PARP Inhibition Attenuates Histopathological Lesion in Ischemia/Reperfusion Renal Mouse Model after Cold Prolonged Ischemia

PARP Inhibition Attenuates Histopathological Lesion in Ischemia/Reperfusion Renal Mouse Model after Cold Prolonged Ischemia

We test the hypothesis that PARP inhibition can decrease acute tubular necrosis (ATN) and other renal lesions related to prolonged cold ischemia/reperfusion (IR) in kidneys preserved at 4°C in University of Wisconsin (UW) solution. Material and Methods. We used 30 male Parp1+/+ wild-type and 15 male...

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Main Authors: Raimundo M. G. del Moral, Mercedes Gómez-Morales, Pedro Hernández-Cortés, David Aguilar, Trinidad Caballero, Jose Aneiros-Fernández, Mercedes Caba-Molina, Mª  Dolores Rodríguez-Martínez, Andreina Peralta, Pablo Galindo-Moreno, Antonio Osuna, F. Javier Oliver, Raimundo G. del Moral, Francisco O'Valle
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1155/2013/486574
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