Lysine deacetylase inhibitors have low selectivity in cells and exhibit predominantly off‐target effects

Lysine deacetylase inhibitors have low selectivity in cells and exhibit predominantly off‐target effects

Lysine deacetylases (KDACs or HDACs) are metal‐dependent enzymes that regulate lysine acetylation, a post‐translational modification that is present on thousands of human proteins, essential for many cellular processes, and often misregulated in diseases. The selective inhibition of KDACs would allo...

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Bibliographic Details
Main Authors: Kiara E. Bornes, Marcus A. Moody, Thomas M. Huckaba, Megan C. Benz, Emily C. McConnell, Maryam Foroozesh, Van H. Barnes, Bridgette M. Collins‐Burow, Matthew E. Burow, Terry J. Watt, Tasha B. Toro
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:FEBS Open Bio
Subjects:
HDAC6
HDAC8
HDACi
immunofluorescence
RNA‐seq
Online Access:https://doi.org/10.1002/2211-5463.13896
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