Ultrasound combined blood‐brain barrier targeting brain delivery of four‐in‐one molecular aggregates for the enhancement of anesthetic efficacy and toxicity reduction via propofol‐etomidate synergistically inhibition GABA receptor

Ultrasound combined blood‐brain barrier targeting brain delivery of four‐in‐one molecular aggregates for the enhancement of anesthetic efficacy and toxicity reduction via propofol‐etomidate synergistically inhibition GABA receptor

Abstract To enhance the anesthetic efficacy and reduce toxic side effects, a strategy is proposed involving the utilization of general anesthetics of Propofol (Pro) and Etomidate (Eto) to synergistic inhibition GABA receptors simultaneously. Four‐in‐one molecular aggregates were prepared to implemen...

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Bibliographic Details
Main Authors: Shuo Zhang, Yishu Wang, Mingting Zhu, Bingyang Liu, Wenpu Zhao, Shuai Zhang, Ji Xia, Lei Shi, Peng Tang, Feiqian Wang, Siyuan Zhang, Mingxi Wan, Daocheng Wu, Wei Gao
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Aggregate
Subjects:
blood‐brain barrier
brain delivery
GABA receptor
molecular aggregates
synergistic anesthetic efficacy
Online Access:https://doi.org/10.1002/agt2.573
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