Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adults
Abstract Background Surfactant Protein D (SP‐D) is a pattern recognition molecule belonging to the family of collectins expressed in multiple human organ systems, including the lungs. Previous studies have shown that SP‐D levels in bronchoalveolar lavage samples decrease and serum levels increase in...
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Wiley
2022-02-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.560 |
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| author | Benjamin Hoffmann‐Petersen Raymond Suffolk Jens J. H. Petersen Thomas H. Petersen Charlotte Brasch‐Andersen Arne Høst Susanne Halken Grith L. Sorensen Lone Agertoft |
| author_facet | Benjamin Hoffmann‐Petersen Raymond Suffolk Jens J. H. Petersen Thomas H. Petersen Charlotte Brasch‐Andersen Arne Høst Susanne Halken Grith L. Sorensen Lone Agertoft |
| author_sort | Benjamin Hoffmann‐Petersen |
| collection | DOAJ |
| description | Abstract Background Surfactant Protein D (SP‐D) is a pattern recognition molecule belonging to the family of collectins expressed in multiple human organ systems, including the lungs. Previous studies have shown that SP‐D levels in bronchoalveolar lavage samples decrease and serum levels increase in patients suffering from asthma, possibly due to a combination of induced SP‐D synthesis and decreased air–blood barrier integrity. The aims of this study were to investigate whether serum levels of SP‐D and common variants in the SP‐D gene were associated with asthma in adolescents and young adults. Methods Prospective observational study including 449 adolescents and young adults (age 11–27 years) previously diagnosed with asthma during a 2‐year period from 2003 to 2005 (0–16 years). At follow‐up from 2016 to 2017, 314 healthy controls with no history of asthma were recruited. Serum SP‐D was analyzed on samples obtained at baseline as well as samples obtained at follow‐up. SP‐D genotyping was performed for rs721917, rs2243639, and rs3088308. Results No differences were found in mean levels of sSP‐D and SFTPD genotype among subjects with current asthma, no current asthma, and controls. Serum SP‐D and SFTPD genotype were not associated with any clinical parameters of asthma. Furthermore, baseline sSP‐D was not associated with asthma at follow‐up. Conclusion Serum surfactant protein D and common SP‐D gene variants were not associated with asthma in Danish adolescents and young adults with mild to moderate asthma. Serum surfactant protein D did not demonstrate any value as a clinical biomarker of asthma. |
| format | Article |
| id | doaj-art-2b58bfb7f3ea45d7b8c9bd2793ebb864 |
| institution | OA Journals |
| issn | 2050-4527 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | Wiley |
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| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-2b58bfb7f3ea45d7b8c9bd2793ebb8642025-08-20T02:25:51ZengWileyImmunity, Inflammation and Disease2050-45272022-02-0110218920010.1002/iid3.560Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adultsBenjamin Hoffmann‐Petersen0Raymond Suffolk1Jens J. H. Petersen2Thomas H. Petersen3Charlotte Brasch‐Andersen4Arne Høst5Susanne Halken6Grith L. Sorensen7Lone Agertoft8Hans Christian Andersen Children's Hospital Odense University Hospital Odense DenmarkDepartment of Pediatrics Hospital of Southern Jutland Aabenraa DenmarkDepartment of Pediatrics Hospital of Southern Jutland Esbjerg DenmarkDepartment of Pediatrics Hospital of Southern Jutland Kolding DenmarkDepartment of Clinical Genetics Odense University Hospital Odense DenmarkHans Christian Andersen Children's Hospital Odense University Hospital Odense DenmarkHans Christian Andersen Children's Hospital Odense University Hospital Odense DenmarkInstitute of Molecular Medicine University of Southern Denmark Odense DenmarkHans Christian Andersen Children's Hospital Odense University Hospital Odense DenmarkAbstract Background Surfactant Protein D (SP‐D) is a pattern recognition molecule belonging to the family of collectins expressed in multiple human organ systems, including the lungs. Previous studies have shown that SP‐D levels in bronchoalveolar lavage samples decrease and serum levels increase in patients suffering from asthma, possibly due to a combination of induced SP‐D synthesis and decreased air–blood barrier integrity. The aims of this study were to investigate whether serum levels of SP‐D and common variants in the SP‐D gene were associated with asthma in adolescents and young adults. Methods Prospective observational study including 449 adolescents and young adults (age 11–27 years) previously diagnosed with asthma during a 2‐year period from 2003 to 2005 (0–16 years). At follow‐up from 2016 to 2017, 314 healthy controls with no history of asthma were recruited. Serum SP‐D was analyzed on samples obtained at baseline as well as samples obtained at follow‐up. SP‐D genotyping was performed for rs721917, rs2243639, and rs3088308. Results No differences were found in mean levels of sSP‐D and SFTPD genotype among subjects with current asthma, no current asthma, and controls. Serum SP‐D and SFTPD genotype were not associated with any clinical parameters of asthma. Furthermore, baseline sSP‐D was not associated with asthma at follow‐up. Conclusion Serum surfactant protein D and common SP‐D gene variants were not associated with asthma in Danish adolescents and young adults with mild to moderate asthma. Serum surfactant protein D did not demonstrate any value as a clinical biomarker of asthma.https://doi.org/10.1002/iid3.560adolescentasthmabiomarkerchildsurfactant protein D |
| spellingShingle | Benjamin Hoffmann‐Petersen Raymond Suffolk Jens J. H. Petersen Thomas H. Petersen Charlotte Brasch‐Andersen Arne Høst Susanne Halken Grith L. Sorensen Lone Agertoft Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adults Immunity, Inflammation and Disease adolescent asthma biomarker child surfactant protein D |
| title | Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adults |
| title_full | Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adults |
| title_fullStr | Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adults |
| title_full_unstemmed | Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adults |
| title_short | Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adults |
| title_sort | association of serum surfactant protein d and sftpd gene variants with asthma in danish children adolescents and young adults |
| topic | adolescent asthma biomarker child surfactant protein D |
| url | https://doi.org/10.1002/iid3.560 |
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