <i>Saccharomyces cerevisiae</i>-based postbiotic can alter cytokine and stress responses to exercise and transport stress in adult Labrador Retrievers. Dogs received 15 g ground corn germ (Control, n = 12), 7.5 g postbiotic (Low, n = 12), or 15 g postbiotic (High, n = 12), daily for 63 days. Exercise was twice weekly for 7 weeks, and a single transport per dog occurred in week 8. Fecal inflammatory biomarkers, serum chemistries, and complete blood counts were assessed at the beginning and end of the study. Serum cytokines were quantified before and 18–20 h after the first and last exercise runs. Gait analysis was assessed before and 24 h after the first and final runs. Saliva cortisol was measured before and after transportation. Treatment did not affect blood chemistries, gait, fecal biomarkers, or saliva cortisol (<i>p</i> ≥ 0.19). Eosinophils increased slightly in Controls (<i>p</i> = 0.01), though remained below 0.80 × 10<sup>9</sup> cells/L. Most cytokines were unaffected by treatment (<i>p</i> ≥ 0.15), but there were minor changes in circulating monocyte chemoattractant protein-1 (<i>p</i> = 0.01) and IL-8 over time at the initial run (<i>p</i> = 0.03) and IL-10 in males (<i>p</i> = 0.02) in the Low dose dogs. The High dose decreased <i>Blautia</i> (<i>p</i> = 0.04) slightly and tended to decrease <i>Fusobacterium</i> abundances (<i>p</i> = 0.07). The Low dose tended to increase <i>Clostridium hiranonis</i> (<i>p</i> = 0.07) slightly. The tested <i>S. cerevisiae</i> postbiotic produced small changes in immune function and gut microbial species in dogs. |
| format | Article |
| id | doaj-art-2b5d7c3a925e4fe09bb57b546313549b |
| institution | OA Journals |
| issn | 2813-9372 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Pets |
| spelling | doaj-art-2b5d7c3a925e4fe09bb57b546313549b2025-08-20T02:04:06ZengMDPI AGPets2813-93722024-11-011335037110.3390/pets1030025Effects of a <i>Saccharomyces cerevisiae</i>-Derived Postbiotic in Adult Labrador Retrievers Undergoing Exercise and Transport StressClaire L. Timlin0Fiona B. Mccracken1Sarah M. Dickerson2Patrick M. Skaggs3Jason W. Fowler4Sangita Jalukar5Craig N. Coon6Four Rivers Kennel LLC, Walker, MO 64790, USAFour Rivers Kennel LLC, Walker, MO 64790, USAFour Rivers Kennel LLC, Walker, MO 64790, USAFour Rivers Kennel LLC, Walker, MO 64790, USAFour Rivers Kennel LLC, Walker, MO 64790, USAArm & Hammer Animal and Food Production, Church and Dwight Co., Inc., Ewing, NJ 08628, USAFour Rivers Kennel LLC, Walker, MO 64790, USAPostbiotics are emerging as potential functional ingredients for companion animal diets. This study aimed to determine if a <i>Saccharomyces cerevisiae</i>-based postbiotic can alter cytokine and stress responses to exercise and transport stress in adult Labrador Retrievers. Dogs received 15 g ground corn germ (Control, n = 12), 7.5 g postbiotic (Low, n = 12), or 15 g postbiotic (High, n = 12), daily for 63 days. Exercise was twice weekly for 7 weeks, and a single transport per dog occurred in week 8. Fecal inflammatory biomarkers, serum chemistries, and complete blood counts were assessed at the beginning and end of the study. Serum cytokines were quantified before and 18–20 h after the first and last exercise runs. Gait analysis was assessed before and 24 h after the first and final runs. Saliva cortisol was measured before and after transportation. Treatment did not affect blood chemistries, gait, fecal biomarkers, or saliva cortisol (<i>p</i> ≥ 0.19). Eosinophils increased slightly in Controls (<i>p</i> = 0.01), though remained below 0.80 × 10<sup>9</sup> cells/L. Most cytokines were unaffected by treatment (<i>p</i> ≥ 0.15), but there were minor changes in circulating monocyte chemoattractant protein-1 (<i>p</i> = 0.01) and IL-8 over time at the initial run (<i>p</i> = 0.03) and IL-10 in males (<i>p</i> = 0.02) in the Low dose dogs. The High dose decreased <i>Blautia</i> (<i>p</i> = 0.04) slightly and tended to decrease <i>Fusobacterium</i> abundances (<i>p</i> = 0.07). The Low dose tended to increase <i>Clostridium hiranonis</i> (<i>p</i> = 0.07) slightly. The tested <i>S. cerevisiae</i> postbiotic produced small changes in immune function and gut microbial species in dogs.https://www.mdpi.com/2813-9372/1/3/25<i>Saccharomyces cerevisiae</i>doginflammatory cytokinesexercise |
| spellingShingle | Claire L. Timlin Fiona B. Mccracken Sarah M. Dickerson Patrick M. Skaggs Jason W. Fowler Sangita Jalukar Craig N. Coon Effects of a <i>Saccharomyces cerevisiae</i>-Derived Postbiotic in Adult Labrador Retrievers Undergoing Exercise and Transport Stress Pets <i>Saccharomyces cerevisiae</i> dog inflammatory cytokines exercise |
| title | Effects of a <i>Saccharomyces cerevisiae</i>-Derived Postbiotic in Adult Labrador Retrievers Undergoing Exercise and Transport Stress |
| title_full | Effects of a <i>Saccharomyces cerevisiae</i>-Derived Postbiotic in Adult Labrador Retrievers Undergoing Exercise and Transport Stress |
| title_fullStr | Effects of a <i>Saccharomyces cerevisiae</i>-Derived Postbiotic in Adult Labrador Retrievers Undergoing Exercise and Transport Stress |
| title_full_unstemmed | Effects of a <i>Saccharomyces cerevisiae</i>-Derived Postbiotic in Adult Labrador Retrievers Undergoing Exercise and Transport Stress |
| title_short | Effects of a <i>Saccharomyces cerevisiae</i>-Derived Postbiotic in Adult Labrador Retrievers Undergoing Exercise and Transport Stress |
| title_sort | effects of a i saccharomyces cerevisiae i derived postbiotic in adult labrador retrievers undergoing exercise and transport stress |
| topic | <i>Saccharomyces cerevisiae</i> dog inflammatory cytokines exercise |
| url | https://www.mdpi.com/2813-9372/1/3/25 |
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