Assessment of pharmacokinetics-pharmacodynamics relationship of tropoxine in rats
ResuLts of precLinicaL pharmacodynamic and pharmacokinetic study of tropoxine (a new originaL antimigraine drug) after singLe intravenous administration in rats were presented. Tropoxine in significant extent suppresses constricting reactions of rat brain vesseLs, serotonin, and agonist of 5НТ2В/2С...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2016-09-01
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| Series: | Фармакокинетика и Фармакодинамика |
| Subjects: | |
| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/179 |
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| author | V. P. Zherdev G. B. Kolyvanov A. A. Litvin A. A. Novitskyi T. S. Ganshina A. A. Gorbunov R. S. Mirzoyan |
| author_facet | V. P. Zherdev G. B. Kolyvanov A. A. Litvin A. A. Novitskyi T. S. Ganshina A. A. Gorbunov R. S. Mirzoyan |
| author_sort | V. P. Zherdev |
| collection | DOAJ |
| description | ResuLts of precLinicaL pharmacodynamic and pharmacokinetic study of tropoxine (a new originaL antimigraine drug) after singLe intravenous administration in rats were presented. Tropoxine in significant extent suppresses constricting reactions of rat brain vesseLs, serotonin, and agonist of 5НТ2В/2С receptors. Direct reLationship between tropoxine concentrations decreasing in the rat bLood pLasma and changing of the brain circuLation associated with serotonin and m-chLorphenyLpiperazine. |
| format | Article |
| id | doaj-art-2b07eafbe807446cb773e98bf0896513 |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2016-09-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-2b07eafbe807446cb773e98bf08965132025-08-20T03:42:31ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302016-09-01032125178Assessment of pharmacokinetics-pharmacodynamics relationship of tropoxine in ratsV. P. Zherdev0G. B. Kolyvanov1A. A. Litvin2A. A. Novitskyi3T. S. Ganshina4A. A. Gorbunov5R. S. Mirzoyan6FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»ResuLts of precLinicaL pharmacodynamic and pharmacokinetic study of tropoxine (a new originaL antimigraine drug) after singLe intravenous administration in rats were presented. Tropoxine in significant extent suppresses constricting reactions of rat brain vesseLs, serotonin, and agonist of 5НТ2В/2С receptors. Direct reLationship between tropoxine concentrations decreasing in the rat bLood pLasma and changing of the brain circuLation associated with serotonin and m-chLorphenyLpiperazine.https://www.pharmacokinetica.ru/jour/article/view/179тропоксинвысокоэффективная жидкостная хроматография-масс-спектрометрияфармакокинетика-фармакодинамикамигреньtropoxinehplc-mspharmacokinetics-pharmacodynamicsmigraine |
| spellingShingle | V. P. Zherdev G. B. Kolyvanov A. A. Litvin A. A. Novitskyi T. S. Ganshina A. A. Gorbunov R. S. Mirzoyan Assessment of pharmacokinetics-pharmacodynamics relationship of tropoxine in rats Фармакокинетика и Фармакодинамика тропоксин высокоэффективная жидкостная хроматография-масс-спектрометрия фармакокинетика-фармакодинамика мигрень tropoxine hplc-ms pharmacokinetics-pharmacodynamics migraine |
| title | Assessment of pharmacokinetics-pharmacodynamics relationship of tropoxine in rats |
| title_full | Assessment of pharmacokinetics-pharmacodynamics relationship of tropoxine in rats |
| title_fullStr | Assessment of pharmacokinetics-pharmacodynamics relationship of tropoxine in rats |
| title_full_unstemmed | Assessment of pharmacokinetics-pharmacodynamics relationship of tropoxine in rats |
| title_short | Assessment of pharmacokinetics-pharmacodynamics relationship of tropoxine in rats |
| title_sort | assessment of pharmacokinetics pharmacodynamics relationship of tropoxine in rats |
| topic | тропоксин высокоэффективная жидкостная хроматография-масс-спектрометрия фармакокинетика-фармакодинамика мигрень tropoxine hplc-ms pharmacokinetics-pharmacodynamics migraine |
| url | https://www.pharmacokinetica.ru/jour/article/view/179 |
| work_keys_str_mv | AT vpzherdev assessmentofpharmacokineticspharmacodynamicsrelationshipoftropoxineinrats AT gbkolyvanov assessmentofpharmacokineticspharmacodynamicsrelationshipoftropoxineinrats AT aalitvin assessmentofpharmacokineticspharmacodynamicsrelationshipoftropoxineinrats AT aanovitskyi assessmentofpharmacokineticspharmacodynamicsrelationshipoftropoxineinrats AT tsganshina assessmentofpharmacokineticspharmacodynamicsrelationshipoftropoxineinrats AT aagorbunov assessmentofpharmacokineticspharmacodynamicsrelationshipoftropoxineinrats AT rsmirzoyan assessmentofpharmacokineticspharmacodynamicsrelationshipoftropoxineinrats |