Association Between Coronary Calcium Detection on Chest Computed Tomography and Ischemic Cardiovascular Events and Mortality in Asymptomatic Chronic Obstructive Pulmonary Disease Patients. Systematic Review of the Literature
Introduction: Literature suggests that there is a close relationship between chronic obstructive pulmonary disease (COPD) and cardiovascular (CV) disease. The aim of this study was to assess whether the presence of coronary calcium (CC) on chest computed tomography (CT) in asymptomatic COPD patients...
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Elsevier
2024-10-01
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| Series: | Open Respiratory Archives |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2659663624000791 |
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| author | Miguel Jiménez-Gómez Juan P. de-Torres-Tajes |
| author_facet | Miguel Jiménez-Gómez Juan P. de-Torres-Tajes |
| author_sort | Miguel Jiménez-Gómez |
| collection | DOAJ |
| description | Introduction: Literature suggests that there is a close relationship between chronic obstructive pulmonary disease (COPD) and cardiovascular (CV) disease. The aim of this study was to assess whether the presence of coronary calcium (CC) on chest computed tomography (CT) in asymptomatic COPD patients is associated with an increased risk of CV events and mortality. Material and methods: A systematic review of the literature was performed following PRISMA recommendations. Studies published in the last 20 years in four databases (PubMed, Web of Science, Embase and MEDLINE) were included. Results: Three hundred fifty articles were identified, eight of them met the selection criteria. The included studies, conducted between 2013 and 2024, were predominantly multicentre cohort studies. The meta-analysis showed that the presence of CC on chest CT of COPD patients is an independent predictor of CV events (hazard ratio 1.44, 95% CI 1.22–1.70) and associated with an increased mortality during the follow-up period (hazard ratio 1.57, 95% CI 1.35–1.83). Conclusions: Our analysis suggests that the identification of CC on chest CT scans of COPD patients may be useful in the early detection and treatment of CV disease in asymptomatic patients. Prospective, multicentre studies confirming our findings are needed to explore the potential impact of early detection and treatment of CV risk in COPD patients. Resumen: Introducción: La literatura sugiere que existe una estrecha relación entre la enfermedad pulmonar obstructiva crónica (EPOC) y la enfermedad cardiovascular (CV). El objetivo de este estudio fue evaluar si la presencia de calcio coronario (CC) en la tomografía computarizada (TC) torácica en pacientes asintomáticos con EPOC se asocia con un mayor riesgo de eventos CV y mortalidad CV. Material y métodos: Se realizó una revisión sistemática de la literatura siguiendo las recomendaciones PRISMA. Se incluyeron estudios publicados en los últimos 20 años en cuatro bases de datos (PubMed, Web of Science, Embase y MEDLINE). Resultados: Se identificaron 350 artículos, ocho de los cuales cumplieron los criterios de inclusión. Los estudios fueron realizados entre 2013 y 2024, con un diseño de cohortes y de carácter multicéntricos. El metaanálisis concluyó que la presencia de CC en la TC torácica de pacientes con EPOC es un predictor independiente de eventos CV (hazard ratio: 1,44; IC 95%: 1,22-1,70), y se relacionó con un aumento de la mortalidad CV en el período de seguimiento (hazard ratio: 1,57; IC 95%: 1,35-1,83). Conclusiones: El análisis sugiere que la identificación de CC en las TC torácicas de pacientes con EPOC puede ser útil en la detección precoz y en el tratamiento de la enfermedad CV en pacientes asintomáticos. Se necesitan estudios prospectivos multicéntricos que confirmen nuestros hallazgos para explorar el impacto potencial de la detección precoz y el tratamiento del riesgo CV en pacientes con EPOC. |
| format | Article |
| id | doaj-art-2b366b0bf9044cecb562c2f4618189fb |
| institution | OA Journals |
| issn | 2659-6636 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Open Respiratory Archives |
| spelling | doaj-art-2b366b0bf9044cecb562c2f4618189fb2025-08-20T02:38:18ZengElsevierOpen Respiratory Archives2659-66362024-10-016410035710.1016/j.opresp.2024.100357Association Between Coronary Calcium Detection on Chest Computed Tomography and Ischemic Cardiovascular Events and Mortality in Asymptomatic Chronic Obstructive Pulmonary Disease Patients. Systematic Review of the LiteratureMiguel Jiménez-Gómez0Juan P. de-Torres-Tajes1Pulmonology Department, 12th of October University Hospital, Madrid, Spain; Corresponding author.Pulmonology Department, Clínica Universidad de Navarra, Pamplona, Navarra, SpainIntroduction: Literature suggests that there is a close relationship between chronic obstructive pulmonary disease (COPD) and cardiovascular (CV) disease. The aim of this study was to assess whether the presence of coronary calcium (CC) on chest computed tomography (CT) in asymptomatic COPD patients is associated with an increased risk of CV events and mortality. Material and methods: A systematic review of the literature was performed following PRISMA recommendations. Studies published in the last 20 years in four databases (PubMed, Web of Science, Embase and MEDLINE) were included. Results: Three hundred fifty articles were identified, eight of them met the selection criteria. The included studies, conducted between 2013 and 2024, were predominantly multicentre cohort studies. The meta-analysis showed that the presence of CC on chest CT of COPD patients is an independent predictor of CV events (hazard ratio 1.44, 95% CI 1.22–1.70) and associated with an increased mortality during the follow-up period (hazard ratio 1.57, 95% CI 1.35–1.83). Conclusions: Our analysis suggests that the identification of CC on chest CT scans of COPD patients may be useful in the early detection and treatment of CV disease in asymptomatic patients. Prospective, multicentre studies confirming our findings are needed to explore the potential impact of early detection and treatment of CV risk in COPD patients. Resumen: Introducción: La literatura sugiere que existe una estrecha relación entre la enfermedad pulmonar obstructiva crónica (EPOC) y la enfermedad cardiovascular (CV). El objetivo de este estudio fue evaluar si la presencia de calcio coronario (CC) en la tomografía computarizada (TC) torácica en pacientes asintomáticos con EPOC se asocia con un mayor riesgo de eventos CV y mortalidad CV. Material y métodos: Se realizó una revisión sistemática de la literatura siguiendo las recomendaciones PRISMA. Se incluyeron estudios publicados en los últimos 20 años en cuatro bases de datos (PubMed, Web of Science, Embase y MEDLINE). Resultados: Se identificaron 350 artículos, ocho de los cuales cumplieron los criterios de inclusión. Los estudios fueron realizados entre 2013 y 2024, con un diseño de cohortes y de carácter multicéntricos. El metaanálisis concluyó que la presencia de CC en la TC torácica de pacientes con EPOC es un predictor independiente de eventos CV (hazard ratio: 1,44; IC 95%: 1,22-1,70), y se relacionó con un aumento de la mortalidad CV en el período de seguimiento (hazard ratio: 1,57; IC 95%: 1,35-1,83). Conclusiones: El análisis sugiere que la identificación de CC en las TC torácicas de pacientes con EPOC puede ser útil en la detección precoz y en el tratamiento de la enfermedad CV en pacientes asintomáticos. Se necesitan estudios prospectivos multicéntricos que confirmen nuestros hallazgos para explorar el impacto potencial de la detección precoz y el tratamiento del riesgo CV en pacientes con EPOC.http://www.sciencedirect.com/science/article/pii/S2659663624000791Calcificación coronariaEventos cardiovascularesEnfermedad pulmonar obstructiva crónica |
| spellingShingle | Miguel Jiménez-Gómez Juan P. de-Torres-Tajes Association Between Coronary Calcium Detection on Chest Computed Tomography and Ischemic Cardiovascular Events and Mortality in Asymptomatic Chronic Obstructive Pulmonary Disease Patients. Systematic Review of the Literature Open Respiratory Archives Calcificación coronaria Eventos cardiovasculares Enfermedad pulmonar obstructiva crónica |
| title | Association Between Coronary Calcium Detection on Chest Computed Tomography and Ischemic Cardiovascular Events and Mortality in Asymptomatic Chronic Obstructive Pulmonary Disease Patients. Systematic Review of the Literature |
| title_full | Association Between Coronary Calcium Detection on Chest Computed Tomography and Ischemic Cardiovascular Events and Mortality in Asymptomatic Chronic Obstructive Pulmonary Disease Patients. Systematic Review of the Literature |
| title_fullStr | Association Between Coronary Calcium Detection on Chest Computed Tomography and Ischemic Cardiovascular Events and Mortality in Asymptomatic Chronic Obstructive Pulmonary Disease Patients. Systematic Review of the Literature |
| title_full_unstemmed | Association Between Coronary Calcium Detection on Chest Computed Tomography and Ischemic Cardiovascular Events and Mortality in Asymptomatic Chronic Obstructive Pulmonary Disease Patients. Systematic Review of the Literature |
| title_short | Association Between Coronary Calcium Detection on Chest Computed Tomography and Ischemic Cardiovascular Events and Mortality in Asymptomatic Chronic Obstructive Pulmonary Disease Patients. Systematic Review of the Literature |
| title_sort | association between coronary calcium detection on chest computed tomography and ischemic cardiovascular events and mortality in asymptomatic chronic obstructive pulmonary disease patients systematic review of the literature |
| topic | Calcificación coronaria Eventos cardiovasculares Enfermedad pulmonar obstructiva crónica |
| url | http://www.sciencedirect.com/science/article/pii/S2659663624000791 |
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