Evaluating the impact of Matrilin-1 gene polymorphisms on mandibular prognathism: A meta-analysis
Introduction: Matrilin-1 was shown to regulate the formation of cartilage matrix and to promote chondrocyte differentiation. This meta-analysis aims to synthesize evidence regarding the link between mandibular prognathism (MP) risk and the polymorphisms in the MATN1 gene. Materials and methods: Rele...
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Elsevier
2025-07-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221242682500082X |
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| author | Pooja Kurmi Prasad Nalabothu Shubhasmita Sahoo Henu Kumar Verma Srinivas Gosla Reddy L.V.K.S. Bhaskar |
| author_facet | Pooja Kurmi Prasad Nalabothu Shubhasmita Sahoo Henu Kumar Verma Srinivas Gosla Reddy L.V.K.S. Bhaskar |
| author_sort | Pooja Kurmi |
| collection | DOAJ |
| description | Introduction: Matrilin-1 was shown to regulate the formation of cartilage matrix and to promote chondrocyte differentiation. This meta-analysis aims to synthesize evidence regarding the link between mandibular prognathism (MP) risk and the polymorphisms in the MATN1 gene. Materials and methods: Relevant publications were retrieved by searching the PubMed, Web of Science, and Google Scholar databases. The association between MP and the MATN1 gene polymorphisms (rs20566, rs1065755) was assessed by calculating odds ratios (ORs) and 95 % CIs. Between studies, heterogeneity was identified using the Cochrane Q test and I2 statistics. To assess the robustness of the meta-analysis sensitivity analysis was performed. The web tool MetaGenyo was used to conduct a meta-analysis. Results: A total of four Asian and one Caucasian study were eventually taken for meta-analysis. Overall, the MATN1 rs20566 and rs1065755 polymorphisms are not associated with elevated risk of MP (rs20566 AA + AG versus GG OR = 1.35, 95 % CI = 0.32–5.67; rs1065755 TT + CT versus CC OR = 2.02, 95 % CI = 0.87–4.68). The degree of heterogeneity is found to be large for the MATN1 polymorphisms (for rs20566, I2=89 %, and for rs1065755, I2=60 %). Conclusions: In conclusion, this meta-analysis did not provide evidence for the link between MATN1 polymorphisms and MP. However, the results conflict with the biological plausibility that matrilin-1 levels modulate cartilage development. Therefore, careful interpretation is needed, and further research is recommended. |
| format | Article |
| id | doaj-art-2b3c5df2b8a342ba9a4d427245fa7971 |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
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| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-2b3c5df2b8a342ba9a4d427245fa79712025-08-20T03:43:54ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682025-07-0115469169510.1016/j.jobcr.2025.03.019Evaluating the impact of Matrilin-1 gene polymorphisms on mandibular prognathism: A meta-analysisPooja Kurmi0Prasad Nalabothu1Shubhasmita Sahoo2Henu Kumar Verma3Srinivas Gosla Reddy4L.V.K.S. Bhaskar5Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, IndiaDepartment of Paediatric Oral Health and Orthodontics, University Center for Dental Medicine Basel UZB, Basel, Switzerland; Corresponding author. Oral and Craniomaxillofacial Surgery, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, IndiaDepartment of Immunopathology, Institute of Lungs Biology and Disease, Comprehensive Pneumology Center, Helmholtz Zentrum, Neuherberg, 85764, Munich, GermanyGSR Institute of Cranio-Maxillofacial and Facial Plastic Surgery, Hyderabad, Telangana, IndiaDepartment of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India; Corresponding author.Introduction: Matrilin-1 was shown to regulate the formation of cartilage matrix and to promote chondrocyte differentiation. This meta-analysis aims to synthesize evidence regarding the link between mandibular prognathism (MP) risk and the polymorphisms in the MATN1 gene. Materials and methods: Relevant publications were retrieved by searching the PubMed, Web of Science, and Google Scholar databases. The association between MP and the MATN1 gene polymorphisms (rs20566, rs1065755) was assessed by calculating odds ratios (ORs) and 95 % CIs. Between studies, heterogeneity was identified using the Cochrane Q test and I2 statistics. To assess the robustness of the meta-analysis sensitivity analysis was performed. The web tool MetaGenyo was used to conduct a meta-analysis. Results: A total of four Asian and one Caucasian study were eventually taken for meta-analysis. Overall, the MATN1 rs20566 and rs1065755 polymorphisms are not associated with elevated risk of MP (rs20566 AA + AG versus GG OR = 1.35, 95 % CI = 0.32–5.67; rs1065755 TT + CT versus CC OR = 2.02, 95 % CI = 0.87–4.68). The degree of heterogeneity is found to be large for the MATN1 polymorphisms (for rs20566, I2=89 %, and for rs1065755, I2=60 %). Conclusions: In conclusion, this meta-analysis did not provide evidence for the link between MATN1 polymorphisms and MP. However, the results conflict with the biological plausibility that matrilin-1 levels modulate cartilage development. Therefore, careful interpretation is needed, and further research is recommended.http://www.sciencedirect.com/science/article/pii/S221242682500082XMandibular prognathismMatrilinMATN1rs20566rs1065755Meta-analysis |
| spellingShingle | Pooja Kurmi Prasad Nalabothu Shubhasmita Sahoo Henu Kumar Verma Srinivas Gosla Reddy L.V.K.S. Bhaskar Evaluating the impact of Matrilin-1 gene polymorphisms on mandibular prognathism: A meta-analysis Journal of Oral Biology and Craniofacial Research Mandibular prognathism Matrilin MATN1 rs20566 rs1065755 Meta-analysis |
| title | Evaluating the impact of Matrilin-1 gene polymorphisms on mandibular prognathism: A meta-analysis |
| title_full | Evaluating the impact of Matrilin-1 gene polymorphisms on mandibular prognathism: A meta-analysis |
| title_fullStr | Evaluating the impact of Matrilin-1 gene polymorphisms on mandibular prognathism: A meta-analysis |
| title_full_unstemmed | Evaluating the impact of Matrilin-1 gene polymorphisms on mandibular prognathism: A meta-analysis |
| title_short | Evaluating the impact of Matrilin-1 gene polymorphisms on mandibular prognathism: A meta-analysis |
| title_sort | evaluating the impact of matrilin 1 gene polymorphisms on mandibular prognathism a meta analysis |
| topic | Mandibular prognathism Matrilin MATN1 rs20566 rs1065755 Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S221242682500082X |
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