Causal relationship between educational attainment and the occurrence of venous thromboembolism

Causal relationship between educational attainment and the occurrence of venous thromboembolism

Abstract Background The association between educational attainment (EA) and arterial thrombotic disease has been reported, but the causal relationship between EA and venous thromboembolism (VTE) is not clear. We aimed to assess the causal effect of EA on VTE using the two-sample mendelian randomizat...

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Bibliographic Details
Main Authors: Sitong Guo, Sitao Tan, Shiran Qin, Dandan Xu, Henghai Su, Xiaoyu Chen
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Medical Genomics
Subjects:
Educational attainment
Venous thromboembolism
Mendelian randomization
Causal association
Risk factor
Online Access:https://doi.org/10.1186/s12920-025-02092-w
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Summary:Abstract Background The association between educational attainment (EA) and arterial thrombotic disease has been reported, but the causal relationship between EA and venous thromboembolism (VTE) is not clear. We aimed to assess the causal effect of EA on VTE using the two-sample mendelian randomization (MR) method. Methods Data mining was conducted on the genome wide association studies (GWAS), with exposure factor EA and outcome factor VTE. Two-sample Mendelian Randomization (TSMR) analysis was conducted, with the results obtained from the random effects inverse variance weighted method (IVW). Use the MR-Egger method for pleiotropy analysis and leave one method for sensitivity analysis to verify the reliability of the data. Results Genetically predicted decreased EA was associated with a decreased risk of VTE in both the FinnGen consortium and UK Biobank (FinnGen-VTE: OR = 0.848; 95% CI 0.776—0.927; P = 2.84 × 10–4; UKB-VTE OR = 0.996; 95% CI 0.994—0.999; P = 0.008) under a multiplicative random-effects IVW model. Results were consistent in all sensitivity analyses and no horizontal pleiotropy was detected. Conclusions The MR technique instructed a potential inverse causative relationship between EA and occurrence of VTE. Therefore, patients with low EA should be more vigilant about the occurrence of VTE.
ISSN:1755-8794

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