Comparison between intrathecal fentanyl and dexmedetomidine as an adjuvant to hyperbaric 0.5% levobupivacaine in subarachnoid block for cesarean section: A prospective study
The effect of dexmedetomidine and fentanyl as an adjuvant with hyperbaric levobupivacaine in cesarean section has not been evaluated adequately by researchers until now. The present study is designed to compare the effect of 5 mcg of dexmedetomidine and 25 mcg fentanyl when added to intrathecal 0.5%...
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Serbian Society of Anesthesiologists and Intensivists
2025-01-01
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| Series: | Serbian Journal of Anesthesia and Intensive Therapy |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2217-7744/2025/2217-77442501023B.pdf |
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| author | Bhar Debasish Saha Santanu Chattopadhyay Suman Datta Sagnik Paul Anusree |
| author_facet | Bhar Debasish Saha Santanu Chattopadhyay Suman Datta Sagnik Paul Anusree |
| author_sort | Bhar Debasish |
| collection | DOAJ |
| description | The effect of dexmedetomidine and fentanyl as an adjuvant with hyperbaric levobupivacaine in cesarean section has not been evaluated adequately by researchers until now. The present study is designed to compare the effect of 5 mcg of dexmedetomidine and 25 mcg fentanyl when added to intrathecal 0.5% hyperbaric levobupivacaine for cesarean section. This randomized controlled trial was done with 105 parturient undergoing cesarean section under spinal anesthesia. Parturient were randomly divided into three groups. Group DL received 5 mcg of dexmedetomidine along with 1.8 ml of hyperbaric levobupivacaine intrathecally. Group FL and group NL received 25 mcg of fentanyl and 0.5 ml of normal saline respectively along with 0.5% hyperbaric levobupivacaine. The primary objective was to compare the duration of sensory and motor block among the groups. Comparing the onset time of sensory and motor block and time to first analgesic medication was considered a secondary objective. Duration of sensory block was 138.14 ± 14.35 and 131.86 ± 7.85 min in group DL and FL (P < 0.05). Motor block duration was 250.2 ± 6.86 and 242.63 ± 4.71 min in group DL and FL respectively (P < 0.05). The time to first analgesic medication in group DL (273.43 ± 7.54 vs. 253.43 ± 6.52 min) was significantly prolonged compared to group FL (P < 0.001). A 5 mcg dose of dexmedetomidine when used as an adjuvant to intrathecal 0.5% hyperbaric levobupivacaine significantly prolongs the duration of sensory block, motor block, and the time to first analgesic medication compared to 25 mcg of fentanyl. |
| format | Article |
| id | doaj-art-2b15668807a34ecba722ca4adadeedae |
| institution | OA Journals |
| issn | 2466-488X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Serbian Society of Anesthesiologists and Intensivists |
| record_format | Article |
| series | Serbian Journal of Anesthesia and Intensive Therapy |
| spelling | doaj-art-2b15668807a34ecba722ca4adadeedae2025-08-20T01:50:39ZengSerbian Society of Anesthesiologists and IntensivistsSerbian Journal of Anesthesia and Intensive Therapy2466-488X2025-01-01471-2233010.5937/sjait2502023S2217-77442501023BComparison between intrathecal fentanyl and dexmedetomidine as an adjuvant to hyperbaric 0.5% levobupivacaine in subarachnoid block for cesarean section: A prospective studyBhar Debasish0Saha Santanu1Chattopadhyay Suman2Datta Sagnik3Paul Anusree4Midnapore Medical College, Department of Anesthesiology, Midnapore, West Bengal, IndiaMidnapore Medical College, Department of Anesthesiology, Midnapore, West Bengal, IndiaMidnapore Medical College, Department of Anesthesiology, Midnapore, West Bengal, IndiaMidnapore Medical College, Department of Anesthesiology, Midnapore, West Bengal, IndiaMidnapore Medical College, Department of Anesthesiology, Midnapore, West Bengal, IndiaThe effect of dexmedetomidine and fentanyl as an adjuvant with hyperbaric levobupivacaine in cesarean section has not been evaluated adequately by researchers until now. The present study is designed to compare the effect of 5 mcg of dexmedetomidine and 25 mcg fentanyl when added to intrathecal 0.5% hyperbaric levobupivacaine for cesarean section. This randomized controlled trial was done with 105 parturient undergoing cesarean section under spinal anesthesia. Parturient were randomly divided into three groups. Group DL received 5 mcg of dexmedetomidine along with 1.8 ml of hyperbaric levobupivacaine intrathecally. Group FL and group NL received 25 mcg of fentanyl and 0.5 ml of normal saline respectively along with 0.5% hyperbaric levobupivacaine. The primary objective was to compare the duration of sensory and motor block among the groups. Comparing the onset time of sensory and motor block and time to first analgesic medication was considered a secondary objective. Duration of sensory block was 138.14 ± 14.35 and 131.86 ± 7.85 min in group DL and FL (P < 0.05). Motor block duration was 250.2 ± 6.86 and 242.63 ± 4.71 min in group DL and FL respectively (P < 0.05). The time to first analgesic medication in group DL (273.43 ± 7.54 vs. 253.43 ± 6.52 min) was significantly prolonged compared to group FL (P < 0.001). A 5 mcg dose of dexmedetomidine when used as an adjuvant to intrathecal 0.5% hyperbaric levobupivacaine significantly prolongs the duration of sensory block, motor block, and the time to first analgesic medication compared to 25 mcg of fentanyl.https://scindeks-clanci.ceon.rs/data/pdf/2217-7744/2025/2217-77442501023B.pdfanesthesiaspinaladjuvants, anesthesiacaesarean sectiondexmedetomidinefentanyllevobupivacaine |
| spellingShingle | Bhar Debasish Saha Santanu Chattopadhyay Suman Datta Sagnik Paul Anusree Comparison between intrathecal fentanyl and dexmedetomidine as an adjuvant to hyperbaric 0.5% levobupivacaine in subarachnoid block for cesarean section: A prospective study Serbian Journal of Anesthesia and Intensive Therapy anesthesia spinal adjuvants, anesthesia caesarean section dexmedetomidine fentanyl levobupivacaine |
| title | Comparison between intrathecal fentanyl and dexmedetomidine as an adjuvant to hyperbaric 0.5% levobupivacaine in subarachnoid block for cesarean section: A prospective study |
| title_full | Comparison between intrathecal fentanyl and dexmedetomidine as an adjuvant to hyperbaric 0.5% levobupivacaine in subarachnoid block for cesarean section: A prospective study |
| title_fullStr | Comparison between intrathecal fentanyl and dexmedetomidine as an adjuvant to hyperbaric 0.5% levobupivacaine in subarachnoid block for cesarean section: A prospective study |
| title_full_unstemmed | Comparison between intrathecal fentanyl and dexmedetomidine as an adjuvant to hyperbaric 0.5% levobupivacaine in subarachnoid block for cesarean section: A prospective study |
| title_short | Comparison between intrathecal fentanyl and dexmedetomidine as an adjuvant to hyperbaric 0.5% levobupivacaine in subarachnoid block for cesarean section: A prospective study |
| title_sort | comparison between intrathecal fentanyl and dexmedetomidine as an adjuvant to hyperbaric 0 5 levobupivacaine in subarachnoid block for cesarean section a prospective study |
| topic | anesthesia spinal adjuvants, anesthesia caesarean section dexmedetomidine fentanyl levobupivacaine |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2217-7744/2025/2217-77442501023B.pdf |
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