Multisystemic impact of autosomal dominant polycystic kidney disease: A case report highlighting renal, hepatic, and neurological involvement
We present a case of a 64-year-old male with Autosomal Dominant Polycystic Kidney Disease (ADPKD), characterized by systemic involvement, including renal, hepatic, and neurological complications. The patient presented with persistent micturition difficulties, hematuria, and abdominal pain, compounde...
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Elsevier
2025-04-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043325000196 |
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| author | Ibrahim Khalil, MBBS Ahmed Fahim Faiyaz, MBBS Md. Imran Hossain, MBBS Mahmuda Akter, MBBS |
| author_facet | Ibrahim Khalil, MBBS Ahmed Fahim Faiyaz, MBBS Md. Imran Hossain, MBBS Mahmuda Akter, MBBS |
| author_sort | Ibrahim Khalil, MBBS |
| collection | DOAJ |
| description | We present a case of a 64-year-old male with Autosomal Dominant Polycystic Kidney Disease (ADPKD), characterized by systemic involvement, including renal, hepatic, and neurological complications. The patient presented with persistent micturition difficulties, hematuria, and abdominal pain, compounded by hypertension and chronic obstructive pulmonary disease. Imaging revealed bilateral renal enlargement with hemorrhagic cysts, a kidney stone, and hepatic cysts causing hepatomegaly. Neurological evaluation identified chronic and recent intracerebral hemorrhages associated with poorly controlled hypertension, underscoring ADPKD's multisystem impact. ADPKD, caused by PKD1 or PKD2 mutations, often leads to progressive renal dysfunction, hypertension, and extrarenal manifestations such as hepatic cysts and intracranial aneurysms. Advances like tolvaptan demonstrate efficacy in slowing renal disease progression, while somatostatin analogs offer promise for hepatic cyst management. This case emphasizes the necessity of a multidisciplinary approach, including strict blood pressure control, regular imaging, and pharmacological intervention, to address ADPKD's complexities and optimize patient outcomes. Early diagnosis and vigilant monitoring remain crucial for preventing complications and enhancing quality of life. This report underscores the importance of integrated care in managing ADPKD, highlighting emerging therapies and the ongoing need for personalized treatment strategies in such challenging cases. |
| format | Article |
| id | doaj-art-2b1b66449d4b4306b6d7e6ceb99fc6ae |
| institution | Kabale University |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-2b1b66449d4b4306b6d7e6ceb99fc6ae2025-01-31T05:11:12ZengElsevierRadiology Case Reports1930-04332025-04-0120420932100Multisystemic impact of autosomal dominant polycystic kidney disease: A case report highlighting renal, hepatic, and neurological involvementIbrahim Khalil, MBBS0Ahmed Fahim Faiyaz, MBBS1Md. Imran Hossain, MBBS2Mahmuda Akter, MBBS3Dhaka Medical College and Hospital, Dhaka, Bangladesh; Corresponding author.Dhaka Medical College and Hospital, Dhaka, BangladeshFaculty of Medicine, Dhaka University, Dhaka, BangladeshFaculty of Medicine, Dhaka University, Dhaka, BangladeshWe present a case of a 64-year-old male with Autosomal Dominant Polycystic Kidney Disease (ADPKD), characterized by systemic involvement, including renal, hepatic, and neurological complications. The patient presented with persistent micturition difficulties, hematuria, and abdominal pain, compounded by hypertension and chronic obstructive pulmonary disease. Imaging revealed bilateral renal enlargement with hemorrhagic cysts, a kidney stone, and hepatic cysts causing hepatomegaly. Neurological evaluation identified chronic and recent intracerebral hemorrhages associated with poorly controlled hypertension, underscoring ADPKD's multisystem impact. ADPKD, caused by PKD1 or PKD2 mutations, often leads to progressive renal dysfunction, hypertension, and extrarenal manifestations such as hepatic cysts and intracranial aneurysms. Advances like tolvaptan demonstrate efficacy in slowing renal disease progression, while somatostatin analogs offer promise for hepatic cyst management. This case emphasizes the necessity of a multidisciplinary approach, including strict blood pressure control, regular imaging, and pharmacological intervention, to address ADPKD's complexities and optimize patient outcomes. Early diagnosis and vigilant monitoring remain crucial for preventing complications and enhancing quality of life. This report underscores the importance of integrated care in managing ADPKD, highlighting emerging therapies and the ongoing need for personalized treatment strategies in such challenging cases.http://www.sciencedirect.com/science/article/pii/S1930043325000196Autosomal dominant polycystic kidney diseaseMultisystem involvementRenal cystsHepatic cystsIntracranial hemorrhage |
| spellingShingle | Ibrahim Khalil, MBBS Ahmed Fahim Faiyaz, MBBS Md. Imran Hossain, MBBS Mahmuda Akter, MBBS Multisystemic impact of autosomal dominant polycystic kidney disease: A case report highlighting renal, hepatic, and neurological involvement Radiology Case Reports Autosomal dominant polycystic kidney disease Multisystem involvement Renal cysts Hepatic cysts Intracranial hemorrhage |
| title | Multisystemic impact of autosomal dominant polycystic kidney disease: A case report highlighting renal, hepatic, and neurological involvement |
| title_full | Multisystemic impact of autosomal dominant polycystic kidney disease: A case report highlighting renal, hepatic, and neurological involvement |
| title_fullStr | Multisystemic impact of autosomal dominant polycystic kidney disease: A case report highlighting renal, hepatic, and neurological involvement |
| title_full_unstemmed | Multisystemic impact of autosomal dominant polycystic kidney disease: A case report highlighting renal, hepatic, and neurological involvement |
| title_short | Multisystemic impact of autosomal dominant polycystic kidney disease: A case report highlighting renal, hepatic, and neurological involvement |
| title_sort | multisystemic impact of autosomal dominant polycystic kidney disease a case report highlighting renal hepatic and neurological involvement |
| topic | Autosomal dominant polycystic kidney disease Multisystem involvement Renal cysts Hepatic cysts Intracranial hemorrhage |
| url | http://www.sciencedirect.com/science/article/pii/S1930043325000196 |
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