<i>EPAS1</i> Variations and Hematological Adaptations to High-Altitude Hypoxia in Indigenous Goats in Yunnan Province, China
The <i>EPAS1</i> gene plays a central role in hypoxia adaptation in high-altitude animals. Using over 400 blood samples from goats across elevations in Yunnan (500–3500 m), this study examined hematological traits, genetic polymorphisms, and protein structure. Red blood cell (RBC) and he...
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MDPI AG
2025-02-01
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| author | Li Zhu Lin Tang Yunong Zhao Shanshan Li Xiao Gou Weidong Deng Xiaoyan Kong |
| author_facet | Li Zhu Lin Tang Yunong Zhao Shanshan Li Xiao Gou Weidong Deng Xiaoyan Kong |
| author_sort | Li Zhu |
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| description | The <i>EPAS1</i> gene plays a central role in hypoxia adaptation in high-altitude animals. Using over 400 blood samples from goats across elevations in Yunnan (500–3500 m), this study examined hematological traits, genetic polymorphisms, and protein structure. Red blood cell (RBC) and hemoglobin (HGB) levels increased significantly with altitude (<i>p</i> < 0.05), reflecting improved oxygen transport. A non-synonymous SNP (<i>g.86650 A>T</i>, p.Gln556Leu) exhibited adaptive selection, with the <i>T</i> allele frequency rising at higher altitudes (<i>p</i> < 0.05). At 2500 m, <i>TT</i> genotype goats showed significantly higher RBC and HGB levels than AA genotypes (<i>p</i> < 0.05). Protein modeling revealed structural instability caused by the polymorphism, highlighting its role in enhancing hypoxia adaptation. These findings provide a foundation for improving high-altitude livestock genetics. |
| format | Article |
| id | doaj-art-2b3dfcd23bbc4886b60d2dad3f434460 |
| institution | DOAJ |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| series | Animals |
| spelling | doaj-art-2b3dfcd23bbc4886b60d2dad3f4344602025-08-20T02:52:35ZengMDPI AGAnimals2076-26152025-02-0115569510.3390/ani15050695<i>EPAS1</i> Variations and Hematological Adaptations to High-Altitude Hypoxia in Indigenous Goats in Yunnan Province, ChinaLi Zhu0Lin Tang1Yunong Zhao2Shanshan Li3Xiao Gou4Weidong Deng5Xiaoyan Kong6Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, ChinaFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, ChinaSchool of Animal Science and Technology, Foshan University, Foshan 528231, ChinaSchool of Animal Science and Technology, Foshan University, Foshan 528231, ChinaSchool of Animal Science and Technology, Foshan University, Foshan 528231, ChinaFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, ChinaFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, ChinaThe <i>EPAS1</i> gene plays a central role in hypoxia adaptation in high-altitude animals. Using over 400 blood samples from goats across elevations in Yunnan (500–3500 m), this study examined hematological traits, genetic polymorphisms, and protein structure. Red blood cell (RBC) and hemoglobin (HGB) levels increased significantly with altitude (<i>p</i> < 0.05), reflecting improved oxygen transport. A non-synonymous SNP (<i>g.86650 A>T</i>, p.Gln556Leu) exhibited adaptive selection, with the <i>T</i> allele frequency rising at higher altitudes (<i>p</i> < 0.05). At 2500 m, <i>TT</i> genotype goats showed significantly higher RBC and HGB levels than AA genotypes (<i>p</i> < 0.05). Protein modeling revealed structural instability caused by the polymorphism, highlighting its role in enhancing hypoxia adaptation. These findings provide a foundation for improving high-altitude livestock genetics.https://www.mdpi.com/2076-2615/15/5/695Tibetan goat<i>EPAS1</i> genegenetic polymorphismhematological traitshypoxia adaptation |
| spellingShingle | Li Zhu Lin Tang Yunong Zhao Shanshan Li Xiao Gou Weidong Deng Xiaoyan Kong <i>EPAS1</i> Variations and Hematological Adaptations to High-Altitude Hypoxia in Indigenous Goats in Yunnan Province, China Animals Tibetan goat <i>EPAS1</i> gene genetic polymorphism hematological traits hypoxia adaptation |
| title | <i>EPAS1</i> Variations and Hematological Adaptations to High-Altitude Hypoxia in Indigenous Goats in Yunnan Province, China |
| title_full | <i>EPAS1</i> Variations and Hematological Adaptations to High-Altitude Hypoxia in Indigenous Goats in Yunnan Province, China |
| title_fullStr | <i>EPAS1</i> Variations and Hematological Adaptations to High-Altitude Hypoxia in Indigenous Goats in Yunnan Province, China |
| title_full_unstemmed | <i>EPAS1</i> Variations and Hematological Adaptations to High-Altitude Hypoxia in Indigenous Goats in Yunnan Province, China |
| title_short | <i>EPAS1</i> Variations and Hematological Adaptations to High-Altitude Hypoxia in Indigenous Goats in Yunnan Province, China |
| title_sort | i epas1 i variations and hematological adaptations to high altitude hypoxia in indigenous goats in yunnan province china |
| topic | Tibetan goat <i>EPAS1</i> gene genetic polymorphism hematological traits hypoxia adaptation |
| url | https://www.mdpi.com/2076-2615/15/5/695 |
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