Longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults: healthy aging in neighborhoods of diversity across the life span study
Abstract Longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults remain under-studied, especially across sex, race and levels of anxiety. We examined longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults, before...
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Nature Publishing Group
2024-10-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-024-03111-7 |
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| author | Michael F. Georgescu May A. Beydoun Christian A. Maino Vieytes Marie T. Fanelli-Kuczmarski Jason Ashe Hind A. Beydoun Sharmin Hossain Nicole Noren Hooten Michele K. Evans Alan B. Zonderman |
| author_facet | Michael F. Georgescu May A. Beydoun Christian A. Maino Vieytes Marie T. Fanelli-Kuczmarski Jason Ashe Hind A. Beydoun Sharmin Hossain Nicole Noren Hooten Michele K. Evans Alan B. Zonderman |
| author_sort | Michael F. Georgescu |
| collection | DOAJ |
| description | Abstract Longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults remain under-studied, especially across sex, race and levels of anxiety. We examined longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults, before and after stratifying by sex, race and anxiety level, using data from 1460 Healthy Aging in Neighborhoods of Diversity across the Lifespan Study (HANDLS) participants aged 30–64 y at v1 (2004–2009), followed across 3 visits up to 2017. In addition to LnHcyv1, we used group-based trajectory models predicting z-transformed likelihood of greater LnHcy with age (Hcytraj). Total and domain-specific depression symptoms were scored using Center for Epidemiologic Studies Depression (CES-D) scale. Mixed-effects linear regression models and Cox proportional hazards models were utilized. A positive association was found between baseline LnHcyv1 and CES-D total scores in reduced socio-demographic- adjusted Model 1 (β (standard error [SE]) = + 2.337 (0.902), P = 0.010), a relationship slightly attenuated in fully adjusted Model 2 (Model 1 adjusting for lifestyle and health factors) with a β (SE) = + 1.825 (0.883), P = 0.039. Individuals with lower anxiety levels experienced faster CES-D domain 2 score annualized increase over time (interpersonal problems) with higher LnHcyv1 (β (SE) = 0.041 (0.018), P = 0.024). Hcytraj was linked to incident elevated depressive symptoms (CES-D total score ≥16) overall (fully adjusted model: HR = 1.09, 95% CI: 1.03–1.14, P = 0.001), particularly among women and those living in poverty. Baseline and “high trajectory” of LnHcy were positively associated with depressive symptoms and elevated depressive symptom incidence, in a sex-, race-, poverty status- and anxiety-level specific manner. |
| format | Article |
| id | doaj-art-2b40f7ee6da644c4ad6d64658d431e4e |
| institution | OA Journals |
| issn | 2158-3188 |
| language | English |
| publishDate | 2024-10-01 |
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| series | Translational Psychiatry |
| spelling | doaj-art-2b40f7ee6da644c4ad6d64658d431e4e2025-08-20T02:17:52ZengNature Publishing GroupTranslational Psychiatry2158-31882024-10-0114111610.1038/s41398-024-03111-7Longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults: healthy aging in neighborhoods of diversity across the life span studyMichael F. Georgescu0May A. Beydoun1Christian A. Maino Vieytes2Marie T. Fanelli-Kuczmarski3Jason Ashe4Hind A. Beydoun5Sharmin Hossain6Nicole Noren Hooten7Michele K. Evans8Alan B. Zonderman9Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research ProgramLaboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research ProgramLaboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research ProgramLaboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research ProgramLaboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research ProgramVA National Center on Homelessness Among Veterans, U.S. Department of Veterans AffairsDepartment of Human Services, State of MarylandLaboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research ProgramLaboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research ProgramLaboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research ProgramAbstract Longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults remain under-studied, especially across sex, race and levels of anxiety. We examined longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults, before and after stratifying by sex, race and anxiety level, using data from 1460 Healthy Aging in Neighborhoods of Diversity across the Lifespan Study (HANDLS) participants aged 30–64 y at v1 (2004–2009), followed across 3 visits up to 2017. In addition to LnHcyv1, we used group-based trajectory models predicting z-transformed likelihood of greater LnHcy with age (Hcytraj). Total and domain-specific depression symptoms were scored using Center for Epidemiologic Studies Depression (CES-D) scale. Mixed-effects linear regression models and Cox proportional hazards models were utilized. A positive association was found between baseline LnHcyv1 and CES-D total scores in reduced socio-demographic- adjusted Model 1 (β (standard error [SE]) = + 2.337 (0.902), P = 0.010), a relationship slightly attenuated in fully adjusted Model 2 (Model 1 adjusting for lifestyle and health factors) with a β (SE) = + 1.825 (0.883), P = 0.039. Individuals with lower anxiety levels experienced faster CES-D domain 2 score annualized increase over time (interpersonal problems) with higher LnHcyv1 (β (SE) = 0.041 (0.018), P = 0.024). Hcytraj was linked to incident elevated depressive symptoms (CES-D total score ≥16) overall (fully adjusted model: HR = 1.09, 95% CI: 1.03–1.14, P = 0.001), particularly among women and those living in poverty. Baseline and “high trajectory” of LnHcy were positively associated with depressive symptoms and elevated depressive symptom incidence, in a sex-, race-, poverty status- and anxiety-level specific manner.https://doi.org/10.1038/s41398-024-03111-7 |
| spellingShingle | Michael F. Georgescu May A. Beydoun Christian A. Maino Vieytes Marie T. Fanelli-Kuczmarski Jason Ashe Hind A. Beydoun Sharmin Hossain Nicole Noren Hooten Michele K. Evans Alan B. Zonderman Longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults: healthy aging in neighborhoods of diversity across the life span study Translational Psychiatry |
| title | Longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults: healthy aging in neighborhoods of diversity across the life span study |
| title_full | Longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults: healthy aging in neighborhoods of diversity across the life span study |
| title_fullStr | Longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults: healthy aging in neighborhoods of diversity across the life span study |
| title_full_unstemmed | Longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults: healthy aging in neighborhoods of diversity across the life span study |
| title_short | Longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults: healthy aging in neighborhoods of diversity across the life span study |
| title_sort | longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults healthy aging in neighborhoods of diversity across the life span study |
| url | https://doi.org/10.1038/s41398-024-03111-7 |
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