Investigation of propofol, fentanyl, and midazolam-related toxicity and the protective effect of midazolam on THLE-2 cell lines
The widespread use of propofol, fentanyl, and midazolam in intensive care units necessitates a thorough understanding of their potential toxic effects. These sedative-hypnotic agents are frequently administered in combination to manage critically ill patients, raising concerns about their cumulative...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-03-01
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| Series: | Türk Biyokimya Dergisi |
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| Online Access: | https://doi.org/10.1515/tjb-2024-0234 |
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| author | Özgültekin Asu İnan Asuman Bozali Kubra Özkan Beyza Nur Güler Eray Metin |
| author_facet | Özgültekin Asu İnan Asuman Bozali Kubra Özkan Beyza Nur Güler Eray Metin |
| author_sort | Özgültekin Asu |
| collection | DOAJ |
| description | The widespread use of propofol, fentanyl, and midazolam in intensive care units necessitates a thorough understanding of their potential toxic effects. These sedative-hypnotic agents are frequently administered in combination to manage critically ill patients, raising concerns about their cumulative toxicity. To address this, we investigated the cytotoxic and genotoxic effects of these drugs, both individually and in combination, on a human liver epithelial cell line (THLE-2). The liver, as a major organ involved in drug metabolism, is particularly vulnerable to drug-induced toxicity. By evaluating the impact of these agents on liver cells, we aim to gain insights into their potential adverse effects and inform clinical practice. |
| format | Article |
| id | doaj-art-2b0c3ab5f82b4a418cd025bec573a606 |
| institution | DOAJ |
| issn | 1303-829X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Türk Biyokimya Dergisi |
| spelling | doaj-art-2b0c3ab5f82b4a418cd025bec573a6062025-08-20T03:11:07ZengDe GruyterTürk Biyokimya Dergisi1303-829X2025-03-0150222323210.1515/tjb-2024-0234Investigation of propofol, fentanyl, and midazolam-related toxicity and the protective effect of midazolam on THLE-2 cell linesÖzgültekin Asu0İnan Asuman1Bozali Kubra2Özkan Beyza Nur3Güler Eray Metin4Department of Anesthesiology and Intensive Care, 448249Haydarpasa Numune Health Application and Research Center, University of Health Sciences Turkey, Istanbul, TürkiyeDepartment of Infectious Diseases, Haydarpasa Numune Health Application and Research Center, University of Health Sciences Turkey, Istanbul, TürkiyeDepartment of Medical Biochemistry, Faculty of Hamidiye Medicine, University of Health Sciences Turkey, Istanbul, TürkiyeDepartment of Medical Biochemistry, Faculty of Hamidiye Medicine, University of Health Sciences Turkey, Istanbul, TürkiyeDepartment of Medical Biochemistry, Faculty of Hamidiye Medicine, University of Health Sciences Turkey, Istanbul, TürkiyeThe widespread use of propofol, fentanyl, and midazolam in intensive care units necessitates a thorough understanding of their potential toxic effects. These sedative-hypnotic agents are frequently administered in combination to manage critically ill patients, raising concerns about their cumulative toxicity. To address this, we investigated the cytotoxic and genotoxic effects of these drugs, both individually and in combination, on a human liver epithelial cell line (THLE-2). The liver, as a major organ involved in drug metabolism, is particularly vulnerable to drug-induced toxicity. By evaluating the impact of these agents on liver cells, we aim to gain insights into their potential adverse effects and inform clinical practice.https://doi.org/10.1515/tjb-2024-0234cytotoxiciyhepatotoxicityfentanylpropofolmidazolam |
| spellingShingle | Özgültekin Asu İnan Asuman Bozali Kubra Özkan Beyza Nur Güler Eray Metin Investigation of propofol, fentanyl, and midazolam-related toxicity and the protective effect of midazolam on THLE-2 cell lines Türk Biyokimya Dergisi cytotoxiciy hepatotoxicity fentanyl propofol midazolam |
| title | Investigation of propofol, fentanyl, and midazolam-related toxicity and the protective effect of midazolam on THLE-2 cell lines |
| title_full | Investigation of propofol, fentanyl, and midazolam-related toxicity and the protective effect of midazolam on THLE-2 cell lines |
| title_fullStr | Investigation of propofol, fentanyl, and midazolam-related toxicity and the protective effect of midazolam on THLE-2 cell lines |
| title_full_unstemmed | Investigation of propofol, fentanyl, and midazolam-related toxicity and the protective effect of midazolam on THLE-2 cell lines |
| title_short | Investigation of propofol, fentanyl, and midazolam-related toxicity and the protective effect of midazolam on THLE-2 cell lines |
| title_sort | investigation of propofol fentanyl and midazolam related toxicity and the protective effect of midazolam on thle 2 cell lines |
| topic | cytotoxiciy hepatotoxicity fentanyl propofol midazolam |
| url | https://doi.org/10.1515/tjb-2024-0234 |
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