DEVELOPPEMENT DES COMPRIMES AVEC ACIDE ACETYLSALICILIQUE TAMPONNEES (AAST)
On the Romanian market there are several buffered acetylsalycilic acid tablets (BASAT), made by different producers that use the same acetylsalycilic acid quantity (500 mg/tablet) but use different agents like calcium gluconate (150 mg/tablet) or calcium carbonate (250 mg/tablet). The objective of t...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Alma Mater Publishing House "Vasile Alecsandri" University of Bacau
2010-10-01
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| Series: | Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry |
| Subjects: | |
| Online Access: | http://pubs.ub.ro/dwnl.php?id=CSCC6201011V03S01A0010 |
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| Summary: | On the Romanian market there are several buffered acetylsalycilic acid tablets (BASAT), made by different producers that use the same acetylsalycilic acid quantity (500 mg/tablet) but use different agents like calcium gluconate (150 mg/tablet) or calcium carbonate (250 mg/tablet). The objective of this work is to obtain an optimal formulation for BASAT. Four different BASAT formulations have been obtained by wet granulation followed by compression. These formulations have been submitted to control tests as indicated by Pharmacopoeias. All the four formulations correspond regarding organoleptic examination, mass uniformity, mechanical strength (mean values between 67.6 – 199.4 N), friability (0.1832 – 0.4612% compared to max. 1%), disintegration (33.6 – 76.66 s). The mechanical strength and disintegration for F3 are greater than for F1, F2, and F4. The neutralizing capacity (0.91 – 2.71 mEq HCl that can neutralize 325 mg acetylsalycilic acid) is according to Pharmacopoeia only for F3 and F4 formulations. |
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| ISSN: | 1582-540X |