A comprehensive characterization of metabolic signatures—hypoxia, glycolysis, and lactylation—in non-healing diabetic foot ulcers

A comprehensive characterization of metabolic signatures—hypoxia, glycolysis, and lactylation—in non-healing diabetic foot ulcers

Background and ObjectiveDiabetic foot ulcers (DFUs) are chronic complications of diabetes, driven by metabolic dysregulation and impaired wound healing. This study investigates the roles of hypoxia, glycolysis, and lactylation in DFUs and identifies potential diagnostic and therapeutic biomarkers.Me...

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Bibliographic Details
Main Authors: Bo Hu, Xuan Li, Yunfeng Li, Shengnan Chai, Mei Jin, Long Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
diabetic foot ulcers
metabolic reprogramming
hypoxia
glycolysis
lactylation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1593390/full
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