Polypeptides-Based Nanocarriers in Tumor Therapy
Cancer remains a worldwide problem, and new treatment strategies are being actively developed. Peptides have the characteristics of good biocompatibility, strong targeting, functional diversity, modifiability, membrane permeable ability, and low immunogenicity, and they have been widely used to cons...
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MDPI AG
2024-09-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/9/1192 |
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| author | Juhua You Yifei Guo Zhengqi Dong |
| author_facet | Juhua You Yifei Guo Zhengqi Dong |
| author_sort | Juhua You |
| collection | DOAJ |
| description | Cancer remains a worldwide problem, and new treatment strategies are being actively developed. Peptides have the characteristics of good biocompatibility, strong targeting, functional diversity, modifiability, membrane permeable ability, and low immunogenicity, and they have been widely used to construct targeted drug delivery systems (DDSs). In addition, peptides, as endogenous substances, have a high affinity, which can not only regulate immune cells but also work synergistically with drugs to kill tumor cells, demonstrating significant potential for application. In this review, the latest progress of polypeptides-based nanocarriers in tumor therapy has been outlined, focusing on their applications in killing tumor cells and regulating immune cells. Additionally, peptides as carriers were found to primarily provide a transport function, which was also a subject of interest to us. At the end of the paper, the shortcomings in the construction of peptide nano-delivery system have been summarized, and possible solutions are proposed therein. The application of peptides provides a promising outlook for cancer treatment, and we hope this article can provide in-depth insights into possible future avenues of exploration. |
| format | Article |
| id | doaj-art-2b5ad2015d2b418785c784c9e8daff0f |
| institution | OA Journals |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-2b5ad2015d2b418785c784c9e8daff0f2025-08-20T01:55:46ZengMDPI AGPharmaceutics1999-49232024-09-01169119210.3390/pharmaceutics16091192Polypeptides-Based Nanocarriers in Tumor TherapyJuhua You0Yifei Guo1Zhengqi Dong2School of Pharmacy, Heilongjiang University of Chinese Medicine, No. 24, Heping Road, Xiangfang District, Harbin 150040, ChinaSchool of Pharmacy, Heilongjiang University of Chinese Medicine, No. 24, Heping Road, Xiangfang District, Harbin 150040, ChinaSchool of Pharmacy, Heilongjiang University of Chinese Medicine, No. 24, Heping Road, Xiangfang District, Harbin 150040, ChinaCancer remains a worldwide problem, and new treatment strategies are being actively developed. Peptides have the characteristics of good biocompatibility, strong targeting, functional diversity, modifiability, membrane permeable ability, and low immunogenicity, and they have been widely used to construct targeted drug delivery systems (DDSs). In addition, peptides, as endogenous substances, have a high affinity, which can not only regulate immune cells but also work synergistically with drugs to kill tumor cells, demonstrating significant potential for application. In this review, the latest progress of polypeptides-based nanocarriers in tumor therapy has been outlined, focusing on their applications in killing tumor cells and regulating immune cells. Additionally, peptides as carriers were found to primarily provide a transport function, which was also a subject of interest to us. At the end of the paper, the shortcomings in the construction of peptide nano-delivery system have been summarized, and possible solutions are proposed therein. The application of peptides provides a promising outlook for cancer treatment, and we hope this article can provide in-depth insights into possible future avenues of exploration.https://www.mdpi.com/1999-4923/16/9/1192polypeptides-based nanocarriersdrug delivery systemsantitumorimmunomodulationchallenge |
| spellingShingle | Juhua You Yifei Guo Zhengqi Dong Polypeptides-Based Nanocarriers in Tumor Therapy Pharmaceutics polypeptides-based nanocarriers drug delivery systems antitumor immunomodulation challenge |
| title | Polypeptides-Based Nanocarriers in Tumor Therapy |
| title_full | Polypeptides-Based Nanocarriers in Tumor Therapy |
| title_fullStr | Polypeptides-Based Nanocarriers in Tumor Therapy |
| title_full_unstemmed | Polypeptides-Based Nanocarriers in Tumor Therapy |
| title_short | Polypeptides-Based Nanocarriers in Tumor Therapy |
| title_sort | polypeptides based nanocarriers in tumor therapy |
| topic | polypeptides-based nanocarriers drug delivery systems antitumor immunomodulation challenge |
| url | https://www.mdpi.com/1999-4923/16/9/1192 |
| work_keys_str_mv | AT juhuayou polypeptidesbasednanocarriersintumortherapy AT yifeiguo polypeptidesbasednanocarriersintumortherapy AT zhengqidong polypeptidesbasednanocarriersintumortherapy |