Correlation study of CAR, PLR, NLR with the prognosis of cardiogenic cerebral embolism patients
This study explored the association between inflammatory biomarkers—C-reactive protein to albumin ratio (CAR), platelet to lymphocyte ratio (PLR), and neutrophil to lymphocyte ratio (NLR)—and the prognosis of patients with cardiogenic cerebral embolism (CCE). We retrospectively analyzed data from 80...
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Frontiers Media S.A.
2025-06-01
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| Series: | Experimental Biology and Medicine |
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| Online Access: | https://www.ebm-journal.org/articles/10.3389/ebm.2025.10517/full |
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| author | Xiaojing Du Xiaohui Li Sheng Yue Yuzhen Sun Mengzhen Zhao Lingshan Zhou Xingwei Wang Yapan Yang |
| author_facet | Xiaojing Du Xiaohui Li Sheng Yue Yuzhen Sun Mengzhen Zhao Lingshan Zhou Xingwei Wang Yapan Yang |
| author_sort | Xiaojing Du |
| collection | DOAJ |
| description | This study explored the association between inflammatory biomarkers—C-reactive protein to albumin ratio (CAR), platelet to lymphocyte ratio (PLR), and neutrophil to lymphocyte ratio (NLR)—and the prognosis of patients with cardiogenic cerebral embolism (CCE). We retrospectively analyzed data from 80 CCE patients diagnosed between June 2020 and June 2024, categorizing them into favorable and unfavorable prognosis groups based on outcomes such as death, recurrence, and disability. The CAR, PLR, and NLR values were calculated from routine blood tests, and statistical analyses, including Spearman correlation, multivariate logistic regression, and ROC curve analysis, were performed to examine their prognostic significance. Results showed that the unfavorable prognosis group had significantly higher CAR, PLR, and NLR values compared to the favorable group (P < 0.05). Spearman correlation analysis revealed positive associations between these biomarkers and prognosis (r = 0.319 for CAR, 0.238 for PLR, 0.251 for NLR, all P < 0.05). Multivariate analysis identified CAR and NLR as independent risk factors for unfavorable prognosis (OR = 1.034 for CAR, OR = 3.887 for NLR). ROC analysis determined optimal cutoff values for CAR (>0.74), PLR (>160.00), and NLR (>3.53) to predict unfavorable prognosis with AUCs of 0.796, 0.694, and 0.705, respectively. The combined biomarker test yielded an AUC of 0.899. Kaplan-Meier survival analysis indicated significantly lower survival rates for patients with higher levels of CAR, PLR, and NLR (P < 0.05). In conclusion, elevated CAR, PLR, and NLR are reliable indicators of a poor prognosis in CCE patients. |
| format | Article |
| id | doaj-art-2b3db642b69a4d848d3afb06ed7b8950 |
| institution | DOAJ |
| issn | 1535-3699 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Experimental Biology and Medicine |
| spelling | doaj-art-2b3db642b69a4d848d3afb06ed7b89502025-08-20T03:21:26ZengFrontiers Media S.A.Experimental Biology and Medicine1535-36992025-06-0125010.3389/ebm.2025.1051710517Correlation study of CAR, PLR, NLR with the prognosis of cardiogenic cerebral embolism patientsXiaojing Du0Xiaohui Li1Sheng Yue2Yuzhen Sun3Mengzhen Zhao4Lingshan Zhou5Xingwei Wang6Yapan Yang7Department of Comprehensive Intensive Care Unit, Central China Fuwai Hospital, Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Heart Center of Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Comprehensive Intensive Care Unit, Central China Fuwai Hospital, Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Heart Center of Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Comprehensive Intensive Care Unit, Central China Fuwai Hospital, Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Heart Center of Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Comprehensive Intensive Care Unit, Central China Fuwai Hospital, Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Heart Center of Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Comprehensive Intensive Care Unit, Central China Fuwai Hospital, Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Heart Center of Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Comprehensive Intensive Care Unit, Central China Fuwai Hospital, Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Heart Center of Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Comprehensive Intensive Care Unit, Central China Fuwai Hospital, Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Heart Center of Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Cardiology, Central China Fuwai Hospital, Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Heart Center of Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaThis study explored the association between inflammatory biomarkers—C-reactive protein to albumin ratio (CAR), platelet to lymphocyte ratio (PLR), and neutrophil to lymphocyte ratio (NLR)—and the prognosis of patients with cardiogenic cerebral embolism (CCE). We retrospectively analyzed data from 80 CCE patients diagnosed between June 2020 and June 2024, categorizing them into favorable and unfavorable prognosis groups based on outcomes such as death, recurrence, and disability. The CAR, PLR, and NLR values were calculated from routine blood tests, and statistical analyses, including Spearman correlation, multivariate logistic regression, and ROC curve analysis, were performed to examine their prognostic significance. Results showed that the unfavorable prognosis group had significantly higher CAR, PLR, and NLR values compared to the favorable group (P < 0.05). Spearman correlation analysis revealed positive associations between these biomarkers and prognosis (r = 0.319 for CAR, 0.238 for PLR, 0.251 for NLR, all P < 0.05). Multivariate analysis identified CAR and NLR as independent risk factors for unfavorable prognosis (OR = 1.034 for CAR, OR = 3.887 for NLR). ROC analysis determined optimal cutoff values for CAR (>0.74), PLR (>160.00), and NLR (>3.53) to predict unfavorable prognosis with AUCs of 0.796, 0.694, and 0.705, respectively. The combined biomarker test yielded an AUC of 0.899. Kaplan-Meier survival analysis indicated significantly lower survival rates for patients with higher levels of CAR, PLR, and NLR (P < 0.05). In conclusion, elevated CAR, PLR, and NLR are reliable indicators of a poor prognosis in CCE patients.https://www.ebm-journal.org/articles/10.3389/ebm.2025.10517/fullcardiogenic cerebral embolismprognosisCARPLRNLR |
| spellingShingle | Xiaojing Du Xiaohui Li Sheng Yue Yuzhen Sun Mengzhen Zhao Lingshan Zhou Xingwei Wang Yapan Yang Correlation study of CAR, PLR, NLR with the prognosis of cardiogenic cerebral embolism patients Experimental Biology and Medicine cardiogenic cerebral embolism prognosis CAR PLR NLR |
| title | Correlation study of CAR, PLR, NLR with the prognosis of cardiogenic cerebral embolism patients |
| title_full | Correlation study of CAR, PLR, NLR with the prognosis of cardiogenic cerebral embolism patients |
| title_fullStr | Correlation study of CAR, PLR, NLR with the prognosis of cardiogenic cerebral embolism patients |
| title_full_unstemmed | Correlation study of CAR, PLR, NLR with the prognosis of cardiogenic cerebral embolism patients |
| title_short | Correlation study of CAR, PLR, NLR with the prognosis of cardiogenic cerebral embolism patients |
| title_sort | correlation study of car plr nlr with the prognosis of cardiogenic cerebral embolism patients |
| topic | cardiogenic cerebral embolism prognosis CAR PLR NLR |
| url | https://www.ebm-journal.org/articles/10.3389/ebm.2025.10517/full |
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