Role of environmental pollutants-induced ferroptosis in pulmonary diseases
Respiratory diseases rank among the foremost causes of mortality and disability globally, with long-term exposure to environmental pollutants playing a critical role in their onset and progression. Despite this, the underlying mechanisms and effective targeted treatments for these disorders remain p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1542275/full |
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| author | Long Yang Yongkang Qiao Zeyu Huang Yuzhu Chen Enxi Zhang Zhiwei Liu Yuxuan Wang Shaobo Chen Shaobo Chen Jinrui Dong Bin Liu Bin Liu |
| author_facet | Long Yang Yongkang Qiao Zeyu Huang Yuzhu Chen Enxi Zhang Zhiwei Liu Yuxuan Wang Shaobo Chen Shaobo Chen Jinrui Dong Bin Liu Bin Liu |
| author_sort | Long Yang |
| collection | DOAJ |
| description | Respiratory diseases rank among the foremost causes of mortality and disability globally, with long-term exposure to environmental pollutants playing a critical role in their onset and progression. Despite this, the underlying mechanisms and effective targeted treatments for these disorders remain poorly understood, highlighting an urgent need for focused research. Cell death, a programmed cellular response to external harmful stimuli, including ferroptosis—a recently identified form of iron-dependent programmed cell death—emerges as a pivotal process. Characterized by intracellular iron accumulation and lipid peroxidation, ferroptosis appears intricately linked to lung injury induced by environmental pollutants. This review examines the role of ferroptosis in lung diseases triggered by environmental factors, aiming to shed light on its specific pathophysiological mechanisms and potential as a therapeutic target. By deepening our understanding of the interactions between environmental pollution, ferroptosis, and lung damage, we hope to inform strategies for effective intervention. |
| format | Article |
| id | doaj-art-2b218ce7f8094db5ae65225cacd5516a |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-2b218ce7f8094db5ae65225cacd5516a2025-08-20T02:45:03ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.15422751542275Role of environmental pollutants-induced ferroptosis in pulmonary diseasesLong Yang0Yongkang Qiao1Zeyu Huang2Yuzhu Chen3Enxi Zhang4Zhiwei Liu5Yuxuan Wang6Shaobo Chen7Shaobo Chen8Jinrui Dong9Bin Liu10Bin Liu11Integrated Medical Center, Tianjin University, Tianjin, ChinaKey Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Beijing Normal University, Zhuhai, Guangdong, ChinaAcademy of Medical Engineering and Translational Medicine, School of Medicine, Tianjin University, Tianjin, ChinaSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin, ChinaAcademy of Medical Engineering and Translational Medicine, School of Medicine, Tianjin University, Tianjin, ChinaAcademy of Medical Engineering and Translational Medicine, School of Medicine, Tianjin University, Tianjin, ChinaSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin, ChinaIntegrated Medical Center, Tianjin University, Tianjin, ChinaInstitute of Plateau and Cold-Resistant Environment and Cardiovascular Disease Prevention and Treatment, Specialty Medical Center of Chinese People’s Armed Police Force, Tianjin, ChinaAcademy of Medical Engineering and Translational Medicine, School of Medicine, Tianjin University, Tianjin, ChinaIntegrated Medical Center, Tianjin University, Tianjin, ChinaDepartment of Infectious Diseases, Specialty Medical Center of Chinese People’s Armed Police Force, Tianjin, ChinaRespiratory diseases rank among the foremost causes of mortality and disability globally, with long-term exposure to environmental pollutants playing a critical role in their onset and progression. Despite this, the underlying mechanisms and effective targeted treatments for these disorders remain poorly understood, highlighting an urgent need for focused research. Cell death, a programmed cellular response to external harmful stimuli, including ferroptosis—a recently identified form of iron-dependent programmed cell death—emerges as a pivotal process. Characterized by intracellular iron accumulation and lipid peroxidation, ferroptosis appears intricately linked to lung injury induced by environmental pollutants. This review examines the role of ferroptosis in lung diseases triggered by environmental factors, aiming to shed light on its specific pathophysiological mechanisms and potential as a therapeutic target. By deepening our understanding of the interactions between environmental pollution, ferroptosis, and lung damage, we hope to inform strategies for effective intervention.https://www.frontiersin.org/articles/10.3389/fmed.2025.1542275/fullferroptosislungenvironmental pollutantsironredox |
| spellingShingle | Long Yang Yongkang Qiao Zeyu Huang Yuzhu Chen Enxi Zhang Zhiwei Liu Yuxuan Wang Shaobo Chen Shaobo Chen Jinrui Dong Bin Liu Bin Liu Role of environmental pollutants-induced ferroptosis in pulmonary diseases Frontiers in Medicine ferroptosis lung environmental pollutants iron redox |
| title | Role of environmental pollutants-induced ferroptosis in pulmonary diseases |
| title_full | Role of environmental pollutants-induced ferroptosis in pulmonary diseases |
| title_fullStr | Role of environmental pollutants-induced ferroptosis in pulmonary diseases |
| title_full_unstemmed | Role of environmental pollutants-induced ferroptosis in pulmonary diseases |
| title_short | Role of environmental pollutants-induced ferroptosis in pulmonary diseases |
| title_sort | role of environmental pollutants induced ferroptosis in pulmonary diseases |
| topic | ferroptosis lung environmental pollutants iron redox |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1542275/full |
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