Factors Associated with Unfavorable Treatment Outcomes in New and Previously Treated TB Patients in Uzbekistan: A Five Year Countrywide Study.
<h4>Background</h4>TB is one of the main health priorities in Uzbekistan and relatively high rates of unfavorable treatment outcomes have recently been reported. This requires closer analysis to explain the reasons and recommend interventions to improve the situation. Thus, by using coun...
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Public Library of Science (PLoS)
2015-01-01
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| author | Jamshid Gadoev Damin Asadov Mirzagolib Tillashaykhov Katie Tayler-Smith Petros Isaakidis Andrei Dadu Pierpaolo de Colombani Sven Gudmund Hinderaker Nargiza Parpieva Dilrabo Ulmasova Avazbek Jalolov Atadjan Hamraev Engy Ali Martin van den Boom Asmus Hammerich Ogtay Gozalov Masoud Dara |
| author_facet | Jamshid Gadoev Damin Asadov Mirzagolib Tillashaykhov Katie Tayler-Smith Petros Isaakidis Andrei Dadu Pierpaolo de Colombani Sven Gudmund Hinderaker Nargiza Parpieva Dilrabo Ulmasova Avazbek Jalolov Atadjan Hamraev Engy Ali Martin van den Boom Asmus Hammerich Ogtay Gozalov Masoud Dara |
| author_sort | Jamshid Gadoev |
| collection | DOAJ |
| description | <h4>Background</h4>TB is one of the main health priorities in Uzbekistan and relatively high rates of unfavorable treatment outcomes have recently been reported. This requires closer analysis to explain the reasons and recommend interventions to improve the situation. Thus, by using countrywide data this study sought to determine trends in unfavorable outcomes (lost-to-follow-ups, deaths and treatment failures) and describe their associations with socio-demographic and clinical factors.<h4>Method</h4>A countrywide retrospective cohort study of all new and previously treated TB patients registered in the National Tuberculosis programme between January 2006 and December 2010.<h4>Results</h4>Among 107,380 registered patients, 67% were adults, with smaller proportions of children (10%), adolescents (4%) and elderly patients (19%). Sixty per cent were male, 66% lived in rural areas, 1% were HIV-infected and 1% had a history of imprisonment. Pulmonary TB (PTB) was present in 77%, of which 43% were smear-positive and 53% were smear-negative. Overall, 83% of patients were successfully treated, 6% died, 6% were lost-to-follow-up, 3% failed treatment and 2% transferred out. Factors associated with death included being above 55 years of age, HIV-positive, sputum smear positive, previously treated, jobless and living in certain provinces. Factors associated with lost-to-follow-up were being male, previously treated, jobless, living in an urban area, and living in certain provinces. Having smear-positive PTB, being an adolescent, being urban population, being HIV-negative, previously treated, jobless and residing in particular provinces were associated with treatment failure.<h4>Conclusion</h4>Overall, 83% treatment success rate was achieved. However, our study findings highlight the need to improve TB services for certain vulnerable groups and in specific areas of the country. They also emphasize the need to develop unified monitoring and evaluation tools for drug-susceptible and drug-resistant TB, and call for better TB surveillance and coordination between provinces and neighbouring countries. |
| format | Article |
| id | doaj-art-2b2e115ea671485b83c2e2c6a13cb195 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-2b2e115ea671485b83c2e2c6a13cb1952025-08-20T02:34:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e012890710.1371/journal.pone.0128907Factors Associated with Unfavorable Treatment Outcomes in New and Previously Treated TB Patients in Uzbekistan: A Five Year Countrywide Study.Jamshid GadoevDamin AsadovMirzagolib TillashaykhovKatie Tayler-SmithPetros IsaakidisAndrei DaduPierpaolo de ColombaniSven Gudmund HinderakerNargiza ParpievaDilrabo UlmasovaAvazbek JalolovAtadjan HamraevEngy AliMartin van den BoomAsmus HammerichOgtay GozalovMasoud Dara<h4>Background</h4>TB is one of the main health priorities in Uzbekistan and relatively high rates of unfavorable treatment outcomes have recently been reported. This requires closer analysis to explain the reasons and recommend interventions to improve the situation. Thus, by using countrywide data this study sought to determine trends in unfavorable outcomes (lost-to-follow-ups, deaths and treatment failures) and describe their associations with socio-demographic and clinical factors.<h4>Method</h4>A countrywide retrospective cohort study of all new and previously treated TB patients registered in the National Tuberculosis programme between January 2006 and December 2010.<h4>Results</h4>Among 107,380 registered patients, 67% were adults, with smaller proportions of children (10%), adolescents (4%) and elderly patients (19%). Sixty per cent were male, 66% lived in rural areas, 1% were HIV-infected and 1% had a history of imprisonment. Pulmonary TB (PTB) was present in 77%, of which 43% were smear-positive and 53% were smear-negative. Overall, 83% of patients were successfully treated, 6% died, 6% were lost-to-follow-up, 3% failed treatment and 2% transferred out. Factors associated with death included being above 55 years of age, HIV-positive, sputum smear positive, previously treated, jobless and living in certain provinces. Factors associated with lost-to-follow-up were being male, previously treated, jobless, living in an urban area, and living in certain provinces. Having smear-positive PTB, being an adolescent, being urban population, being HIV-negative, previously treated, jobless and residing in particular provinces were associated with treatment failure.<h4>Conclusion</h4>Overall, 83% treatment success rate was achieved. However, our study findings highlight the need to improve TB services for certain vulnerable groups and in specific areas of the country. They also emphasize the need to develop unified monitoring and evaluation tools for drug-susceptible and drug-resistant TB, and call for better TB surveillance and coordination between provinces and neighbouring countries.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0128907&type=printable |
| spellingShingle | Jamshid Gadoev Damin Asadov Mirzagolib Tillashaykhov Katie Tayler-Smith Petros Isaakidis Andrei Dadu Pierpaolo de Colombani Sven Gudmund Hinderaker Nargiza Parpieva Dilrabo Ulmasova Avazbek Jalolov Atadjan Hamraev Engy Ali Martin van den Boom Asmus Hammerich Ogtay Gozalov Masoud Dara Factors Associated with Unfavorable Treatment Outcomes in New and Previously Treated TB Patients in Uzbekistan: A Five Year Countrywide Study. PLoS ONE |
| title | Factors Associated with Unfavorable Treatment Outcomes in New and Previously Treated TB Patients in Uzbekistan: A Five Year Countrywide Study. |
| title_full | Factors Associated with Unfavorable Treatment Outcomes in New and Previously Treated TB Patients in Uzbekistan: A Five Year Countrywide Study. |
| title_fullStr | Factors Associated with Unfavorable Treatment Outcomes in New and Previously Treated TB Patients in Uzbekistan: A Five Year Countrywide Study. |
| title_full_unstemmed | Factors Associated with Unfavorable Treatment Outcomes in New and Previously Treated TB Patients in Uzbekistan: A Five Year Countrywide Study. |
| title_short | Factors Associated with Unfavorable Treatment Outcomes in New and Previously Treated TB Patients in Uzbekistan: A Five Year Countrywide Study. |
| title_sort | factors associated with unfavorable treatment outcomes in new and previously treated tb patients in uzbekistan a five year countrywide study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0128907&type=printable |
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