Realizing the Promise of Artificial Intelligence in Hepatocellular Carcinoma through Opportunities and Recommendations for Responsible Translation

This study aims to provide an overview of the current state-of-the-art applications of artificial intelligence (AI) and machine learning in the management of hepatocellular carcinoma (HCC), and to explore future directions for continued progress in this emerging field.  This study is a comprehensive...

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Main Authors: Tamer Addissouky, Majeed M. A. Ali, Ibrahim El Tantawy El Sayed, Mahmood Hasen Shuhata Alubiady
Format: Article
Language:English
Published: Department of Informatics, UIN Sunan Gunung Djati Bandung 2024-04-01
Series:JOIN: Jurnal Online Informatika
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Online Access:https://join.if.uinsgd.ac.id/index.php/join/article/view/1297
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author Tamer Addissouky
Majeed M. A. Ali
Ibrahim El Tantawy El Sayed
Mahmood Hasen Shuhata Alubiady
author_facet Tamer Addissouky
Majeed M. A. Ali
Ibrahim El Tantawy El Sayed
Mahmood Hasen Shuhata Alubiady
author_sort Tamer Addissouky
collection DOAJ
description This study aims to provide an overview of the current state-of-the-art applications of artificial intelligence (AI) and machine learning in the management of hepatocellular carcinoma (HCC), and to explore future directions for continued progress in this emerging field.  This study is a comprehensive literature review that synthesizes recent findings and advancements in the application of AI and machine learning techniques across various aspects of HCC care, including screening and early detection, diagnosis and staging, prognostic modeling, treatment planning, interventional guidance, and monitoring of treatment response. The review draws upon a wide range of published research studies, focusing on the integration of AI and machine learning with diverse data sources, such as medical imaging, clinical data, genomics, and other multimodal information.  The results demonstrate that AI-based systems have shown promise in improving the accuracy and efficiency of HCC screening, diagnosis, and tumor characterization compared to traditional methods. Machine learning models integrating clinical, imaging, and genomic data have outperformed conventional staging systems in predicting survival and recurrence risk. AI-based recommendation systems have the potential to optimize personalized therapy selection, while augmented reality techniques can guide interventional procedures in real-time. Moreover, longitudinal application of AI may enhance the assessment of treatment response and recurrence monitoring. Despite these promising findings, the review highlights the need for rigorous multicenter prospective validation studies, standardized multimodal datasets, and thoughtful consideration of ethical implications before widespread clinical implementation of AI technologies in HCC management.
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spelling doaj-art-2b243115389644c98ac10708d807c8ff2025-08-20T02:33:52ZengDepartment of Informatics, UIN Sunan Gunung Djati BandungJOIN: Jurnal Online Informatika2528-16822527-91652024-04-0191707910.15575/join.v9i1.12971340Realizing the Promise of Artificial Intelligence in Hepatocellular Carcinoma through Opportunities and Recommendations for Responsible TranslationTamer Addissouky0https://orcid.org/0000-0003-3797-9155Majeed M. A. Ali1Ibrahim El Tantawy El Sayed2Mahmood Hasen Shuhata Alubiady3Department of Biochemistry, Science Faculty, Menoufia University, Menoufia; Al-Hadi University College, Baghdad, Iraq; MLS ASCP, United States; MLS Ministry of Health, AlexandriaAl-Hadi University College, BaghdadDepartment of Biochemistry, Science Faculty, Menoufia University, MenoufiaAl-Hadi University College, BaghdadThis study aims to provide an overview of the current state-of-the-art applications of artificial intelligence (AI) and machine learning in the management of hepatocellular carcinoma (HCC), and to explore future directions for continued progress in this emerging field.  This study is a comprehensive literature review that synthesizes recent findings and advancements in the application of AI and machine learning techniques across various aspects of HCC care, including screening and early detection, diagnosis and staging, prognostic modeling, treatment planning, interventional guidance, and monitoring of treatment response. The review draws upon a wide range of published research studies, focusing on the integration of AI and machine learning with diverse data sources, such as medical imaging, clinical data, genomics, and other multimodal information.  The results demonstrate that AI-based systems have shown promise in improving the accuracy and efficiency of HCC screening, diagnosis, and tumor characterization compared to traditional methods. Machine learning models integrating clinical, imaging, and genomic data have outperformed conventional staging systems in predicting survival and recurrence risk. AI-based recommendation systems have the potential to optimize personalized therapy selection, while augmented reality techniques can guide interventional procedures in real-time. Moreover, longitudinal application of AI may enhance the assessment of treatment response and recurrence monitoring. Despite these promising findings, the review highlights the need for rigorous multicenter prospective validation studies, standardized multimodal datasets, and thoughtful consideration of ethical implications before widespread clinical implementation of AI technologies in HCC management.https://join.if.uinsgd.ac.id/index.php/join/article/view/1297artificial intelligencedeep learningimagingmachine learninghepatocellular carcinoma
spellingShingle Tamer Addissouky
Majeed M. A. Ali
Ibrahim El Tantawy El Sayed
Mahmood Hasen Shuhata Alubiady
Realizing the Promise of Artificial Intelligence in Hepatocellular Carcinoma through Opportunities and Recommendations for Responsible Translation
JOIN: Jurnal Online Informatika
artificial intelligence
deep learning
imaging
machine learning
hepatocellular carcinoma
title Realizing the Promise of Artificial Intelligence in Hepatocellular Carcinoma through Opportunities and Recommendations for Responsible Translation
title_full Realizing the Promise of Artificial Intelligence in Hepatocellular Carcinoma through Opportunities and Recommendations for Responsible Translation
title_fullStr Realizing the Promise of Artificial Intelligence in Hepatocellular Carcinoma through Opportunities and Recommendations for Responsible Translation
title_full_unstemmed Realizing the Promise of Artificial Intelligence in Hepatocellular Carcinoma through Opportunities and Recommendations for Responsible Translation
title_short Realizing the Promise of Artificial Intelligence in Hepatocellular Carcinoma through Opportunities and Recommendations for Responsible Translation
title_sort realizing the promise of artificial intelligence in hepatocellular carcinoma through opportunities and recommendations for responsible translation
topic artificial intelligence
deep learning
imaging
machine learning
hepatocellular carcinoma
url https://join.if.uinsgd.ac.id/index.php/join/article/view/1297
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