Terbinafine-induced generalized pustular psoriasis treated with dapsone
We report the case of a 37-year-old healthy woman who developed a generalized cutaneous eruption 1 week after starting oral terbinafine. The eruption was nonspecific, composed of erythematous—violaceous patches, limited areas of epidermal detachment, and sparse sterile pustules. Initial differential...
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Sociedade Portuguesa de Dermatologia e Venereologia
2025-04-01
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| Series: | Revista da Sociedade Portuguesa de Dermatologia e Venereologia |
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| Online Access: | https://www.portuguesejournalofdermatology.com/frame_eng.php?id=216 |
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| author | Matilde Monteiro Joana F. Matos André Coelho Catarina Queirós |
| author_facet | Matilde Monteiro Joana F. Matos André Coelho Catarina Queirós |
| author_sort | Matilde Monteiro |
| collection | DOAJ |
| description | We report the case of a 37-year-old healthy woman who developed a generalized cutaneous eruption 1 week after starting oral terbinafine. The eruption was nonspecific, composed of erythematous—violaceous patches, limited areas of epidermal detachment, and sparse sterile pustules. Initial differential diagnoses included Stevens—Johnson Syndrome (SJS) and Acute Generalized Exanthematous Pustulosis (AGEP). Systemic corticosteroid therapy was initiated, with no improvement after 2 weeks. Skin biopsies suggested a diagnosis of pustular psoriasis,and during hospitalization, the patient developed scalyplaques on her scalp, more in keeping with terbinafine-induced Generalized Pustular Psoriasis (GPP). The patient was started on cyclosporine, which proved ineffective, followed by oral dapsone, which led toa major improvement within just 2 days. This case highlights the difficulty of differentiating between SJS, AGEP, and GPP in the presence of a nonspecific drug eruption and suggests dapsone as a safe therapeutic alternative for GPP.
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| format | Article |
| id | doaj-art-2b48444307d242abb9df227803cd70fa |
| institution | Kabale University |
| issn | 2182-2395 2182-2409 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Sociedade Portuguesa de Dermatologia e Venereologia |
| record_format | Article |
| series | Revista da Sociedade Portuguesa de Dermatologia e Venereologia |
| spelling | doaj-art-2b48444307d242abb9df227803cd70fa2025-08-20T03:30:41ZengSociedade Portuguesa de Dermatologia e VenereologiaRevista da Sociedade Portuguesa de Dermatologia e Venereologia2182-23952182-24092025-04-01832Terbinafine-induced generalized pustular psoriasis treated with dapsoneMatilde Monteiro0Joana F. Matos1André Coelho2Catarina Queirós3Department of Dermatology, Unidade Local de Saúde de Gaia/Espinho, EPE, Porto, PortugalDepartment of Dermatology, Unidade Local de Saúde de Gaia/Espinho, EPE, Porto, PortugalDepartment of Pathological Anatomy. Centro Hospitalar Universitário de Santo António, Porto, PortugalServiço de Dermatologia, Hospital de Santa Maria, Centro Hospitalar e Universitário de Lisboa Norte, Lisbon, PortugalWe report the case of a 37-year-old healthy woman who developed a generalized cutaneous eruption 1 week after starting oral terbinafine. The eruption was nonspecific, composed of erythematous—violaceous patches, limited areas of epidermal detachment, and sparse sterile pustules. Initial differential diagnoses included Stevens—Johnson Syndrome (SJS) and Acute Generalized Exanthematous Pustulosis (AGEP). Systemic corticosteroid therapy was initiated, with no improvement after 2 weeks. Skin biopsies suggested a diagnosis of pustular psoriasis,and during hospitalization, the patient developed scalyplaques on her scalp, more in keeping with terbinafine-induced Generalized Pustular Psoriasis (GPP). The patient was started on cyclosporine, which proved ineffective, followed by oral dapsone, which led toa major improvement within just 2 days. This case highlights the difficulty of differentiating between SJS, AGEP, and GPP in the presence of a nonspecific drug eruption and suggests dapsone as a safe therapeutic alternative for GPP. https://www.portuguesejournalofdermatology.com/frame_eng.php?id=216Generalized pustular psoriasis. Drug eruption. Terbinafine. Dapsone. |
| spellingShingle | Matilde Monteiro Joana F. Matos André Coelho Catarina Queirós Terbinafine-induced generalized pustular psoriasis treated with dapsone Revista da Sociedade Portuguesa de Dermatologia e Venereologia Generalized pustular psoriasis. Drug eruption. Terbinafine. Dapsone. |
| title | Terbinafine-induced generalized pustular psoriasis treated with dapsone |
| title_full | Terbinafine-induced generalized pustular psoriasis treated with dapsone |
| title_fullStr | Terbinafine-induced generalized pustular psoriasis treated with dapsone |
| title_full_unstemmed | Terbinafine-induced generalized pustular psoriasis treated with dapsone |
| title_short | Terbinafine-induced generalized pustular psoriasis treated with dapsone |
| title_sort | terbinafine induced generalized pustular psoriasis treated with dapsone |
| topic | Generalized pustular psoriasis. Drug eruption. Terbinafine. Dapsone. |
| url | https://www.portuguesejournalofdermatology.com/frame_eng.php?id=216 |
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