The role of reactive astrocitose in the chronological evolution of traumatic brain injury
Introduction and objectives. This study aims to investigate whether the cerebral modifications of posttraumatic reactive astrocitose can be considered an objective criterion for determining the age of traumatic cranio-cerebral lesions. Materials and methods. The present study consists of a series...
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MDPI AG
2018-04-01
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| Series: | Journal of Mind and Medical Sciences |
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| Online Access: | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1102&context=jmms |
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| author | Roxana M. Duncea-Borca Vladimir Belis Mihnea Costescu Relu G. Calota Reka Kutasi Cosmin A. Moldovan |
| author_facet | Roxana M. Duncea-Borca Vladimir Belis Mihnea Costescu Relu G. Calota Reka Kutasi Cosmin A. Moldovan |
| author_sort | Roxana M. Duncea-Borca |
| collection | DOAJ |
| description | Introduction and objectives. This study aims to investigate whether the cerebral modifications of posttraumatic reactive astrocitose can be considered an objective criterion for determining the age of traumatic cranio-cerebral lesions.
Materials and methods. The present study consists of a series of 23 medico-legal cases that underwent autopsy inTeleormanCounty(Romania) Department of Forensic Medicine during 2007–2016, with full immune-histochemical microscopic examination using GFAP staining. The study consists of two groups, a series of 13 cases with cranio-cerebral trauma with different posttraumatic survival periods and 9 cases as a control group.
Results and discussions. We discovered GFAP+ reactive astrocytes even when death occurred immediately after the trauma event and up to 4 months after the traumatic incident. We also discovered an intense positive correlation between the density of the GFAP+ cell from the perilesional area and the posttraumatic survival period. The highest cerebral density of the GFAP+ astrocytes occurred with acute death prior (1 to 24 hours) and the lowest in the chronic period (over 2 weeks).
Conclusions. The gradual and differentiated appearance of the reactive astrocytes in close relation with the cerebral posttraumatic interval, with specific lesional and perilesional distribution as well as in surrounding area, clearly demonstrates that the state of the reactive astrocitose may constitute an objective index for evaluation of the elapsed time after the posttraumatic event. |
| format | Article |
| id | doaj-art-2b4b37e3a7894e239f9bffef4c47989e |
| institution | OA Journals |
| issn | 2392-7674 2392-7674 |
| language | English |
| publishDate | 2018-04-01 |
| publisher | MDPI AG |
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| series | Journal of Mind and Medical Sciences |
| spelling | doaj-art-2b4b37e3a7894e239f9bffef4c47989e2025-08-20T02:04:10ZengMDPI AGJournal of Mind and Medical Sciences2392-76742392-76742018-04-015110911610.22543/7674.51.P109116The role of reactive astrocitose in the chronological evolution of traumatic brain injuryRoxana M. Duncea-Borca0Vladimir Belis1Mihnea Costescu2Relu G. Calota3Reka Kutasi4Cosmin A. Moldovan5Forensic Medicine of Teleorman County, Department of Forensic MedicineCarol Davila University of Medicine and Pharmacy, Mina Minovici National Institute of Forensic MedicineCarol Davila University of Medicine and Pharmacy, Mina Minovici National Institute of Forensic MedicineForensic Medicine of Teleorman County, Department of Forensic MedicineTârgu Mureș University of Medicine and Pharmacy, Faculty of MedicineTitu Maiorescu University of Bucharest, Faculty of Medicine, Bucharest, RomaniaIntroduction and objectives. This study aims to investigate whether the cerebral modifications of posttraumatic reactive astrocitose can be considered an objective criterion for determining the age of traumatic cranio-cerebral lesions. Materials and methods. The present study consists of a series of 23 medico-legal cases that underwent autopsy inTeleormanCounty(Romania) Department of Forensic Medicine during 2007–2016, with full immune-histochemical microscopic examination using GFAP staining. The study consists of two groups, a series of 13 cases with cranio-cerebral trauma with different posttraumatic survival periods and 9 cases as a control group. Results and discussions. We discovered GFAP+ reactive astrocytes even when death occurred immediately after the trauma event and up to 4 months after the traumatic incident. We also discovered an intense positive correlation between the density of the GFAP+ cell from the perilesional area and the posttraumatic survival period. The highest cerebral density of the GFAP+ astrocytes occurred with acute death prior (1 to 24 hours) and the lowest in the chronic period (over 2 weeks). Conclusions. The gradual and differentiated appearance of the reactive astrocytes in close relation with the cerebral posttraumatic interval, with specific lesional and perilesional distribution as well as in surrounding area, clearly demonstrates that the state of the reactive astrocitose may constitute an objective index for evaluation of the elapsed time after the posttraumatic event.https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1102&context=jmmsreactive astrocytesGFAPcranio-cerebral traumadeath period |
| spellingShingle | Roxana M. Duncea-Borca Vladimir Belis Mihnea Costescu Relu G. Calota Reka Kutasi Cosmin A. Moldovan The role of reactive astrocitose in the chronological evolution of traumatic brain injury Journal of Mind and Medical Sciences reactive astrocytes GFAP cranio-cerebral trauma death period |
| title | The role of reactive astrocitose in the chronological evolution of traumatic brain injury |
| title_full | The role of reactive astrocitose in the chronological evolution of traumatic brain injury |
| title_fullStr | The role of reactive astrocitose in the chronological evolution of traumatic brain injury |
| title_full_unstemmed | The role of reactive astrocitose in the chronological evolution of traumatic brain injury |
| title_short | The role of reactive astrocitose in the chronological evolution of traumatic brain injury |
| title_sort | role of reactive astrocitose in the chronological evolution of traumatic brain injury |
| topic | reactive astrocytes GFAP cranio-cerebral trauma death period |
| url | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1102&context=jmms |
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