The influence of type 2 diabetes mellitus on the frequency and complexity of ventricular arrhythmias and heart rate variability in patients after myocardial infarction
Background/Aim. After myocardial infarction arrhythmic cardiac deaths are significantly more frequent compared to non-arrhythmic ones. The aim of the study was to investigate the influence of type 2 diabetes mellitus (T2DM) on the frequency and complexity of ventricular arrhythmias after myocardial...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2016-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600219S.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849307635168313344 |
|---|---|
| author | Stoičkov Viktor Deljanin-Ilić Marina Stojanović Dijana Ilić Stevan Šarić Sandra Petrović Dejan Kostić Tomislav Cvetković Jovana Stojanović Sanja Golubović Mlađan |
| author_facet | Stoičkov Viktor Deljanin-Ilić Marina Stojanović Dijana Ilić Stevan Šarić Sandra Petrović Dejan Kostić Tomislav Cvetković Jovana Stojanović Sanja Golubović Mlađan |
| author_sort | Stoičkov Viktor |
| collection | DOAJ |
| description | Background/Aim. After myocardial infarction arrhythmic cardiac deaths are significantly more frequent compared to non-arrhythmic ones. The aim of the study was to investigate the influence of type 2 diabetes mellitus (T2DM) on the frequency and complexity of ventricular arrhythmias after myocardial infarction. Methods. The study included 293 patients, mean age 59.5 ± 9.21 years, who were at least six months after acute myocardial infarction with the sinus rhythm, without atrioventricular blocks and branch blocks. In the clinical group 95 (32.42%) patients were with T2DM, while 198 (67.57%) patients were without diabetes. All of the patients were subjected to the following procedures: standard ECG according to which the corrected QT dispersion (QTdc) was calculated, exercise stress test, and 24-hour holter monitoring according to which, the four parameters of time domain of heart rate variability (HRV) were analyzed: standard deviation of all normal RR intervals during 24 hours (SDNN), standard deviation of the averages of normal RR intervals in all five-minute segments during 24 hours (SDANN), the square root of the mean of the sum of the squares of differences between adjacent normal (RMS-SD), and percentage of consequtive RR intervals which differed for more than 50 ms during 24 hours (NN > 50 ms). Results. In patients after myocardial infarction, patients with T2DM had significantly higher percentage of frequent and complex ventricular arrhythmias compared to the patients without diabetes (p < 0.001). The patients with T2DM had significantly higher percentage of residual ischemia (p < 0.001), and arterial hypertension (p < 0.001), compared to patients without diabetes. The patients with T2DM had significantly lower values of HRV parameters: SDNN (p < 0.001); SDANN (p < 0.001); RMS-SD (p < 0.001), and NN > 50 ms (p < 0.001), and significantly higher values of QTdc (p < 0.001) compared to the patients without diabetes. Conclusion. The study showed that type 2 diabetes mellitus has significant influence on ventricular arrhythmias, HRV parameters and QT dispersion in patients after myocardial infarction. |
| format | Article |
| id | doaj-art-2b1bf2989802418c8e15c6d1e6003aa6 |
| institution | Kabale University |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-2b1bf2989802418c8e15c6d1e6003aa62025-08-20T03:54:42ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202016-01-0173111050105510.2298/VSP150303219S0042-84501600219SThe influence of type 2 diabetes mellitus on the frequency and complexity of ventricular arrhythmias and heart rate variability in patients after myocardial infarctionStoičkov Viktor0Deljanin-Ilić Marina1Stojanović Dijana2Ilić Stevan3Šarić Sandra4Petrović Dejan5Kostić Tomislav6Cvetković Jovana7Stojanović Sanja8Golubović Mlađan9Institute for Treatment and Rehabilitation “Niška Banja”, Niška Banja + Faculty of Medicine, Department of Internal Medicine, NišInstitute for Treatment and Rehabilitation “Niška Banja”, Niška Banja + Faculty of Medicine, Department of Internal Medicine, NišFaculty of Medicine, Institute of Pathophysiology, NišInstitute for Treatment and Rehabilitation “Niška Banja”, Niška Banja + Faculty of Medicine, Department of Internal Medicine, NišInstitute for Treatment and Rehabilitation “Niška Banja”, Niška Banja Institute for Treatment and Rehabilitation “Niška Banja”, Niška Banja Clinical Center Niš, Clinic for Cardiovascular Diseases, NišInstitute for Treatment and Rehabilitation “Niška Banja”, Niška Banja Institute for Treatment and Rehabilitation “Niška Banja”, Niška Banja Clinical Center Niš, Center for Anesthesiology and Intensive care, NišBackground/Aim. After myocardial infarction arrhythmic cardiac deaths are significantly more frequent compared to non-arrhythmic ones. The aim of the study was to investigate the influence of type 2 diabetes mellitus (T2DM) on the frequency and complexity of ventricular arrhythmias after myocardial infarction. Methods. The study included 293 patients, mean age 59.5 ± 9.21 years, who were at least six months after acute myocardial infarction with the sinus rhythm, without atrioventricular blocks and branch blocks. In the clinical group 95 (32.42%) patients were with T2DM, while 198 (67.57%) patients were without diabetes. All of the patients were subjected to the following procedures: standard ECG according to which the corrected QT dispersion (QTdc) was calculated, exercise stress test, and 24-hour holter monitoring according to which, the four parameters of time domain of heart rate variability (HRV) were analyzed: standard deviation of all normal RR intervals during 24 hours (SDNN), standard deviation of the averages of normal RR intervals in all five-minute segments during 24 hours (SDANN), the square root of the mean of the sum of the squares of differences between adjacent normal (RMS-SD), and percentage of consequtive RR intervals which differed for more than 50 ms during 24 hours (NN > 50 ms). Results. In patients after myocardial infarction, patients with T2DM had significantly higher percentage of frequent and complex ventricular arrhythmias compared to the patients without diabetes (p < 0.001). The patients with T2DM had significantly higher percentage of residual ischemia (p < 0.001), and arterial hypertension (p < 0.001), compared to patients without diabetes. The patients with T2DM had significantly lower values of HRV parameters: SDNN (p < 0.001); SDANN (p < 0.001); RMS-SD (p < 0.001), and NN > 50 ms (p < 0.001), and significantly higher values of QTdc (p < 0.001) compared to the patients without diabetes. Conclusion. The study showed that type 2 diabetes mellitus has significant influence on ventricular arrhythmias, HRV parameters and QT dispersion in patients after myocardial infarction.http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600219S.pdfdiabetes melitus type 2arrhythmias, cardiacmyocardial infarction |
| spellingShingle | Stoičkov Viktor Deljanin-Ilić Marina Stojanović Dijana Ilić Stevan Šarić Sandra Petrović Dejan Kostić Tomislav Cvetković Jovana Stojanović Sanja Golubović Mlađan The influence of type 2 diabetes mellitus on the frequency and complexity of ventricular arrhythmias and heart rate variability in patients after myocardial infarction Vojnosanitetski Pregled diabetes melitus type 2 arrhythmias, cardiac myocardial infarction |
| title | The influence of type 2 diabetes mellitus on the frequency and complexity of ventricular arrhythmias and heart rate variability in patients after myocardial infarction |
| title_full | The influence of type 2 diabetes mellitus on the frequency and complexity of ventricular arrhythmias and heart rate variability in patients after myocardial infarction |
| title_fullStr | The influence of type 2 diabetes mellitus on the frequency and complexity of ventricular arrhythmias and heart rate variability in patients after myocardial infarction |
| title_full_unstemmed | The influence of type 2 diabetes mellitus on the frequency and complexity of ventricular arrhythmias and heart rate variability in patients after myocardial infarction |
| title_short | The influence of type 2 diabetes mellitus on the frequency and complexity of ventricular arrhythmias and heart rate variability in patients after myocardial infarction |
| title_sort | influence of type 2 diabetes mellitus on the frequency and complexity of ventricular arrhythmias and heart rate variability in patients after myocardial infarction |
| topic | diabetes melitus type 2 arrhythmias, cardiac myocardial infarction |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600219S.pdf |
| work_keys_str_mv | AT stoickovviktor theinfluenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT deljaninilicmarina theinfluenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT stojanovicdijana theinfluenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT ilicstevan theinfluenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT saricsandra theinfluenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT petrovicdejan theinfluenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT kostictomislav theinfluenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT cvetkovicjovana theinfluenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT stojanovicsanja theinfluenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT golubovicmlađan theinfluenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT stoickovviktor influenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT deljaninilicmarina influenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT stojanovicdijana influenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT ilicstevan influenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT saricsandra influenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT petrovicdejan influenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT kostictomislav influenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT cvetkovicjovana influenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT stojanovicsanja influenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction AT golubovicmlađan influenceoftype2diabetesmellitusonthefrequencyandcomplexityofventriculararrhythmiasandheartratevariabilityinpatientsaftermyocardialinfarction |